Loss of igg antibodies anyone

[heapsreal]

Just wondering how many have had a test that showed igg positive to an infection such as I did to ebv and several years later was negative igg ebv antibodies?

At the other end of the scale, a few years back i decided to stop antivirals but wanted to check my immunity to varicella. It came back saying I had high immunity. Suprise! I got shingles badly enough to put me off work for 3 months. I repeated this all again after 12 months and stopped antivirals as u dont get shingles more than once drs say 🤔😡. My dr actually said maybe the good immunity with high igg titres and it was actually an active infection?

Im just bringing this up as im watching an unrelated to cfs utube with an immunologist/viralogist, who basically said and im assuming igg after the supposed infection is gone, but basically said antibodies mean no infection. That sounds alot like it relates to normal people, not most of us who arent normal 🤔👾 doesnt explain my shingles issues and just maybe when i have a crash its ebv??

Those initial cfs outbreaks in the mid 1980s saw many cfsers lose ebv antibodies after once tests showed they had these antibodies.

Latent or active infections, antibodies high or low, it aint black n white😧

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[Pyrrhus]

It happened to me, in a way. As a child, my mother and I used to get horrible cold sores on our lips. Cold sores are caused by HSV-1. I haven't had cold sores for years, and when I checked my immunity, it said that I don't have any IgG or other antibodies to HSV-1.

I have two theories that may explain my lack of antibodies to HSV-1. The first is that I haven't had any reactivations for so long, that my antibodies faded away. The second theory is that I contracted HSV-1 in utero, and was born with HSV-1. Since I was born with it, my adaptive immune system treated HSV-1 as "self" rather than as "foreign", and my adaptive immune system didn't produce any antibodies to HSV-1, treating the virus as a normal part of the body. (Fortunately, the innate immune system knows better, and has multiple anti-herpes strategies.)

At the other end of the scale, a few years back i decided to stop antivirals but wanted to check my immunity to varicella. It came back saying I had high immunity. Suprise! I got shingles badly enough to put me off work for 3 months. I repeated this all again after 12 months and stopped antivirals as u dont get shingles more than once drs say 🤔😡. My dr actually said maybe the good immunity with high igg titres and it was actually an active infection?

Your doctor was probably right. There is evidence that most reactivations of the varicella virus do not produce any visible shingles. You may have had an active reactivation of varicella before you broke out in shingles. (And yes, some people get shingles more than once.)

Hope this helps.