- Messages
- 14
CC : @Janet Dafoe (Rose49) , @Hip , @Learner1 , @FMMM1 ,@Frenchguy, @JaimeS
Dear All,
As i now have a confirmation from Professor Murovska (Chair of EUROMENE Network), i will be presenting my 5-year Research on ME/CFS and several other syndromes such as Post-Finasteride Syndrome, Post-Accutane Syndrome, Post-treatment Lyme disease Syndrome and Gulf War Ilness Syndrome on September 13th in London on researchers of the EUROMENE Network,
As many of you know, these techniques were able to identify earlier from other Research efforts the importance of Phospholipids, Bile Acid Metabolism and Pyruvate Dehydrogenase.
These methods have also shown that Liver function / Disease may be very closely related to ME/CFS.
Here are the latest algorithmic findings :
-Confirmation of the potential importance of Gut and Gut Microbiome.
-Importance of Butyric Acid and Butyrate. Butyrate has been discussed on a post by @adreno here in PR however the use of Butyric Acid instead of Butyrate should be further investigated. I provide below a number of interesting excerpts regarding Butyric Acid :
Of interest is the fact that Butyric acid works through MFGE8. Regarding MFGE8 (which has been also found to be important algorithmically) and its association with Gut Lining, Sepsis , Anti-inflammatory action please see the following post :
https://forums.phoenixrising.me/ind...ated-to-sepsis-inflammation-gut-lining.59155/
My goal in the presentation will be to convince researchers to pay particular attention to Liver pathology and to several conditions (such as Hemochromatosis), that affect Liver function (and as a result Bile acid Metabolism, Oxidative Stress Management, Detoxification and many more).
According to the hypothesis discussed, an imperative step is the careful examination and assessment of enterohepatic functioning of ME/CFS patients.
I will post more information regarding Butyric acid, Liver Disease, Gut Dysbiosis and Lining very soon.
Dear All,
As i now have a confirmation from Professor Murovska (Chair of EUROMENE Network), i will be presenting my 5-year Research on ME/CFS and several other syndromes such as Post-Finasteride Syndrome, Post-Accutane Syndrome, Post-treatment Lyme disease Syndrome and Gulf War Ilness Syndrome on September 13th in London on researchers of the EUROMENE Network,
As many of you know, these techniques were able to identify earlier from other Research efforts the importance of Phospholipids, Bile Acid Metabolism and Pyruvate Dehydrogenase.
These methods have also shown that Liver function / Disease may be very closely related to ME/CFS.
Here are the latest algorithmic findings :
-Confirmation of the potential importance of Gut and Gut Microbiome.
-Importance of Butyric Acid and Butyrate. Butyrate has been discussed on a post by @adreno here in PR however the use of Butyric Acid instead of Butyrate should be further investigated. I provide below a number of interesting excerpts regarding Butyric Acid :
Butyric acid, a short-chain fatty acid and one of the main metabolites of intestinal microbial fermentation of dietary fiber, has been shown to have an important role in maintaining the integrity of the intestinal mucosa, while it also has been shown to exert potent anti-inflammatory effects both in vitro and in vivo.
We exposed colonic epithelial cells to butyric acid, then extracted total RNA samples, and subsequently hybridized them to microarray chips. Among the upregulated genes, milk fat globule-epidermal growth factor 8 (MFG-E8) was elevated by approximately fivefold. We previously reported that the potential therapeutic benefits of MFG-E8 in intestinal tissue injury were dependent not only on enhanced clearance of apoptotic cells but also required diverse cellular events for maintaining epithelial integrity. The influence of butyric acid on cell function is often attributed to its inhibition of histone deacetylases (HDACs). We found that acetylation on histone 3 lysine 9 (acetyl-H3K9) around the MFG-E8 promoter was significantly increased with butyric acid exposure
Of interest is the fact that Butyric acid works through MFGE8. Regarding MFGE8 (which has been also found to be important algorithmically) and its association with Gut Lining, Sepsis , Anti-inflammatory action please see the following post :
https://forums.phoenixrising.me/ind...ated-to-sepsis-inflammation-gut-lining.59155/
My goal in the presentation will be to convince researchers to pay particular attention to Liver pathology and to several conditions (such as Hemochromatosis), that affect Liver function (and as a result Bile acid Metabolism, Oxidative Stress Management, Detoxification and many more).
According to the hypothesis discussed, an imperative step is the careful examination and assessment of enterohepatic functioning of ME/CFS patients.
I will post more information regarding Butyric acid, Liver Disease, Gut Dysbiosis and Lining very soon.