I don't know specifics but there is a tremendous amount of information on the internet regarding the role of the immune system and healing. I've copied a few abstracts below - none specific to CFS/ME. I've highlighted and italicized mention of immune system function in healing. Where is appears PWC have impaired immune function, it only makes sense bruising is more common. Vitamin K deficiency can also be a cause of easy bruising. Hope thi
Semin Cell Dev Biol. 2009 Jul;20(5):517-27. Epub 2009 Apr 22.
Interrelation of immunity and tissue repair or regeneration.
Eming SA, Hammerschmidt M, Krieg T, Roers A.
Department of Dermatology, University of Cologne, Germany. email@example.com
Although tremendous progress has been achieved in understanding the molecular basis of tissue repair and regeneration in diverse model organisms, the tendency of mammals for imperfect healing and scarring rather than regeneration remains unexplained. Moreover, conditions of impaired wound healing, e.g. non-healing skin ulcers associated with diabetes mellitus or vascular disease, as well as excessive scarring, represent major clinical and socio-economical problems. The development of innovative strategies to improve tissue repair and regeneration is therefore an important task that requires a more thorough understanding of the underlying molecular and cellular mechanisms.
There is substantial evidence in different model organisms that the immune system is of primary importance in determining the quality of the repair response, including the extent of scarring, and the restoration of organ structure and function.
Findings in diverse species support a correlation between the loss of regeneration capacity and maturation of immune competence. However, in recent years, there is increasing evidence on conditions where the immune response promotes repair and ensures local tissue protection. Hence, the relationship between repair and the immune response is complex and there is evidence for both negative and positive roles.
We present an overview on recent evidence that highlights the immune system to be key to efficient repair or its failure.
First, we summarize studies in different model systems that reveal both promoting and impeding roles of the immune system on the regeneration and repair capacity. This part is followed by a delineation of diverse inflammatory cell types, selected peptide growth factors and their receptors as well as signaling pathways controlling inflammation during tissue repair. Finally, we report on new mechanistic insights on how these inflammatory pathways impair healing under pathological conditions and discuss therapeutic implications.
PMID: 19393325 [PubMed - indexed for MEDLINE]
Surv Ophthalmol. 2000 Jul-Aug;45(1):49-68.
The role of the immune system in conjunctival wound healing after glaucoma surgery.
Chang L, Crowston JG, Cordeiro MF, Akbar AN, Khaw PT.
Wound Healing Research and Glaucoma Units, Institute of Ophthalmology, London, United Kingdom.
The immune system has a fundamental role in the development and regulation of ocular healing, which plays an important role in the pathogenesis of most blinding diseases. This review discusses the mechanisms of normal wound healing, describing the animal and fetal wound healing models used to provide further insight into normal wound repair. In particular, conjunctival wound repair after glaucoma filtration surgery will be used to illustrate the contributions that the different components of the immune system make to the healing process. The potential role of macrophages, the possible regulatory effect of lymphocytes, and the important role of growth factors and cytokines in the wound healing reaction are discussed.
The significance of the immune system in the pathogenesis of aggressive conjunctival scarring is addressed, particularly assessing the predisposing factors, including drugs, age, and ethnicity. The rationale behind the pharmacological agents currently used to modulate the wound healing response and the effects these drugs have on the function of the immune system are described. Finally, potential new therapeutic approaches to regulating the wound healing response are reported.
PMID: 10946081 [PubMed - indexed for MEDLINE]
Arch Dermatol Res. 2009 Apr;301(4):259-72. Epub 2009 Apr 10.
Keloid scarring: bench and bedside.
Seifert O, Mrowietz U.
Department of Dermatology, County Hospital Ryhov, Jonkoping 55185, Sweden. firstname.lastname@example.org
Wound healing is a fundamental complex-tissue reaction leading to skin reconstitution and thereby ensuring survival. While, fetal wounds heal without scarring, a normal "fine line" scar is the clinical outcome of an undisturbed wound healing in adults. Alterations in the orchestrated wound healing process result in hypertrophic or keloid scarring.
Research in the past decades attempted to identify genetic, cellular, and molecular factors responsible for these alterations. These attempts lead to several new developments in treatments for keloids, such as, imiquimod, inhibition of transforming growth factor beta, and recombinant interleukin-10. The urgent need for better therapeutics is underlined by recent data substantiating an impaired quality of life in keloid and hypertrophic scar patients. Despite the increasing knowledge about the molecular regulation of scar formation no unifying theory explaining keloid development has been put forward until today. This review aims to give an overview about the genetic and molecular background of keloids and focus of the current research on keloid scarring with special emphasis on new forthcoming treatments. Clinical aspects and the spectrum of scarring are summarized.
PMID: 19360429 [PubMed - indexed for MEDLINE]