ljimbo423
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LINKPutting the patient back together
Unutmaz hypothesizes that ME/CFS is caused by a change in a patient’s microbiome after an infection. Our microbiome consists of our microbes—trillions of bacteria, viruses, and fungi that are living in and on our bodies.
A misbalance in our microbes can change the makeup of our entire microbiome, which triggers an inflammatory response and causes the immune system to perceive that there is still a danger in our bodies – even when an infection is long gone.
Here is a study that has the same basic hypothesis-
One current model of disease suggests that a trigger event (e.g. infection) results in a chronic inflammatory state characterized by increased proinflammatory cytokine production, increased reactive oxygen and nitrogen species, altered intracellular signaling,
increased intestinal permeability and systemic activation of innate immune receptors, altered glutaminergic and dopaminergic neurotransmission, mitochondrial dysfunction, and aberrant autoimmune responses
LINKWe hypothesized that the ecology of the gut microbiota of ME/CFS patients would differ from that of matched healthy controls and that these differences would be associated with increased bacterial translocation from the gut to the circulatory system following exercise challenge with corresponding worsening of symptoms (i.e, pain, fatigue, and mood).
The results presented here add further to the previous findings suggesting that ME/CFS patients have an altered gut microbiome and further suggest that increased bacterial translocation following exercise provides a potential explanation for the profound post-exertional malaise experienced by some ME/CFS patients.
This is what another leading ME/CFS researcher, Chris Armstrong says about an altered microbiome and increased intestinal permeability (Leaky gut) causing PEM-
LINKWell we all experience a bacteremia when we exercise. The type of bacteria that enter your bloodstream are usually quite controllable by your immune system but if your gut is further compromised they may release more
bacteria into your blood or more pathogenic species or your immune system may already be depleted. This is the concept for the chronic sepsis or SIRS and this is what I think may be behind PEM.
That's 2 leading ME/CFS researchers that have the same hypothesis, so far! It's no surprise to me, that all of the 5 ME/CFS collaborative research teams are focused on the gut, immune system, metabolomics and the brain.
There are also 5 more teams working for the Solve ME/CFS initiative (SMCI). They are also mainly focused on the gut, immune system and metabolomics-
I think many of these researchers have a pretty good idea of what the root cause of ME/CFS is.We will update our community on these projects as they kick off in January 2018. Importantly, these studies will advance the knowledge for diagnosis and characterization of ME/CFS in at least five key areas where we still have considerable knowledge gaps:
- Biomarkers for initiation (infection) and metabolic derangement in ME/CFS (Team 1, Sweden)
- Epigenetic regulation in specific immune cell types (Team 2, USA and Spain)
- Intestinal virome alterations and abnormalities in ME/CFS (Team 3, United Kingdom)
- Immunometabolism of T cells and monocytes in ME/CFS (Team 4, Germany)
- Antibody reactivities against autoantigens & the microbiome in ME/CFS (Team 5, Israel)
That's why they are researching these specific areas. Their challenge is finding the biological bio-markers to connect the gut, immune system, metobolomics and the brain.
I have no doubt they will do it!
Jim
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