Doing metabolomics testing to understand one's individual biochemistry is essential. Having an understanding of one's genes, environmental exposures, etc. is critical, too. Then, a clever doctor can personalize a plan that meets the individual's needs.
We are all unique individuals with unique genes and environmental factors. It is pretty impossible for scientists to come up with sports of identical patients to run experiments are. We are not identical widgets.
Yes, I have hemachromatosis, and it has been treated. I had some other things, like chlamydia pneumoniae and heavy metal toxicity stressing my liver.
You make a good point that genetic conditions should be identified in individuals. I also have a lot of other interesting genes that may be impacting my situation, as other patients do, too.
As for curcumin, I have benefited in multiple situations from it. It has different mechanisms of action, which I have found to be extremely effective, and which are based on sound science. It is a COX-2 inhibitor, is a broad spectrum Phase II detoxifier, and has cancer-fighting properties. I have seen it reverse cancers that have been resistant to multiple chemo regimens. In my case, it has helped with removing toxic arsenic metabolites stuck halfway through the detox process. It has also calmed down brain and intestinal inflammation caused by intravenous immunoglobulins.
I suspect your network needs a few more data points to take into account all of my issues before recommending whether treatments that will or won't work. Real life is more complex than most studies.