Maureen Hanson's presentation at Solve CFS

Sean

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Now available on Youtube
Appreciate the video link, it is certainly a good talk.

But the sound quality makes for hard listening. Is there a better source for the audio?

I have checked the labroots site, but can't find the original video to see if the sound is any better.
 

Forbin

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Interesting video!

I wonder if it would be worthwhile to compare the histories of antibiotic use between the two twins with differing microbiome diversity. Not that I think antibiotic use is the trigger of ME/CFS, but I do wonder if the changes that antibiotics may make to the microbiome might set you up to be vulnerable to some kind of trigger.
 

AndyPR

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Appreciate the video link, it is certainly a good talk.

But the sound quality makes for hard listening. Is there a better source for the audio?

I have checked the labroots site, but can't find the original video to see if the sound is any better.
I'm unaware of any other audio or video source. I am working on a transcript of it though at the moment (just for the hell of it really, I have no link to Solve CFS at all) so hope to have that available today.
 

sarah darwins

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I found Dr Hanson's full PDF about her latest findings. Here is the link and its free. Cannot say I understand the technical stuff cos I don't but I am sure there are others here who do.

https://www.researchgate.net/public...gic_encephalomyelitischronic_fatigue_syndrome

Pam
Nice one, Pam. While on Research Gate I got steered to another microbiome article which is fascinating stuff. It's an interview with Paul Wischmeyer about the depletion of gut flora in critically ill patients in ICUs. Couple of extracts that caught my eye:

One of the bacteria we noted was quite depleted in the sick patients is a Faecalibacterium, which is a very important bacterium that makes short-chain fatty acids and helps nourish and protect the gut under normal and stress circumstances. It’s been shown to be deficient in inflammatory bowel disease, and probably plays a role in controlling inflammation in the gut. Significant depletion of this bacterium had not to our knowledge been well-described before in critical illness, so that’s one of the first results. Faecalibacterium is likely a bacterial species we should be studying as a replacement for our patients, because it probably plays a key role physiologically, and it becomes quite depleted in acute illness.
and especially the closing paragraph:

We can save just about anybody in the ICU from just about anything and get them out of the hospital. But the reality is these patients are so depleted, they’re never able to go back to their lives as normal. Many of them, because of their weakened state and the other things we’ve done to their bodies and microbiomes, will die within a year, never having held their grandkids again, never having walked down the street with their spouse again. With all of our advances in critical care, we must ask ourselves, are we creating survivors or are we creating victims, people who will never really go home and back to the quality of life they had before? Now that we’ve gotten good enough to save people from severe disease and injury, we need to work on ways of restoring health and life and normalcy. By creating effective methods of restoring the microbiome, together with nutrition and exercise, we hope we can begin to give people their lives back.
- my bolding

Link to the full interview transcript: https://www.researchgate.net/blog/post/critical-but-overlooked-icu-patients-gut-bacteria
 

Hilary

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Great talk by Maureen Hanson and huge thanks to her for drawing attention to the lack of funding and especially the ludicrous and misleading photographs used in the press.
I wonder if Prof McIntosh would be interested in watching and noting the overlap with Naviaux's study?..

H
 

JamBob

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rs3928306 - A
i3001578 (rs2853511) - T
rs2853513 - T
i3001901 (rs62581312) - T
rs3928305 - A

Thanks for looking these up @Valentijn - I have T for i3001578 (Accomplished less physical & Physical limitations ) and T for rs2853513 (Sensitivity to bright lights & Neuro inflammatory distress) - these definitely fit with some of my symptoms.

I'm just wondering though - do these results only apply if you are in one of the mtDNA haplogroups that they tested. My mtDNA haplogroup is very strange (C - it's supposed to be native American but I am a very Celtic-looking Brit) and not one of the tested groups - in the paper it says that they only tested European mtDNA groups.

Also out of interest - how do you do your conversion from the position given to the SNP code - is there some kind of website you use? I often find I don't know which SNP a study is working with as I don't know how to convert from one code to the codes used by 23&Me.
 

Valentijn

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I'm just wondering though - do these results only apply if you are in one of the mtDNA haplogroups that they tested.
If a SNP is having an impact on a gene, that impact will be present regardless of ethnicity. If results in research are showing an impact in some groups but not others, there's either a bigger factor at play (diet, a different SNP, etc), or the results are a meaningless fluke. Quality is often poor in SNP association studies, so any disparity is usually down to a fluke.
Also out of interest - how do you do your conversion from the position given to the SNP code - is there some kind of website you use?
I have 23andMe results in an excel spreadsheet with chromosome (or MTDNA) positions, so that makes it easier to find. If 23andMe is using an "i" number instead of an "rs" ID, I look up a nearby rsID on http://www.ncbi.nlm.nih.gov/projects/SNP/ and scroll left or right on the map view to find the SNP at the position that I'm looking for.