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Mark Davis Article: Identification of a Protective Role of T-Cells in Autoimmune Disease

Gemini

Senior Member
Messages
1,176
Location
East Coast USA
Mark Davis, renowned Stanford Immunologist, has identified a protective role for suppressive CD8+ T-Cells in autoimmune diseases which could lead to new types of treatments.

His findings were published in Nature, August 22, 2019 and are based on a comprehensive study of T-cells, both CD4+ and CD8+, dynamics.

Tony Fauci, NIAID Director, showcased these findings at his Sept. 9, 2019 Advisory Council Meeting:

MM Davis Autoimmune Disease article Aug 2019.PNG


Excerpt from the article:

In summary, the work presented here indicates there is a subset of CD8+ T-cells that can suppress pathogenic CD4+ T-cells in mice and probably in humans...Determining the ligands for these regulatory CD8+T-cells in autoimmune diseases could be of therapeutic importance.

Very technical article, perhaps @Simon can have a look?

Mark Davis is studying T-cell clonal expansion in ME/CFS, any connection?

https://www.ncbi.nlm.nih.gov/pubmed/31391585
 
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