After more then 3 years into full blown ME CFS and OI/POTS. I have lost 25 percent of my head volume. Before my ME CFS and after MECFS I compared my photo and I can clearly see my head had shrinked to 75% from before. So have lost 25% of my head/brain. My head is small now. Do any body notice this symptom? What is the reason behind this? Also I have lost so much intelligence like thinking power, lost memory and also have severe brain fog 24x7.