Low blood Ca2+ (ion calcium) mimics Small Fiber Neuropathy and central hyperexcitability

pattismith

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Calcium ion inhibits Voltage gated sodium channels, so when it's low, VG sodium channels becomes hyperexcitable, with all the symptoms (both central and peripheral) that go with it (see table below);

"Hypocalcemia is low calcium levels in the blood serum.
The normal range is 2.1–2.6 mmol/L (8.8–10.7 mg/dl, 4.3–5.2 mEq/L) with levels less than 2.1 mmol/l defined as hypocalcemia. "

But ionized calcium does not reach more than 50% of total blood calcium

"Hypocalcemia is defined as an ionized calcium concentration below the lower limit of the normal range (generally below 4.0-4.8 mg/dL [1.0-1.2 mmol/L]). It is the ionized calcium level that is a critical factor in numerous intracellular and extracellular functions and is responsible for the symptoms of hypocalcemia. "

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pattismith

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Ionized calcium is increased during blood acidosis, hyperparathyroidism and decreased in blood alkalosis, hypoparathyroidism

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Hypoparathyroidism causes (low ionized calcium)

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