mao a r297r geneticgenie shows ++ livewello -- who's right?

[matters]

Hi Guys,

Hope everybody is doing well.

I'm digging into methylation since I think it's a huge component. I've used a few different services based on my raw data from 23andme.com and found a glaring inconsistency.

As the title states, I'm showing homozygous for MAO A RT97R T on genetic genie.. which i don't really understand since there is only 1 allele. But anyway, Livewello has me showing normal - - and there's two alleles by the way TT

Who's right you think? I know which outcome I'm rooting for, but need somebody's help

Anybody else show this discrepancy?

I opened up the raw data file and I think I found the snippet
rs6323 X 43591036 T

Hopefully it will shed some light on which interpretation is accurate


Thanks so much for your help

 

[Valentijn]

@matters - You're a guy, and MAOA is on the X chromosome, so you only have one allele. So you're not homozygous or heterozygous. Rather the technical term is "hemizygous"

I wouldn't worry about MAOA in general, unless you have symptoms involving psychiatric neurotransmitters. Otherwise the only "risk" is an exaggerated over-attribution of a personality type. Otherwise one version might indicate problems with supplementing methylB12.

 

[tckats]

I got the same results. I have a child with OCD behaviors showing so I would be interested in knowing which is correct. I did see that Genetic Genie reports the "wild" mutation. I have no clue what this means but they say that the "wild" one is designated with a -/-. I am thinking this means we do NOT have the mutation with a +/+. I would love some kind of confirmation from a more knowledgeable person though. Any information would be greatly appreciated.

 

[Valentijn]

I got the same results. I have a child with OCD behaviors showing so I would be interested in knowing which is correct. I did see that Genetic Genie reports the "wild" mutation. I have no clue what this means but they say that the "wild" one is designated with a -/-. I am thinking this means we do NOT have the mutation with a +/+. I would love some kind of confirmation from a more knowledgeable person though. Any information would be greatly appreciated.

"Wild type" is simply the more common version.