bertiedog
Senior Member
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- 1,746
- Location
- South East England, UK
I wanted to post about my experiences with LDN changing my immune system and endocrine system and have come to the conclusion it is a great alternative way of modifying these and obviously far cheaper and safer than Ruituximab.
I am writing notes how exactly LDN works (have got a book on LDN on my Kindle) and it talks about how the immune system is constantly interacting with the neuro endocine system. It states "These bi-directional interactions influence antibody and cytokine responses, cytolytic activity, lymphocytes proliferation, tissue localisation of lymphocytes,hypothalamic-pituitary hormone secretion and neural signal transmission. Best illustrated in the body's response tostress.
Stress can either suppress or enhance immune responses. " (The promise of Low Dose Naltrexone Therapy by Elaine Moore et al)
As a bit of background on myself I am 66 years old and was given the diagnosis of ME/CFS in 2000 when I could no longer carry on teaching to my extreme ill health. One of the first things that were obvious was that my adrenals were whacked and my thyroid wasn't working well. I could never walk for longer than 20 minutes but this is slowly improving but still a way to go. I was given replacement steroids in 2002 by a private Endo because of my extreme symptoms and also dessicated thyroid. My doses settled around 6.5 mg Prednisolone (had been less 10 years ago) and 2 grains Nature-Thyroid plus 25 mcg thyroxine for the Hashimotos.
I started just 1 mg LDN on 17 June this year and within 4 weeks little signs were there that my thyroid was changing (sweating attacks and raised pulse). Unfortunately I missed these signs as it was very hot weather at the time. In July I started herbal treatment for Lyme disease, and in July started Cats Claw and Andrographis.
Over the past few weeks things have gone into overdrive in a quite unpleasant way. Terrible sweating attacks making me soaking wet, high bp and pulse. Eventually last week I felt so ill that after looking through my diary the penny dropped and I realised what had happened and I started drastically reducing my thyroid and adrenal meds. I still don't know what I need but it looks like it might just be the 0.25 mcg thyroxine if at all and I am still finding out what steroid dose I need. So far today its only been 1 mg Pred and 2.5 mg hydrocortisone, a big drop. I expect to need a tiny bit more of h/c later in the day to support my body.
It would seems that in my case there are several factors that have caused my HPA axis to be whacked. Firstly I was mercury poisoned, this started to happen from age 15 when I reacted badly to the TB jab which would have used thimerasol which is 50% mercury. Following on from that I had lots of amalgams done around the age of 18. Around this time I would get severe nose bleeds and migraines started too. The mercury issue would have continued to get worse as each amalgam was placed, I ended up with 14 amalgams and one gold crown that had amalgam underneath. These were all removed over 10 months in 2002/3 and I chelated using Andy Cutlers protocol but know that it took 5 years for my lymphocytes to stop overreacting to mercury.
In 1975 after my 3 rd pregnancy I lost 4 pints of blood and they only put 2 back which would have caused a big shock to the pituitary.
In 1996 I think I got bitten giving me Lyme disease and possibly Ehrlichia too. Following on from that I picked up Campylabactor poisoning and other nasty infections. It was during this time my adrenals took a real nose dive and the thyroid too so in my case it has all be autoimmune and the LDN has gone a long way to sorting this out with the probably help of Cats Claw.
So if one has sorted out any heavy metal issues, reduced other stressors in one's life to a manageable level then LDN can do the rest and counter any autoimmune issues.
I also find that I don't have to take the LDN every day and I have heard from others too they only need it every other day.
Pam
I am writing notes how exactly LDN works (have got a book on LDN on my Kindle) and it talks about how the immune system is constantly interacting with the neuro endocine system. It states "These bi-directional interactions influence antibody and cytokine responses, cytolytic activity, lymphocytes proliferation, tissue localisation of lymphocytes,hypothalamic-pituitary hormone secretion and neural signal transmission. Best illustrated in the body's response tostress.
Stress can either suppress or enhance immune responses. " (The promise of Low Dose Naltrexone Therapy by Elaine Moore et al)
As a bit of background on myself I am 66 years old and was given the diagnosis of ME/CFS in 2000 when I could no longer carry on teaching to my extreme ill health. One of the first things that were obvious was that my adrenals were whacked and my thyroid wasn't working well. I could never walk for longer than 20 minutes but this is slowly improving but still a way to go. I was given replacement steroids in 2002 by a private Endo because of my extreme symptoms and also dessicated thyroid. My doses settled around 6.5 mg Prednisolone (had been less 10 years ago) and 2 grains Nature-Thyroid plus 25 mcg thyroxine for the Hashimotos.
I started just 1 mg LDN on 17 June this year and within 4 weeks little signs were there that my thyroid was changing (sweating attacks and raised pulse). Unfortunately I missed these signs as it was very hot weather at the time. In July I started herbal treatment for Lyme disease, and in July started Cats Claw and Andrographis.
Over the past few weeks things have gone into overdrive in a quite unpleasant way. Terrible sweating attacks making me soaking wet, high bp and pulse. Eventually last week I felt so ill that after looking through my diary the penny dropped and I realised what had happened and I started drastically reducing my thyroid and adrenal meds. I still don't know what I need but it looks like it might just be the 0.25 mcg thyroxine if at all and I am still finding out what steroid dose I need. So far today its only been 1 mg Pred and 2.5 mg hydrocortisone, a big drop. I expect to need a tiny bit more of h/c later in the day to support my body.
It would seems that in my case there are several factors that have caused my HPA axis to be whacked. Firstly I was mercury poisoned, this started to happen from age 15 when I reacted badly to the TB jab which would have used thimerasol which is 50% mercury. Following on from that I had lots of amalgams done around the age of 18. Around this time I would get severe nose bleeds and migraines started too. The mercury issue would have continued to get worse as each amalgam was placed, I ended up with 14 amalgams and one gold crown that had amalgam underneath. These were all removed over 10 months in 2002/3 and I chelated using Andy Cutlers protocol but know that it took 5 years for my lymphocytes to stop overreacting to mercury.
In 1975 after my 3 rd pregnancy I lost 4 pints of blood and they only put 2 back which would have caused a big shock to the pituitary.
In 1996 I think I got bitten giving me Lyme disease and possibly Ehrlichia too. Following on from that I picked up Campylabactor poisoning and other nasty infections. It was during this time my adrenals took a real nose dive and the thyroid too so in my case it has all be autoimmune and the LDN has gone a long way to sorting this out with the probably help of Cats Claw.
So if one has sorted out any heavy metal issues, reduced other stressors in one's life to a manageable level then LDN can do the rest and counter any autoimmune issues.
I also find that I don't have to take the LDN every day and I have heard from others too they only need it every other day.
Pam
Many people are reporting an improvement in symptoms with LDN. I'm looking forward to trying it myself.
