Bob
Senior Member
- Messages
- 16,455
- Location
- England (south coast)
This list was last refreshed on 1st August 2011.
I've aimed to make this a comprehensive list, hopefully including all of the high profile studies relating to XMRV/CFS, but there maybe studies that I've overlooked.
Any suggestions for additional info, corrections and improvements are very welcome.
Within each category, the papers are listed in order of the date of publication.
Contents:
XMRV in CFS Patients - Published positive studies
PMRV in CFS Patients - Published positive studies
XMRV in CFS Patients - unpublished positive studies abstracts & reports
XMRV in CFS Patients - future studies
Other published positive XMRV studies (Not CFS or Prostate cancer)
Other unpublished positive XMRV & PMRV studies (Not CFS or Prostate cancer)
XMRV/Human DNA integration papers
Conferences - and lists of abstracts
Investigative XMRV studies
XMRV & CFS Patients - Published negative studies
Inconclusive studies & studies that add some knowledge about XMRV
Overviews of XMRV research
Reviews
Letters to Scientific Journals
Blood Related Studies & Reviews
Patents applied for
Positive XMRV Prostate Cancer studies
Unpublished Positive XMRV Prostate Cancer studies
Inconclusive & No Association XMRV Prostate Cancer studies (Some XMRV detected)
Negative XMRV Prostate Cancer Studies (No XMRV detected)
Negative XMRV studies other
Contamination studies and theories
Papers that provide evidence against contamination theories
MLV Recombination Theory studies
Other negative studies (Not CFS or Prostate cancer)
Science Journal editorial Expression of Concern.
Historical research looking at MLV-related viruses associated with human disease
Antiretroviral Research
Related/Relevant HIV Research
Related/Relevant HTLV Research
Other research related to XMRV/CFS
XMRV Sequences in genbank
Other information
Comparison Tables XMRV research studies
Conference Abstracts (A small selection of abstracts)
Student Theses relating to XMRV
Other resources
XMRV in CFS Patients - Published positive studies
Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome
Vincent C. Lombardi, Francis W. Ruscetti, Jaydip Das Gupta, Max A. Pfost, Kathryn S. Hagen, Daniel L. Peterson, Sandra K. Ruscetti, Rachel K. Bagni, Cari Petrow-Sadowski, Bert Gold, Michael Dean, Robert H. Silverman, and Judy A. Mikovits
Published Online 8 October 2009
Published in Science 23 October 2009
Science
http://www.sciencemag.org/content/326/5952/585.abstract
Addendum:
http://www.landesbioscience.com/journals/virulence/MikovitisVIRU1-5.pdf
Supplementary material:
http://www.ncbi.nlm.nih.gov/pubmed/20842203
PMRV in CFS Patients - Published positive studies
Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors
Shyh-Ching Lo, Natalia Pripuzova, Bingjie Li, Anthony L. Komaroff, Guo-Chiuan Hung, Richard Wang, and Harvey J. Alter
Published online before print August 23, 2010
PNAS
http://www.pnas.org/content/early/2010/08/16/1006901107.full.pdf+html
Results: 86.5% in CFS patients. 6.8% in healthy volunteer blood donors.
XMRV in CFS Patients unpublished positive studies abstracts & reports
Anything other studies to add here?
Detection of infectious XMRV in the peripheral blood of children
M A Pfost et al.
(WPI)
Looking for XMRV in families and testing: adults with ME, FM, Lymme disease; Parents of children with neuroimmune disease; children with ASD; children with Niemann-Pick; and healthy children with sibling who have neuroimmune disease. Positive results obtained.
http://regist2.virology-education.com/abstractbook/2010_8.pdf
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
Detection of infectious XMRV in the peripheral blood of chronic fatigue syndrome patients in the United Kingdom.
Mikovits et al.
(WPI)
Initial results reported to be about 80% positive for XMRV in UK ME patients, and 6-8% positive in the UK blood supply.
http://regist2.virology-education.com/abstractbook/2010_8.pdf
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
XMRV detection in a national practice specializing in CFS
P Cheney
Using the VIPdx lab, 74.5% of consecutive ME patients, who went to the Cheney Clinic, tested positive for XMRV.
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
Detection of MLV-like gag sequences in blood samples from a New York state CFS cohort
Maureen R Hanson, Li L Lee, Lin Lin, David E Bell, David Ruppert and David S Bell
Initial reported results = 80% of 10 patients currently meeting Fukuda criteria tested positive for MLV-related sequences, and 1% of healthy controls. (Reportedly finding PMRV rather than XMRV.)
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
http://www.cfids.org/xmrv/wrkshp-report.pdf
http://www.biomedcentral.com/content/files/pdf/1742-4690-8-S1-full.pdf
http://www.retrovirology.com/content/8/S1/A234
An extract from:
Of Mice and Men: A Summary of the First International XMRV Workshop.
by K. Kimberly McCleary with Steven H. Kleinman, BSc, MD, and Suzanne D. Vernon, PhD.
Dr. Hansons study tested samples obtained by David S. Bell from 20 CFS patients, 10 of whom reported having recovered but still demonstrated lower physical activity levels than the 10 healthy control subjects as measured by seven instruments employed by Dr. Bell. Of these 20 CFS patients, 11 (55%) were positive; 8 (80%) of the 10 patients currently meeting Fukuda criteria and 3 (30%) of the individuals who had recovered tested positive, compared to 1 (10%) of the 10 healthy controls. The gag sequences found by Dr. Hanson were more similar to those reported by Lo et al., than to the gag sequences for XMRV, although all are part of the same gammaretrovirus family. Her group is working to sequence the env sequence and the entire virus genome(s) now that they have external funding support from NIH.
http://www.cfids.org/xmrv/wrkshp-report.pdf
Kenny De Meirlier
Blinded study, using the VIPdx to test for XMRV
Initial reported results = XMRV detected in 57% of 84 CFS patients, and in 14% of 50 healthy donors.
http://www.investinme.org/IiME Conf...onal ME Conference 2011 Conference Report.htm
Wilfried Bieger (Germany)
Reported positive study, to be published sometime in 2011.
Detecting XMRV in 20% to 40% of 110 CFS patient samples.
http://www.investinme.org/IiME Conf...onal ME Conference 2011 Conference Report.htm
http://www.facebook.com/notes/xmrv-...-40-of-a-cohort-of-110-peop/10150253684766797
XMRV in CFS Patients - Future studies
The Norwegian study of CFS, NO-CFS, Stage 1: Confirmatory study for the detection on Gamma-retrovirus related Gene Sequences.
http://esme-eu.com/news/the-norwegi...irus-related-gene-sequences-article487-7.html
http://lhkpasientfora.org/wp-conten...krivelse_eng_NO_CFS_stage-one_XMRV-study1.pdf
Blood Working Group
link to info needed
Ian Lipkin
link to info needed
Dr. Frank Maldarelli
NIH - National Cancer Institute
The study will take blood samples from 60 people, divided equally between people who previously tested XMRV-positive and healthy individuals.
The data will be used to help formulate a gold standard for determining positive and negative results.
http://www.phillyburbs.com/blogs/wo...b-7981-56f2-b829-af35a545728e.html?mode=print
Other published positive XMRV studies (Not CFS or Prostate cancer)
Xenotropic Murine Leukemia Virusrelated Gammaretrovirus in Respiratory Tract
Nicole Fischer, Claudia Schulz, Kristin Stieler, Oliver Hohn, Christoph Lange, Christian Drosten, and Martin Aepfelbacher
June 2010
Emerg Infect Dis. 2010 Jun; DOI: 10.3201/eid1606.100066
http://www.cdc.gov/eid/content/16/6/1000.htm
(We detected XMRV in respiratory secretions of immunocompetent patients with and without RTI at a frequency of ?3.2%, which is in good concordance with the recently reported prevalence in the general population of up to 4%)
The Prevalence of XMRV in Healthy Blood Donors in Japan
XMRV reportedly found in 1.7% of random healthy blood donor samples from the blood supply in Japan, testing for antibodies only. (This was a study of blood bank samples and prostate cancer patients, not ME patients.)
"Although our study had a limited sample size, the prevalence among blood donors as determined by identifying XMRV-specific antibodies was found to be 1.7%, while that among prostate cancer patients was found to be 6.3%"
(Publication status unknown to me)
http://www.diagnosesupport.com/heal...ted-virus-in&catid=132:xmrv-research&Itemid=8
Other unpublished positive XMRV & PMRV studies (Not CFS or Prostate cancer)
Detection of infectious XMRV in the peripheral blood of children
M A Pfost et al. (WPI)
Looking for XMRV in families and testing: adults with ME, FM, Lymme disease; Parents of children with neuroimmune disease; children with ASD; children with Niemann-Pick; and healthy children with sibling who have neuroimmune disease. Positive results obtained.
http://regist2.virology-education.com/abstractbook/2010_8.pdf
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
Compositions And Methods Relating To Xmrv-Related Diseases And Conditions
Singh, Ila Ramnaresh; (US). Thaker, Harshwardhan Manohar; (US). Schlaberg, Robert; (US). Shin, Clifford; (US)
The University Of Utah Research Foundation
(XMRV in breast cancer)
Patent:
http://www.wipo.int/patentscope/search/en/WO2010132886
Info:
http://www.facebook.com/notes/xmrv-...s-on-xmrv-breast-cancer-prostate/472237776796
XMRV proviral DNA sequences or XMRV proteins were detected in approximately 25% of 178 breast cancer samples.
XMRV/Human DNA integration papers
Integration Site Preference of Xenotropic Murine Leukemia Virus-Related Virus, a New Human Retrovirus Associated with Prostate Cancer
Sanggu Kim, Namshin Kim, Beihua Dong, David Boren, Serena A. Lee, Jaydip Das Gupta, Christina Gaughan, Eric A. Klein, Christopher Lee, Robert H. Silverman, and Samson A. Chow
3 August 2008
Journal Of Virology, Oct. 2008
http://jvi.asm.org/cgi/reprint/82/20/9964
Multiple Integrated Copies and High-Level Production of the Human Retrovirus XMRV (Xenotropic Murine Leukemia Virus-Related Virus) from 22Rv1 Prostate Carcinoma Cells
Emily C. Knouf, Michael J. Metzger, Patrick S. Mitchell, Jason D. Arroyo, John R. Chevillet,
Muneesh Tewari, and A. Dusty Miller*
23 April 2009
Journal Of Virology, July 2009,
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704771/pdf/0546-09.pdf
Fidelity of target site duplication and sequence preference during integration of xenotropic murine leukemia virus-related virus.
Kim S, Rusmevichientong A, Dong B, Remenyi R, Silverman RH, Chow SA
April 20, 2010
PloS ONE
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010255
Deciphering the Code for Retroviral Integration Target Site Selection
Federico Andrea Santoni, Oliver Hartley, Jeremy Luban
November 24, 2010
PLoS Computational Biology
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991247/pdf/pcbi.1001008.pdf
Analysis of XMRV integration sites from human prostate cancer tissues suggests PCR contamination rather than genuine human infection.
Garson JA, Kellam P, Towers GJ.
25 February 2011
Retrovirology
http://www.retrovirology.com/content/8/1/13
Conferences - and lists of abstracts
CROI 2010 - 17th Conference on Retroviruses and Opportunistic Infections
February 16-19, 2010
XMRV related abstracts:
http://www.cfids.org/xmrv/croi-2010.asp
Program:
http://zika.retroconference.org/croi-2010-pocket-program.pdf
12th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI)
NCI. NIH. Office of HIV and AIDS Malignancy.
26-27 April 2010
http://www.capconcorp.com/meeting/12thICMAOI/agenda.asp
http://oham.cancer.gov/objects/pdf/2010ICMAOI_Program_Book.pdf
1st International Workshop on XMRV
The abstracts of the 1st International Workshop on XMRV are published in Reviews in Antiviral Therapy & Infectious Diseases 2010_8
7-8th September 2010
http://www.virology-education.com/i...erial/vid/1A5D65BD-FB8B-8AE1-5E10829372D080B4
Official Abstract Book:
http://regist2.virology-education.com/abstractbook/2010_8.pdf
List of Abstracts:
http://www.mecfsforums.com/wiki/Abstracts_from_1st_International_Workshop_on_XMRV
Oral and Poster presentations Table of results:
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
CROI 2011 - 18th Conference on Retroviruses and Opportunistic Infections
Feb 27 - 2nd March 2011
http://www.cfids.org/xmrv/croi-2011.asp
http://www.retroconference.org/2011/data/files/ProgramAtAGlance_11.pdf
American Urological Association meeting
April 2011
The Journal of Urology
http://www.jurology.com/article/S0022-5347(11)01618-1/fulltext
http://www.jurology.com/article/S0022-5347(11)01208-0/fulltext
http://www.jurology.com/article/S0022-5347(11)00620-3/fulltext
NIH State Of Knowledge (SOK) Workshop - Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Research
April 7-8, 2011
Website:
http://orwh.od.nih.gov/CSF 2011/newsEvents.htm
Agenda:
http://orwh.od.nih.gov/SOK AGENDA - Final.pdf
Video - Day 1
http://videocast.nih.gov/launch.asp?16575
Video - Day 2:
http://videocast.nih.gov/launch.asp?16571
American Urological Association meeting
April 2011
The Journal of Urology
http://www.jurology.com/article/S0022-5347(11)01618-1/fulltext
http://www.jurology.com/article/S0022-5347(11)01208-0/fulltext
http://www.jurology.com/article/S0022-5347(11)00620-3/fulltext
Invest in ME Conference 2011 (No abstracts presented)
The 6th Invest in ME International ME/CFS Conference 2011
20th May 2011
Conference Report by Rosamund Vallings of the Associated New Zealand ME Society:
http://www.investinme.org/IiME Conf...onal ME Conference 2011 Conference Report.htm
15th International Conference on Human Retrovirology: HTLV and Related Retroviruses
Saturday, June 4, 2011 to Wednesday, June 8, 2011
http://forums.phoenixrising.me/show...ce+on+Human+Retrovirology+-+List+of+Abstracts
http://www.research1st.com/2011/06/08/15th-htlvconf/
Investigative XMRV studies (Just a selection) (Please see conference abstracts for ongoing studies)
An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors
Beihua Dong, Sanggu Kim, Seunghee Hong, Jaydip Das Gupta, Krishnamurthy Malathi, Eric A. Klein, Don Ganem, Joseph L. DeRisi, Samson A. Chow, and Robert H. Silverman
November 27, 2006
PNAS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1776164/pdf/zpq1655.pdf
Quantification of reverse transcriptase in ALS and elimination of a novel retroviral candidate
A. L. McCormick, PhD, R. H. Brown Jr, MD, DPhil, M. E. Cudkowicz, MD, MSc, A. Al-Chalabi, PhD, FRCP and J. A. Garson, MD, PhD
July 18, 2007.
Neurology January 22, 2008
http://www.neurology.org/content/70/4/278.short
Molecular evolution of the prostate cancer susceptibility locus RNASEL: Evidence for positive selection
Kyle Summers, and Bernard Crespi
May 2008
Infection, Genetics and Evolution
http://www.sciencedirect.com/science/article/pii/S1567134808000075
A Natural Human Retrovirus Efficiently Complements Vectors Based on Murine Leukemia Virus
Beihua Dong, Robert H. Silverman, Eugene S. Kandel
September 4, 2008
PLoS ONE
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519784/pdf/pone.0003144.pdf
Fibrils of Prostatic Acid Phosphatase Fragments Boost Infections with XMRV (Xenotropic Murine Leukemia Virus-Related Virus), a Human Retrovirus Associated with Prostate Cancer
Seunghee Hong, Eric A. Klein, Jaydip Das Gupta, Kirsten Hanke, Christopher J. Weight, Carvell Nguyen, Christina Gaughan, Kyeong-Ae Kim, Norbert Bannert, Frank Kirchhoff, Jan Munch, and Robert H. Silverman
21 April 2009
JOURNAL OF VIROLOGY, July 2009
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704761/pdf/0268-09.pdf
Kyeong-Ae Kim, Norbert Bannert, Frank Kirchhoff, Jan Munch, and Robert H. Silverman
21 April 2009
JOURNAL OF VIROLOGY, July 2009
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704761/pdf/0268-09.pdf
Six host range variants of the xenotropic/polytropic gammaretroviruses define determinants for entry in the XPR1 cell surface receptor
Yuhe Yan, Qingping Liu and Christine A Kozak
7 October 2009
Retrovirology
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768677/pdf/1742-4690-6-87.pdf
Androgen Stimulates Transcription and Replication of XMRV (Xenotropic Murine Leukemia Virus-Related Virus)
Beihua Dong and Robert H. Silverman
11 November 2009
Journal of Virology
http://jvi.asm.org/cgi/content/abstract/JVI.01763-09v1
The Prostate Cancer-Associated Human Retrovirus XMRV Lacks Direct Transforming Activity but Can Induce Low Rates of Transformation in Cultured Cells
Michael J. Metzger, Christiana J. Holguin, Ramon Mendoza, and A. Dusty Miller
February 2010
Journal of Virology
http://jvi.asm.org/cgi/content/short/84/4/1874
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812358/pdf/1941-09.pdf
Retroviral infection in vivo requires an immune escape virulence factor encrypted in the envelope protein of oncoretroviruses
Schlecht-Louf G, Renard M, Mangeney M, Letzelter C, Richaud A, Ducos B, Bouallaga I, Heidmann T.
2010 Feb 23
PNAS
http://www.pnas.org/content/107/8/3782.long
Xenotropic Murine Leukemia Virus-Related Virus Establishes an Efficient Spreading Infection and Exhibits Enhanced Transcriptional Activity in Prostate Carcinoma Cells
Jason J. Rodriguez, and Stephen P. Goff
March 2010
Journal of Virology, March 2010, p. 2556-2562, Vol. 84, No. 5
http://jvi.asm.org/cgi/content/full/84/5/2556
Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors
Harriet C. T. Groom, Melvyn W. Yap, Rui Pedro Galo, Stuart J. D. Neil, and Kate N. Bishop.
16 March 2010
PNAS , doi: 10.1073/pnas.0913650107
http://www.pnas.org/content/107/11/5166.full
Inhibition of Xenotropic Murine Leukemia Virus-Related Virus by APOBEC3 Proteins and Antiviral Drugs
Tobias Paprotka, Narasimhan J. Venkatachari, Chawaree Chaipan, Ryan Burdick, Krista A. Delviks-Frankenberry, Wei-Shau Hu, and Vinay K. Pathak
24 March 2010
Journal of Virology
http://jvi.asm.org/cgi/content/abstract/JVI.00134-10v1
Host range and cellular tropism of the human exogenous gammaretrovirus XMRV.
Stieler K, Schulz C, Lavanya M, Aepfelbacher M, Stocking C, Fischer N.
2010 Mar 30
Virology
http://www.sciencedirect.com/science/article/pii/S0042682209008137
Raltegravir Is a Potent Inhibitor of XMRV, a Virus Implicated in Prostate Cancer and Chronic Fatigue Syndrome
Ila R. Singh, John E. Gorzynski, Daria Drobysheva, Leda Bassit, Raymond F. Schinazi
April 1, 2010
PLoS ONE
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009948
Evaluation of Cellular Determinants Required for In Vitro Xenotropic Murine Leukemia Virus-Related Virus Entry into Human Prostate Cancer and Noncancerous Cells
Sushma Bhosle, Suganthi Suppiah, Ross Molinaro, Yuying Liang, Rebecca Arnold, William Diehl, Natalia Makarova, Jerry Blackwell, John Petros, Dennis Liotta, Eric Hunter, and Hinh Ly
21 April 2010
Journal of Virology
http://jvi.asm.org/cgi/content/full...ld&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT
Prostate Cancer and Noncancerous Cells
Sushma Bhosle, Suganthi Suppiah, Ross Molinaro, Yuying Liang, Rebecca Arnold, William Diehl, Natalia Makarova, Jerry Blackwell, John Petros, Dennis Liotta, Eric Hunter, and Hinh Ly
21 April 2010
Journal of Virology
http://jvi.asm.org/cgi/content/full...ld&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT
Repeated Detection of Infectious Xenotropic Murine Virus-Related Virus (XMRV) in Human Neoplasia and Neuroimmune Diseases
Francis Ruscetti, Vincent Lombardi, Max Pfost, Kathryn Hagen, Judy Mikovits
26-27 April 2010
Unpublished - Presented at the 12th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI)
http://oham.cancer.gov/objects/pdf/2010ICMAOI_Program_Book.pdf
Characterization of retroviral and lentiviral vectors pseudotyped with xenotropic murine leukemia virus-related virus envelope glycoprotein
Sakuma T, De Ravin SS, Tonne JM, Thatava T, Ohmine S, Takeuchi Y, Malech HL, Ikeda Y.
May 27, 2010
Human Gene Therapy
http://www.liebertonline.com/doi/abs/10.1089/hum.2010.063
Apobec 3G Efficiently Reduces Infectivity of the Human Exogenous Gammaretrovirus XMRV
Kristin Stieler, Nicole Fischer
July 23, 2010
PLoS ONE
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0011738
Acutely transforming retrovirus expressing Nras generated from HT-1080 fibrosarcoma cells infected with the human retrovirus XMRV
Metzger MJ, Miller AD.
August 2010
Journal of Virology
http://jvi.asm.org/cgi/content/full/84/15/7908?view=long&pmid=20504941
Characterization of antibodies elicited by XMRV infection and development of immunoassays useful for epidemiologic studies
Xiaoxing Qiu, Priscilla Swanson, Ka-Cheung Luk, Bailin Tu, Francois Villinger, Jaydip Das Gupta, Robert H Silverman, Eric A Klein, Sushil Devare, Gerald Schochetman, John Hackett Jr
17 August 2010
Retrovirology 2010
http://www.retrovirology.com/content/pdf/1742-4690-7-68.pdf
Evolution of Functional and Sequence Variants of the Mammalian XPR1 Receptor for Mouse Xenotropic Gammaretroviruses and the Human-Derived Retrovirus XMRV
Yuhe Yan, Qingping Liu, Kurt Wollenberg, Carrie Martin, Alicia Buckler-White, and Christine A. Kozak
1 September 2010
Journal of Virology, Nov. 2010
http://jvi.asm.org/cgi/reprint/84/22/11970
Common Inbred Strains of the Laboratory Mouse That Are Susceptible to Infection by Mouse Xenotropic Gammaretroviruses and the Human-Derived Retrovirus XMRV
Surendranath Baliji, Qingping Liu,, and Christine A. Kozak
December 2010
Journal of Virology
http://jvi.asm.org/cgi/content/full/84/24/12841?view=long&pmid=20943975
Characterization of retroviral and lentiviral vectors pseudotyped with xenotropic murine leukemia virus-related virus envelope glycoprotein
Sakuma T, De Ravin SS, Tonne JM, Thatava T, Ohmine S, Takeuchi Y, Malech HL, Ikeda Y.
December 10, 2010
Human Gene Therapy
http://www.liebertonline.com/doi/abs/10.1089/hum.2010.063
Severe Restriction of Xenotropic Murine Leukemia Virus-Related Virus Replication and Spread in Cultured Human Peripheral Blood Mononuclear Cells
Chawaree Chaipan, Kari A. Dilley, Tobias Paprotka, Krista A. Delviks-Frankenberry, Narasimhan J. Venkatachari, Wei-Shau Hu, and Vinay K. Pathak*
2011 J. Virol. doi:10.1128/JVI.00046-11
Journal of Virology
http://jvi.asm.org/cgi/content/abstract/JVI.00046-11v1
Infection, viral dissemination and antibody responses of Rhesus macaques exposed to the human gammaretrovirus XMRV
Nattawat Onlamoon, Jaydip Das Gupta, Prachi Sharma, Kenneth Rogers, Suganthi Suppiah, Jeanne Rhea, Ross J. Molinaro, Christina Gaughan, Beihua Dong, Eric A. Klein, Xiaoxing Qiu, Sushil Devare, Gerald Schochetman, John Hackett Jr., Robert H Silverman, and Franois Villinger
2011 J. Virol. doi:10.1128/JVI.02411-10
http://jvi.asm.org/cgi/content/abstract/JVI.02411-10v1
NF-kB Activation Stimulates Transcription and Replication of Retrovirus XMRV in Human B-Lineage and Prostate Carcinoma Cells
Shuhei Sakakibara, Kaori Sakakibara,, and Giovanna Tosato
26 January 2011
Journal of Virology, April 2011, p. 3179-3186, Vol. 85, No. 7
http://jvi.asm.org/cgi/content/short/85/7/3179
Human APOBEC3 proteins can inhibit xenotropic murine leukemia virus-related virus infectivity
Hal P. Bogerd, Fengwen Zhang, Paul D. Bieniasz and Bryan R. Cullen
5 February 2011
Virology
http://www.sciencedirect.com/science/article/pii/S0042682210007270
Purify First: Rapid expression and purification of proteins from XMRV
William K. Gillette, Dominic Esposito, Troy E. Taylor, Ralph F. Hopkins, Rachel K. Bagni and James L. Hartley
April 2011
Protein Expression and Purification
http://www.sciencedirect.com/science/article/pii/S1046592810003414
Xmrv Infection Induces Host Genes That Regulate Inflammation And Cellular Physiology
Michael Lee, Elona Gusho, Jaydip Das Gupta, Eric Klein, Robert Silverman
April 2011
The Journal of Urology
(Unpublished abstract - presented at the American Urological Association meeting)
http://www.jurology.com/article/S0022-5347(11)00620-3/fulltext
Antibody Responses against Xenotropic Murine Leukemia Virus-Related Virus Envelope in a Murine Model
Natalia Makarova, Chunxia Zhao, Yuanyuan Zhang, Sushma Bhosle, Suganthi Suppiah, Jeanne M. Rhea, Natalia Kozyr, Rebecca S. Arnold, Hinh Ly, Ross J. Molinaro, Tristram G. Parslow, Eric Hunter, Dennis Liotta, John Petros, Jerry L. Blackwell
April 6, 2011
PLoS ONE
http://www.plosone.org/article/info...onid=159E155669BA4FC9765C02D8E1CDCFD3.ambra01
Xenotropic Murine Leukemia Virus-related Virus-associated Chronic Fatigue Syndrome Reveals a Distinct Inflammatory Signature
VINCENT C LOMBARDI, KATHRYN S HAGEN, KENNETH W HUNTER, JOHN W DIAMOND, JULIE SMITH-GAGEN, WEI YANG, and JUDY A. MIKOVITS
May-June 2011
in vivo 25: 307-314 (2011
http://iv.iiarjournals.org/content/25/3/307.abstract?etoc
Sexual transmission of XMRV:a potential infection route
Prachi Sharma, Kenneth Rogers, Suganthi Suppiah, Ross Ross Molinaro Ross J. Molinaro, Nattawat Onlamoon, J. Hackett Jr., G. Schochetman, Eric A. Klein, Robert Silverman, and F. Villinger
25 May 2011
Advances in Virology
http://www.hindawi.com/journals/av/aip/965689/
Naturally occurring polymorphisms of the mouse gammaretrovirus receptors CAT-1 and XPR1 alter virus tropism and pathogenicity
Christine A. Kozak
12 July 2011
Advances in Virology
http://www.hindawi.com/journals/av/aip/975801/
Frequent detection of infectious xenotropic murine leukemia virus (XMLV) in human cultures established from mouse xenografts
Yu-An Zhang, Anirban Maitra, Jer-Tsong Hsieh, Charles M. Rudin, Craig Peacock, Collins Karikari, Rolf A. Brekken, Victor Stastny, Boning Gao, Luc Girard, Ignacio Wistuba, Eugene Frenkel, John D. Minna and Adi F. Gazdar
October 1, 2011
Cancer Biology & Therapy Volume 12, Issue 7
https://www.landesbioscience.com/journals/5/article/15955/
https://www.landesbioscience.com/journals/cbt/ZhangCBT12-7.pdf
XMRV & CFS Patients - Published negative studies
Failure to Detect the Novel Retrovirus XMRV in Chronic Fatigue Syndrome
Otto Erlwein, Steve Kaye, Myra O. McClure, Jonathan Weber, Gillian Wills, David Collier, Simon Wessely, Anthony Cleare
January 6, 2010
PloS One
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0008519
Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome
Harriet CT Groom, Virginie C Boucherit, Kerry Makinson, Edward Randal, Sarah Baptista, Suzanne Hagan, John W Gow, Frank M Mattes, Judith Breuer, Jonathan R Kerr, Jonathan P Stoye, Kate N Bishop
15 February 2010
Retrovirology
http://www.retrovirology.com/content/7/1/10
Prevalence of xenotropic murine leukaemia virus-related virus in patients with chronic fatigue syndrome in the Netherlands: retrospective analysis of samples from an established cohort
Frank J M van Kuppeveld, Arjan S de Jong, Kjerstin H Lanke, Gerald W Verhaegh, Willem J G Melchers, Caroline M A Swanink, Gijs Bleijenberg, Mihai G Netea, Jochem M D Galama, Jos W M van der Meer
25 February 2010
BMJ
http://www.bmj.com/content/340/bmj.c1018.full
Absence of evidence of Xenotropic Murine Leukemia Virus-related virus infection in persons with Chronic Fatigue Syndrome and healthy controls in the United States
William M Switzer, Hongwei Jia, Oliver Hohn, HaoQiang Zheng, Shaohua Tang, Anupama Shankar, Norbert Bannert, Graham Simmons, R Michael Hendry, Virginia R Falkenberg, William C Reeves and Walid Heneine
1 July 2010
Retrovirology
http://www.retrovirology.com/content/7/1/57
Failure to detect Xenotropic murine leukaemia virus-related virus in Chinese patients with chronic fatigue syndrome
Ping Hong, Jinming Li, Yongzhe Li
13 September 2010
Virology Journal
http://www.virologyj.com/content/pdf/1743-422x-7-224.pdf
Xenotropic murine leukemia virus-related virus prevalence in patients with chronic fatigue syndrome or chronic immunomodulatory conditions
Henrich TJ, Li JZ, Felsenstein D, Kotton CN, Plenge RM, Pereyra F, Marty FM, Lin NH, Grazioso P, Crochiere DM, Eggers D, Kuritzkes DR, Tsibris AM.
2010 Nov 15
The Journal of Infectious Diseases
http://www.ncbi.nlm.nih.gov/pubmed/20936980
No Evidence for XMRV in German CFS and MS Patients with Fatigue Despite the Ability of the Virus to Infect Human Blood Cells In Vitro
Oliver Hohn, Kristin Strohschein, Alexander U. Brandt, Sandra Seeher, Sandra Klein, Reinhard Kurth, Friedemann Paul, Christian Meisel, Carmen Scheibenbogen, Norbert Bannert
December 22, 2010
PLoS ONE
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015632
Serologic and PCR testing of persons with chronic fatigue syndrome in the United States shows no association with xenotropic or polytropic murine leukemia virus-related viruses
Brent C Satterfield, Rebecca A Garcia, Hongwei Jia, Shaohua Tang, HaoQiang Zheng, and William M Switzer
22 February 2011
Retrovirology
http://www.retrovirology.com/content/8/1/12
Investigation into the Presence of and Serological Response to XMRV in CFS Patients
Otto Erlwein, Mark J. Robinson, Steve Kaye, Gillian Wills, Shozo Izui, Simon Wessely, Jonathan Weber, Anthony Cleare, David Collier, Myra O. McClure
March 9, 2011
PLoS ONE
http://www.plosone.org/article/info...onid=D53FC24B8C7988B2019B952378A8CB06.ambra02
No association of xenotropic murine leukemia virus-related virus with prostate cancer or chronic fatigue syndrome in Japan
Rika A Furuta, Takayuki Miyazawa, Takeki Sugiyama, Hirohiko Kuratsune, Yasuhiro Ikeda, Eiji Sato, Naoko Misawa, Yasuhito Nakatomi, Ryuta Sakuma, Kazuta Yasui, Kouzi Yamaguti, and Fumiya Hirayama
17 March 2011
Retrovirology
http://www.retrovirology.com/content/8/1/20
Analysis of cerebrospinal fluid from chronic fatigue syndrome patients for multiple human ubiquitous viruses and xenotropic murine leukemia-related virus
Steven E Schutzer MD, Megan A Rounds M, Benjamin H Natelson MD, David J Ecker PhD, Mark W Eshoo PhD
6 April 2011
Annals of Neurology
http://onlinelibrary.wiley.com/doi/10.1002/ana.22389/abstract
Absence of XMRV and other MLV-related viruses in patients with Chronic Fatigue Syndrome
Clifford H. Shin, Lucinda Bateman, Robert Schlaberg, Ashley M. Bunker, Christopher J. Leonard, Ronald W. Hughen, Alan R. Light, Kathleen C. Light, and Ila R. Singh
4 May 2011
Journal of Virology
http://jvi.asm.org/cgi/content/abstract/JVI.00693-11v1
No Evidence of Murine-Like Gammaretroviruses in CFS Patients Previously
Identified as XMRV-Infected
Konstance Knox, Donald Carrigan, Graham Simmons, Fernando Teque,Yanchen Zhou, John Hackett Jr.,Xiaoxing Qiu, Ka-Cheung Luk, Gerald Schochetman, Allyn Knox, Andreas M. Kogelnik, Jay A. Levy
31 May 2011
Sciencexpress
http://www.sciencemag.org/content/early/2011/05/31/science.1204963.full.pdf
Failure to detect XMRV-specific antibodies in the plasma of CFS patients using Highly Sensitive Chemiluminescence Immunoassays
Brendan Oakes, Xiaoxing Qiu, Susan Levine, J. Hackett Jr., and Brigitte Huber
10 June 2011
Advances in Virology
http://www.hindawi.com/journals/av/aip/854540/
Xenotropic murine leukemia virus-related virus in monozygotic twins discordant for chronic fatigue syndrome
Jerome KR, Diem K, Huang ML, Selke S, Corey L, Buchwald D.
Diagnostic Microbiology and Infectious Disease
doi:10.1016/j.diagmicrobio.2011.06.003
26 July 2011
http://www.ncbi.nlm.nih.gov/pubmed/21795004
Inconclusive studies & studies that add some knowledge about XMRV
No Association of Xenotropic Murine Leukemia Virus-Related Viruses with Prostate Cancer
William M. Switzer, Hongwei Jia, HaoQiang Zheng, Shaohua Tang, Walid Heneine
May 4, 2011
PLoS ONE
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0019065#abstract0
("Also, the finding of a viral strain in three prostate cancer patients that is distinct from the XMRV seen in previous studies is significant and demonstrates a broader viral diversity. This would be an expected result consistent with virus evolution during spread and persistence.")
Overviews of XMRV Research
A Scientific Journey Through the 2-5A/RNase L System
Robert H. Silverman
2007
Cytokine Growth Factor Rev. 2007
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075094/pdf/nihms30420.pdf
http://www.ncbi.nlm.nih.gov/pubmed/17681844
Implications for XMRV Infections In Prostate Cancer
Seunghee Hong
January, 2010
Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy
Department of Molecular Biology and Microbiology
Molecular Virology Program
Case Western Reserve University
http://etd.ohiolink.edu/send-pdf.cgi/Hong Seunghee.pdf?case1251739728
The human retrovirus XMRV in prostate cancer and chronic fatigue syndrome
Robert H. Silverman, Carvell Nguyen, Christopher J. Weight & Eric A. Klein
1 June 2010
Nature Reviews Urology
http://www.nature.com/nrurol/journal/v7/n7/abs/nrurol.2010.77.html
Biology and pathophysiology of the new human retrovirus XMRV and its association with human disease
Alice Rusmevichientong and Samson A. Chow
August 18, 2010
Immunological Research
http://www.springerlink.com/content/w07qx0236q801q39/
The mouse xenotropic gammaretroviruses and their XPR1 receptor
Christine A Kozak
30 November 2010
Retrovirology 2010
http://www.retrovirology.com/content/pdf/1742-4690-7-101.pdf
Of mice and men: on the origin of XMRV (Article)
Antoinette Cornelia van der Kuyl, Marion Cornelissen and Ben Berkhout
17 January 2011
Frontier in Virology
http://www.frontiersin.org/virology/10.3389/fmicb.2010.00147/full
XMRV Discovery and Prostate Cancer Related Research
David Kang, Michael Lee, Jaydip Das Gupta, Eric A. Klein, and R. H. Silverman
25 May 2011
Advances in Virology
http://www.hindawi.com/journals/av/aip/432837/
http://downloads.mts.hindawi.com/MTS-Files/AV/papers/XMLV/432837.v2.pdf
Human infection or lab artifact: will the real XMRV please stand up? (Abstract only)
Silverman
6 June 2011
Presentation from the "15th International Conference on Human Retroviruses: HTLV and Related Viruses"
http://www.retrovirology.com/content/8/S1/A241
http://www.retrovirology.com/content/pdf/1742-4690-8-S1-A241.pdf
Testing Strategies for Detection of Xenotropic Murine Leukemia Virus Related Virus (XMRV) Infection
Shixing Tang and Indira K. Hewlett
10 June 2011
Advances in Virology
http://www.hindawi.com/journals/av/aip/281425/
Phylogeny-directed search for murine leukemia virus - like retroviruses in vertebrate genomes, and in patients suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Prostate Cancer
J. Blomberg, Ali Sheikholvaezin, Amal Elfaitouri, Fredrik Blomberg, Anna Sjsten, Johan Mattson Ulfstedt, Rudiger Pipkorn, Klas Kllander, Christina hrmalm, and Gran Sperber.
22 June 2011
Advances in Virology
http://www.hindawi.com/journals/av/aip/341294/
Reviews
Distribution of Xenotropic Murine Leukemia Virus-Related Virus (XMRV) Infection in Chronic Fatigue Syndrome and Prostate Cancer
Judy A.Mikovits, Ying Huang, Max A.Pfost, Vincent C.Lombardi, Daniel C.Bertolette, Kathryn S.Hagen, and Francis W.Ruscetti.
2010
AIDS Review
http://www.aidsreviews.com/files/2010_12_3_149-152.pdf
Detecting Retroviral Sequences in Chronic Fatigue Syndrome
Ila R. Singh
3 November 2010
Viruses 2010
http://www.mdpi.com/1999-4915/2/11/2404/pdf
Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples
J. M. Coffin and Oya Cingz
Advances in Virology
7 July 2011
http://www.hindawi.com/journals/av/aip/940210/
Letters to Scientific Journals
Mouse viruses and human disease (Letter)
Gkikas Magiorkinis
April 2011 doi:10.1016/S1473-3099(11)70081-0
The Lancet Infectious Diseases
http://www.thelancet.com/journals/l...lsca1=TLID-290311&elsca2=email&elsca3=segment
Mouse viruses and human disease (Letter)
Alexandre FR Stewart, D William Cameron
April 2011 doi:10.1016/S1473-3099(11)70082-2
The Lancet Infectious Diseases
http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(11)70082-2/fulltext
Blood Related Studies & Reviews
Xenotropic murine leukemia virusrelated virus (XMRV) and blood transfusion: report of the AABB interorganizational XMRV task force
Harvey G. Klein, Roger Y. Dodd, F. Blaine Hollinger, Louis M. Katz, Steven Kleinman,
K. Kimberly McCleary, Robert H. Silverman, and Susan L. Stramer
- for the AABB Interorganizational Task Force on XMRV
51, March 2011
Transfusion
http://www.aabb.org/pressroom/Documents/xmrvcommrpt011811.pdf
The Blood Xenotropic Murine Leukemia VirusRelated Virus Scientific Research Working Group: mission, progress, and plans
Graham Simmons, Simone A. Glynn, Jerry A. Holmberg, John M. Coffin, Indira K. Hewlett, Shyh-Ching Lo, Judy A. Mikovits, William M. Switzer, Jeffrey M. Linnen, Michael P. Busch
- for the Blood XMRV Scientific Research Working Group
1 March 2011
Transfusion
http://onlinelibrary.wiley.com/doi/10.1111/j.1537-2995.2011.03063.x/abstract
XMRV, Q fever and other emerging infections: impact on management of blood safety
R. Y. Dodd
2011
2011 International Society of Blood Transfusion,
ISBT Science Series (2011) 6, 11912
http://onlinelibrary.wiley.com/doi/10.1111/j.1751-2824.2011.01454.x/pdf
AABB XMRV information sheet:
http://www.aabb.org/resources/bct/eid/Documents/xmrvfactsheet.pdf
PCR Master Mixes Harbour Murine DNA Sequences. Caveat Emptor!
Philip W. Tuke, Kate I. Tettmar, Asif Tamuri, Jonathan P. Stoye, Richard S. Tedder.
May 25, 2011
PLoS ONE
http://www.plosone.org/article/fetc...icleURI=info:doi/10.1371/journal.pone.0019953
No Evidence of XMRV or MuLV Sequences in Prostate Cancer, Diffuse Large B-Cell Lymphoma, or the UK Blood Donor Population
Mark James Robinson, Philip William Tuke, Otto Erlwein, Kate I. Tettmar, Steve Kaye, Kikkeri N. Naresh, Anup Patel, Marjorie M. Walker, Takahiro Kimura, Ganesh Gopalakrishnan, Richard S. Tedder, and Myra O. McClure
31 March 2011
Advances in Virology doi:10.1155/2012/782353
http://www.hindawi.com/journals/av/2011/782353/
Patents applied for
Compositions And Methods Relating To Xmrv-Related Diseases And Conditions
Singh, Ila Ramnaresh; (US). Thaker, Harshwardhan Manohar; (US). Schlaberg, Robert; (US). Shin, Clifford; (US)
The University Of Utah Research Foundation
(XMRV in breast cancer)
Patent:
http://www.wipo.int/patentscope/search/en/WO2010132886
Info:
http://www.facebook.com/notes/xmrv-...s-on-xmrv-breast-cancer-prostate/472237776796
Diagnosis And Treatment Of Diseases Or Disorders Associated With Xenotropic Murine Leukemia Virus-Related Virus
MIKOVITS, Judy, A.; (US). LOMBARDI, Vincent, C.; (US). RUSCETTI, Sandra, K.; (US). RUSCETTI, Francis, W.; (US)
WPI
Methods of detecting XMRV, and diagnosing XMRV-related illnesses etc.
http://www.wipo.int/patentscope/sea...lter=&sortOption=&queryString=&tab=PCT+Biblio
Detection Of Xenotropic Murine Leukemia Virus
Mikovits; Judy A.; (Reno, NV) ; Lombardi; Vincent; (Reno, NV) ; Ruscetti; Sandra; (New Market, MD) ; Ruscetti; Francis; (New Market, MD) ; Silverman; Robert; (Beachwood, OH)
WPI
"Methods of detecting, diagnosing, monitoring or managing an XMRV-related neuroimmune disease such as chronic fatigue syndrome or XMRV-related lymphoma such as mantle cell lymphoma in a subject are disclosed."
June 23, 2011
http://www.freepatentsonline.com/y2011/0151431.html
http://appft.uspto.gov/netacgi/nph-...ND&d=PG01&s1=mikovits&OS=mikovits&RS=mikovits
Positive XMRV Prostate Cancer studies
Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant.
Urisman A, Molinaro RJ, Fischer N, Plummer SJ, Casey G, Klein EA, Malathi K, Magi-Galluzzi C, Tubbs RR, Ganem D, Silverman RH, DeRisi JL.
31st March 2006
http://www.ncbi.nlm.nih.gov/pubmed/16609730?dopt=Abstract&holding=f1000,f1000m,isrctn
(XMRV was first discovered in 2006 in prostate cancer patients. This is the original XMRV paper)
(Results: XMRV in QQ genotype = 40%, XMRV in RQ + RR genotypes = 1.5%, Healthy controls = not tested.)
XMRV is present in malignant prostatic epithelium and is associated with prostate cancer, especially high-grade tumors
Robert Schlaberga, Daniel J. Choeb, Kristy R. Browna, Harshwardhan M. Thakerb and Ila R. Singh,
September 8, 2009
PNAS
http://www.pnas.org/content/early/2009/09/04/0906922106.abstract
(Results: XMRV in prostate cancer tissue by IHC = 23%. XMRV in benign tissue controls by IHC = 4%)
XMRV infection in patients with prostate cancer: novel serologic assay and correlation with PCR and FISH.
Arnold RS, Makarova NV, Osunkoya AO, Suppiah S, Scott TA, Johnson NA, Bhosle SM, Liotta D, Hunter E, Marshall FF, Ly H, Molinaro RJ, Blackwell JL, Petros JA.
April 2010
Urology
http://www.goldjournal.net/article/S0090-4295(10)00117-2/abstract
(Results: XMRV in QQ genotype tested for XMRV antibodies = 40%, XMRV in either RQ or RR genotype = 15%, Healthy controls = not tested.)
Detection of xenotropic murine leukemia virus-related virus in normal and tumor tissue of patients from the southern United States with prostate cancer is dependent on specific polymerase chain reaction conditions
Danielson BP, Ayala GE, Kimata JT.
Nov 2010.
The Journal of Infection Diseases
http://www.ncbi.nlm.nih.gov/pubmed/20936978
(Results: XMRV detected in 22% of prostate cancer patients, in normal and tumour prostate tissue, independent of genotype. Healthy controls not tested.)
Unpublished Positive XMRV Prostate Cancer studies
Xenotropic Murine Leukemia Virus Related Virus (Xmrv) Is Present In Malignant Prostate Tissue But Does Not Affect Pathological Or Clinical Outcome
Chad Ritch, Ruslan Korets, Mireia Castillo-Martin, Josep Domingo-Domenech, Mitchell Benson, Carlos Cordon-Cardo
April 2011
The Journal of Urology (Abstract presented at the American Urological Association meeting)
http://www.jurology.com/article/S0022-5347(11)01618-1/fulltext
Immunofluorescence: XMRV detected in 33/65 (51%) of malignant samples, and in only 5/42 benign samples (12%).
PCR: XMRV detected 14/65 (21%) of prostate cancer samples, and 2/42 (5%) in benign tissue
Combined PCR and IF: XMRV was detected in at least 17% of malignant samples and rarely found in benign tissue.
A Preliminary Screening Of Xenotropic Murine Leukemia Virus-Related Virus In Japanese Prostate Cancer Patients
Tsukasa Igawa, Yoshinao Kubo, Katsura Kakoki, Naoki Yamamoto, Hideki Sakai
April 2011
The Journal of Urology (Abstract presented at the American Urological Association meeting)
http://www.jurology.com/article/S0022-5347(11)01208-0/fulltext
(MLV sequences were detected in four out of sixty one patients (6.7%))
Inconclusive & No Association XMRV Prostate Cancer studies (Some XMRV detected)
Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer.
Fischer N, Hellwinkel O, Schulz C, Chun FK, Huland H, Aepfelbacher M, Schlomm T.
2008 Nov (published online 29 September 2008)
J Clin Virol. 2008 Nov;43(3):277-83. Epub 2008 Sep 27.
http://www.journalofclinicalvirology.com/article/S1386-6532(08)00301-6/abstract
(Results: XMRV in prostate cancer = 0.95% XMRV in healthy controls = 1.4%)
Identification of viral infections in the prostate and evaluation of their association with cancer
Martinez-Fierro ML, Leach RJ, Gomez-Guerra LS, Garza-Guajardo R, Johnson-Pais T, Beuten J, Morales-Rodriguez IB, Hernandez-Ordoez MA, Calderon-Cardenas G, Ortiz-Lopez R, Rivas-Estilla AM, Ancer-Rodriguez J, Rojas-Martinez A.
24 June 2010
BMC Cancer
http://www.biomedcentral.com/1471-2407/10/326/
(Results: XMRV in prostate cancer tissue=0. XMRV in normal controls = 1.3%)
Prevalence of human xenotropic murine leukemia virus-related gammaretrovirus (XMRV) in Dutch prostate cancer patients.
Verhaegh GW, de Jong AS, Smit FP, Jannink SA, Melchers WJ, Schalken JA.
March 2011
http://www.ncbi.nlm.nih.gov/pubmed/20878949
(Results: XMRV sequences were detected in 3 out of 74 (i.e., 4%) PrCa specimens.)
No association of xenotropic murine leukemia virus-related virus with prostate cancer or chronic fatigue syndrome in Japan
Furuta RA, Miyazawa T, Sugiyama T, Kuratsune H, Ikeda Y, Sato E, Misawa N, Nakatomi Y, Sakuma R, Yasui K, Yamaguti K, Hirayama F.
17th March 2011
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065418/
No evidence of XMRV in prostate cancer cohorts in the Midwestern United States
Toshie Sakuma, Stphane Hu , Karen A Squillace , Jason M Tonne , Patrick R Blackburn , Seiga Ohmine , Tayaramma Thatava , Greg J Towers and Yasuhiro Ikeda.
29 March 2011
Retrovirology 2011, 8:23doi:10.1186/1742-4690-8-23
http://www.retrovirology.com/content/8/1/23
No Association of Xenotropic Murine Leukemia Virus-Related Viruses with Prostate Cancer
William M. Switzer, Hongwei Jia, HaoQiang Zheng, Shaohua Tang, Walid Heneine
May 4, 2011
PLoS ONE
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0019065#abstract0
(Results: XMRV in prostate cancer = 1.9%)
continued in next post.....
I've aimed to make this a comprehensive list, hopefully including all of the high profile studies relating to XMRV/CFS, but there maybe studies that I've overlooked.
Any suggestions for additional info, corrections and improvements are very welcome.
Within each category, the papers are listed in order of the date of publication.
Contents:
XMRV in CFS Patients - Published positive studies
PMRV in CFS Patients - Published positive studies
XMRV in CFS Patients - unpublished positive studies abstracts & reports
XMRV in CFS Patients - future studies
Other published positive XMRV studies (Not CFS or Prostate cancer)
Other unpublished positive XMRV & PMRV studies (Not CFS or Prostate cancer)
XMRV/Human DNA integration papers
Conferences - and lists of abstracts
Investigative XMRV studies
XMRV & CFS Patients - Published negative studies
Inconclusive studies & studies that add some knowledge about XMRV
Overviews of XMRV research
Reviews
Letters to Scientific Journals
Blood Related Studies & Reviews
Patents applied for
Positive XMRV Prostate Cancer studies
Unpublished Positive XMRV Prostate Cancer studies
Inconclusive & No Association XMRV Prostate Cancer studies (Some XMRV detected)
Negative XMRV Prostate Cancer Studies (No XMRV detected)
Negative XMRV studies other
Contamination studies and theories
Papers that provide evidence against contamination theories
MLV Recombination Theory studies
Other negative studies (Not CFS or Prostate cancer)
Science Journal editorial Expression of Concern.
Historical research looking at MLV-related viruses associated with human disease
Antiretroviral Research
Related/Relevant HIV Research
Related/Relevant HTLV Research
Other research related to XMRV/CFS
XMRV Sequences in genbank
Other information
Comparison Tables XMRV research studies
Conference Abstracts (A small selection of abstracts)
Student Theses relating to XMRV
Other resources
XMRV in CFS Patients - Published positive studies
Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome
Vincent C. Lombardi, Francis W. Ruscetti, Jaydip Das Gupta, Max A. Pfost, Kathryn S. Hagen, Daniel L. Peterson, Sandra K. Ruscetti, Rachel K. Bagni, Cari Petrow-Sadowski, Bert Gold, Michael Dean, Robert H. Silverman, and Judy A. Mikovits
Published Online 8 October 2009
Published in Science 23 October 2009
Science
http://www.sciencemag.org/content/326/5952/585.abstract
Addendum:
http://www.landesbioscience.com/journals/virulence/MikovitisVIRU1-5.pdf
Supplementary material:
http://www.ncbi.nlm.nih.gov/pubmed/20842203
PMRV in CFS Patients - Published positive studies
Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors
Shyh-Ching Lo, Natalia Pripuzova, Bingjie Li, Anthony L. Komaroff, Guo-Chiuan Hung, Richard Wang, and Harvey J. Alter
Published online before print August 23, 2010
PNAS
http://www.pnas.org/content/early/2010/08/16/1006901107.full.pdf+html
Results: 86.5% in CFS patients. 6.8% in healthy volunteer blood donors.
XMRV in CFS Patients unpublished positive studies abstracts & reports
Anything other studies to add here?
Detection of infectious XMRV in the peripheral blood of children
M A Pfost et al.
(WPI)
Looking for XMRV in families and testing: adults with ME, FM, Lymme disease; Parents of children with neuroimmune disease; children with ASD; children with Niemann-Pick; and healthy children with sibling who have neuroimmune disease. Positive results obtained.
http://regist2.virology-education.com/abstractbook/2010_8.pdf
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
Detection of infectious XMRV in the peripheral blood of chronic fatigue syndrome patients in the United Kingdom.
Mikovits et al.
(WPI)
Initial results reported to be about 80% positive for XMRV in UK ME patients, and 6-8% positive in the UK blood supply.
http://regist2.virology-education.com/abstractbook/2010_8.pdf
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
XMRV detection in a national practice specializing in CFS
P Cheney
Using the VIPdx lab, 74.5% of consecutive ME patients, who went to the Cheney Clinic, tested positive for XMRV.
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
Detection of MLV-like gag sequences in blood samples from a New York state CFS cohort
Maureen R Hanson, Li L Lee, Lin Lin, David E Bell, David Ruppert and David S Bell
Initial reported results = 80% of 10 patients currently meeting Fukuda criteria tested positive for MLV-related sequences, and 1% of healthy controls. (Reportedly finding PMRV rather than XMRV.)
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
http://www.cfids.org/xmrv/wrkshp-report.pdf
http://www.biomedcentral.com/content/files/pdf/1742-4690-8-S1-full.pdf
http://www.retrovirology.com/content/8/S1/A234
An extract from:
Of Mice and Men: A Summary of the First International XMRV Workshop.
by K. Kimberly McCleary with Steven H. Kleinman, BSc, MD, and Suzanne D. Vernon, PhD.
Dr. Hansons study tested samples obtained by David S. Bell from 20 CFS patients, 10 of whom reported having recovered but still demonstrated lower physical activity levels than the 10 healthy control subjects as measured by seven instruments employed by Dr. Bell. Of these 20 CFS patients, 11 (55%) were positive; 8 (80%) of the 10 patients currently meeting Fukuda criteria and 3 (30%) of the individuals who had recovered tested positive, compared to 1 (10%) of the 10 healthy controls. The gag sequences found by Dr. Hanson were more similar to those reported by Lo et al., than to the gag sequences for XMRV, although all are part of the same gammaretrovirus family. Her group is working to sequence the env sequence and the entire virus genome(s) now that they have external funding support from NIH.
http://www.cfids.org/xmrv/wrkshp-report.pdf
Kenny De Meirlier
Blinded study, using the VIPdx to test for XMRV
Initial reported results = XMRV detected in 57% of 84 CFS patients, and in 14% of 50 healthy donors.
http://www.investinme.org/IiME Conf...onal ME Conference 2011 Conference Report.htm
Wilfried Bieger (Germany)
Reported positive study, to be published sometime in 2011.
Detecting XMRV in 20% to 40% of 110 CFS patient samples.
http://www.investinme.org/IiME Conf...onal ME Conference 2011 Conference Report.htm
http://www.facebook.com/notes/xmrv-...-40-of-a-cohort-of-110-peop/10150253684766797
XMRV in CFS Patients - Future studies
The Norwegian study of CFS, NO-CFS, Stage 1: Confirmatory study for the detection on Gamma-retrovirus related Gene Sequences.
http://esme-eu.com/news/the-norwegi...irus-related-gene-sequences-article487-7.html
http://lhkpasientfora.org/wp-conten...krivelse_eng_NO_CFS_stage-one_XMRV-study1.pdf
Blood Working Group
link to info needed
Ian Lipkin
link to info needed
Dr. Frank Maldarelli
NIH - National Cancer Institute
The study will take blood samples from 60 people, divided equally between people who previously tested XMRV-positive and healthy individuals.
The data will be used to help formulate a gold standard for determining positive and negative results.
http://www.phillyburbs.com/blogs/wo...b-7981-56f2-b829-af35a545728e.html?mode=print
Other published positive XMRV studies (Not CFS or Prostate cancer)
Xenotropic Murine Leukemia Virusrelated Gammaretrovirus in Respiratory Tract
Nicole Fischer, Claudia Schulz, Kristin Stieler, Oliver Hohn, Christoph Lange, Christian Drosten, and Martin Aepfelbacher
June 2010
Emerg Infect Dis. 2010 Jun; DOI: 10.3201/eid1606.100066
http://www.cdc.gov/eid/content/16/6/1000.htm
(We detected XMRV in respiratory secretions of immunocompetent patients with and without RTI at a frequency of ?3.2%, which is in good concordance with the recently reported prevalence in the general population of up to 4%)
The Prevalence of XMRV in Healthy Blood Donors in Japan
XMRV reportedly found in 1.7% of random healthy blood donor samples from the blood supply in Japan, testing for antibodies only. (This was a study of blood bank samples and prostate cancer patients, not ME patients.)
"Although our study had a limited sample size, the prevalence among blood donors as determined by identifying XMRV-specific antibodies was found to be 1.7%, while that among prostate cancer patients was found to be 6.3%"
(Publication status unknown to me)
http://www.diagnosesupport.com/heal...ted-virus-in&catid=132:xmrv-research&Itemid=8
Other unpublished positive XMRV & PMRV studies (Not CFS or Prostate cancer)
Detection of infectious XMRV in the peripheral blood of children
M A Pfost et al. (WPI)
Looking for XMRV in families and testing: adults with ME, FM, Lymme disease; Parents of children with neuroimmune disease; children with ASD; children with Niemann-Pick; and healthy children with sibling who have neuroimmune disease. Positive results obtained.
http://regist2.virology-education.com/abstractbook/2010_8.pdf
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
Compositions And Methods Relating To Xmrv-Related Diseases And Conditions
Singh, Ila Ramnaresh; (US). Thaker, Harshwardhan Manohar; (US). Schlaberg, Robert; (US). Shin, Clifford; (US)
The University Of Utah Research Foundation
(XMRV in breast cancer)
Patent:
http://www.wipo.int/patentscope/search/en/WO2010132886
Info:
http://www.facebook.com/notes/xmrv-...s-on-xmrv-breast-cancer-prostate/472237776796
XMRV proviral DNA sequences or XMRV proteins were detected in approximately 25% of 178 breast cancer samples.
XMRV/Human DNA integration papers
Integration Site Preference of Xenotropic Murine Leukemia Virus-Related Virus, a New Human Retrovirus Associated with Prostate Cancer
Sanggu Kim, Namshin Kim, Beihua Dong, David Boren, Serena A. Lee, Jaydip Das Gupta, Christina Gaughan, Eric A. Klein, Christopher Lee, Robert H. Silverman, and Samson A. Chow
3 August 2008
Journal Of Virology, Oct. 2008
http://jvi.asm.org/cgi/reprint/82/20/9964
Multiple Integrated Copies and High-Level Production of the Human Retrovirus XMRV (Xenotropic Murine Leukemia Virus-Related Virus) from 22Rv1 Prostate Carcinoma Cells
Emily C. Knouf, Michael J. Metzger, Patrick S. Mitchell, Jason D. Arroyo, John R. Chevillet,
Muneesh Tewari, and A. Dusty Miller*
23 April 2009
Journal Of Virology, July 2009,
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704771/pdf/0546-09.pdf
Fidelity of target site duplication and sequence preference during integration of xenotropic murine leukemia virus-related virus.
Kim S, Rusmevichientong A, Dong B, Remenyi R, Silverman RH, Chow SA
April 20, 2010
PloS ONE
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010255
Deciphering the Code for Retroviral Integration Target Site Selection
Federico Andrea Santoni, Oliver Hartley, Jeremy Luban
November 24, 2010
PLoS Computational Biology
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991247/pdf/pcbi.1001008.pdf
Analysis of XMRV integration sites from human prostate cancer tissues suggests PCR contamination rather than genuine human infection.
Garson JA, Kellam P, Towers GJ.
25 February 2011
Retrovirology
http://www.retrovirology.com/content/8/1/13
Conferences - and lists of abstracts
CROI 2010 - 17th Conference on Retroviruses and Opportunistic Infections
February 16-19, 2010
XMRV related abstracts:
http://www.cfids.org/xmrv/croi-2010.asp
Program:
http://zika.retroconference.org/croi-2010-pocket-program.pdf
12th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI)
NCI. NIH. Office of HIV and AIDS Malignancy.
26-27 April 2010
http://www.capconcorp.com/meeting/12thICMAOI/agenda.asp
http://oham.cancer.gov/objects/pdf/2010ICMAOI_Program_Book.pdf
1st International Workshop on XMRV
The abstracts of the 1st International Workshop on XMRV are published in Reviews in Antiviral Therapy & Infectious Diseases 2010_8
7-8th September 2010
http://www.virology-education.com/i...erial/vid/1A5D65BD-FB8B-8AE1-5E10829372D080B4
Official Abstract Book:
http://regist2.virology-education.com/abstractbook/2010_8.pdf
List of Abstracts:
http://www.mecfsforums.com/wiki/Abstracts_from_1st_International_Workshop_on_XMRV
Oral and Poster presentations Table of results:
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
CROI 2011 - 18th Conference on Retroviruses and Opportunistic Infections
Feb 27 - 2nd March 2011
http://www.cfids.org/xmrv/croi-2011.asp
http://www.retroconference.org/2011/data/files/ProgramAtAGlance_11.pdf
American Urological Association meeting
April 2011
The Journal of Urology
http://www.jurology.com/article/S0022-5347(11)01618-1/fulltext
http://www.jurology.com/article/S0022-5347(11)01208-0/fulltext
http://www.jurology.com/article/S0022-5347(11)00620-3/fulltext
NIH State Of Knowledge (SOK) Workshop - Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Research
April 7-8, 2011
Website:
http://orwh.od.nih.gov/CSF 2011/newsEvents.htm
Agenda:
http://orwh.od.nih.gov/SOK AGENDA - Final.pdf
Video - Day 1
http://videocast.nih.gov/launch.asp?16575
Video - Day 2:
http://videocast.nih.gov/launch.asp?16571
American Urological Association meeting
April 2011
The Journal of Urology
http://www.jurology.com/article/S0022-5347(11)01618-1/fulltext
http://www.jurology.com/article/S0022-5347(11)01208-0/fulltext
http://www.jurology.com/article/S0022-5347(11)00620-3/fulltext
Invest in ME Conference 2011 (No abstracts presented)
The 6th Invest in ME International ME/CFS Conference 2011
20th May 2011
Conference Report by Rosamund Vallings of the Associated New Zealand ME Society:
http://www.investinme.org/IiME Conf...onal ME Conference 2011 Conference Report.htm
15th International Conference on Human Retrovirology: HTLV and Related Retroviruses
Saturday, June 4, 2011 to Wednesday, June 8, 2011
http://forums.phoenixrising.me/show...ce+on+Human+Retrovirology+-+List+of+Abstracts
http://www.research1st.com/2011/06/08/15th-htlvconf/
Investigative XMRV studies (Just a selection) (Please see conference abstracts for ongoing studies)
An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors
Beihua Dong, Sanggu Kim, Seunghee Hong, Jaydip Das Gupta, Krishnamurthy Malathi, Eric A. Klein, Don Ganem, Joseph L. DeRisi, Samson A. Chow, and Robert H. Silverman
November 27, 2006
PNAS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1776164/pdf/zpq1655.pdf
Quantification of reverse transcriptase in ALS and elimination of a novel retroviral candidate
A. L. McCormick, PhD, R. H. Brown Jr, MD, DPhil, M. E. Cudkowicz, MD, MSc, A. Al-Chalabi, PhD, FRCP and J. A. Garson, MD, PhD
July 18, 2007.
Neurology January 22, 2008
http://www.neurology.org/content/70/4/278.short
Molecular evolution of the prostate cancer susceptibility locus RNASEL: Evidence for positive selection
Kyle Summers, and Bernard Crespi
May 2008
Infection, Genetics and Evolution
http://www.sciencedirect.com/science/article/pii/S1567134808000075
A Natural Human Retrovirus Efficiently Complements Vectors Based on Murine Leukemia Virus
Beihua Dong, Robert H. Silverman, Eugene S. Kandel
September 4, 2008
PLoS ONE
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519784/pdf/pone.0003144.pdf
Fibrils of Prostatic Acid Phosphatase Fragments Boost Infections with XMRV (Xenotropic Murine Leukemia Virus-Related Virus), a Human Retrovirus Associated with Prostate Cancer
Seunghee Hong, Eric A. Klein, Jaydip Das Gupta, Kirsten Hanke, Christopher J. Weight, Carvell Nguyen, Christina Gaughan, Kyeong-Ae Kim, Norbert Bannert, Frank Kirchhoff, Jan Munch, and Robert H. Silverman
21 April 2009
JOURNAL OF VIROLOGY, July 2009
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704761/pdf/0268-09.pdf
Kyeong-Ae Kim, Norbert Bannert, Frank Kirchhoff, Jan Munch, and Robert H. Silverman
21 April 2009
JOURNAL OF VIROLOGY, July 2009
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704761/pdf/0268-09.pdf
Six host range variants of the xenotropic/polytropic gammaretroviruses define determinants for entry in the XPR1 cell surface receptor
Yuhe Yan, Qingping Liu and Christine A Kozak
7 October 2009
Retrovirology
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768677/pdf/1742-4690-6-87.pdf
Androgen Stimulates Transcription and Replication of XMRV (Xenotropic Murine Leukemia Virus-Related Virus)
Beihua Dong and Robert H. Silverman
11 November 2009
Journal of Virology
http://jvi.asm.org/cgi/content/abstract/JVI.01763-09v1
The Prostate Cancer-Associated Human Retrovirus XMRV Lacks Direct Transforming Activity but Can Induce Low Rates of Transformation in Cultured Cells
Michael J. Metzger, Christiana J. Holguin, Ramon Mendoza, and A. Dusty Miller
February 2010
Journal of Virology
http://jvi.asm.org/cgi/content/short/84/4/1874
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812358/pdf/1941-09.pdf
Retroviral infection in vivo requires an immune escape virulence factor encrypted in the envelope protein of oncoretroviruses
Schlecht-Louf G, Renard M, Mangeney M, Letzelter C, Richaud A, Ducos B, Bouallaga I, Heidmann T.
2010 Feb 23
PNAS
http://www.pnas.org/content/107/8/3782.long
Xenotropic Murine Leukemia Virus-Related Virus Establishes an Efficient Spreading Infection and Exhibits Enhanced Transcriptional Activity in Prostate Carcinoma Cells
Jason J. Rodriguez, and Stephen P. Goff
March 2010
Journal of Virology, March 2010, p. 2556-2562, Vol. 84, No. 5
http://jvi.asm.org/cgi/content/full/84/5/2556
Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors
Harriet C. T. Groom, Melvyn W. Yap, Rui Pedro Galo, Stuart J. D. Neil, and Kate N. Bishop.
16 March 2010
PNAS , doi: 10.1073/pnas.0913650107
http://www.pnas.org/content/107/11/5166.full
Inhibition of Xenotropic Murine Leukemia Virus-Related Virus by APOBEC3 Proteins and Antiviral Drugs
Tobias Paprotka, Narasimhan J. Venkatachari, Chawaree Chaipan, Ryan Burdick, Krista A. Delviks-Frankenberry, Wei-Shau Hu, and Vinay K. Pathak
24 March 2010
Journal of Virology
http://jvi.asm.org/cgi/content/abstract/JVI.00134-10v1
Host range and cellular tropism of the human exogenous gammaretrovirus XMRV.
Stieler K, Schulz C, Lavanya M, Aepfelbacher M, Stocking C, Fischer N.
2010 Mar 30
Virology
http://www.sciencedirect.com/science/article/pii/S0042682209008137
Raltegravir Is a Potent Inhibitor of XMRV, a Virus Implicated in Prostate Cancer and Chronic Fatigue Syndrome
Ila R. Singh, John E. Gorzynski, Daria Drobysheva, Leda Bassit, Raymond F. Schinazi
April 1, 2010
PLoS ONE
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009948
Evaluation of Cellular Determinants Required for In Vitro Xenotropic Murine Leukemia Virus-Related Virus Entry into Human Prostate Cancer and Noncancerous Cells
Sushma Bhosle, Suganthi Suppiah, Ross Molinaro, Yuying Liang, Rebecca Arnold, William Diehl, Natalia Makarova, Jerry Blackwell, John Petros, Dennis Liotta, Eric Hunter, and Hinh Ly
21 April 2010
Journal of Virology
http://jvi.asm.org/cgi/content/full...ld&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT
Prostate Cancer and Noncancerous Cells
Sushma Bhosle, Suganthi Suppiah, Ross Molinaro, Yuying Liang, Rebecca Arnold, William Diehl, Natalia Makarova, Jerry Blackwell, John Petros, Dennis Liotta, Eric Hunter, and Hinh Ly
21 April 2010
Journal of Virology
http://jvi.asm.org/cgi/content/full...ld&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT
Repeated Detection of Infectious Xenotropic Murine Virus-Related Virus (XMRV) in Human Neoplasia and Neuroimmune Diseases
Francis Ruscetti, Vincent Lombardi, Max Pfost, Kathryn Hagen, Judy Mikovits
26-27 April 2010
Unpublished - Presented at the 12th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI)
http://oham.cancer.gov/objects/pdf/2010ICMAOI_Program_Book.pdf
Characterization of retroviral and lentiviral vectors pseudotyped with xenotropic murine leukemia virus-related virus envelope glycoprotein
Sakuma T, De Ravin SS, Tonne JM, Thatava T, Ohmine S, Takeuchi Y, Malech HL, Ikeda Y.
May 27, 2010
Human Gene Therapy
http://www.liebertonline.com/doi/abs/10.1089/hum.2010.063
Apobec 3G Efficiently Reduces Infectivity of the Human Exogenous Gammaretrovirus XMRV
Kristin Stieler, Nicole Fischer
July 23, 2010
PLoS ONE
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0011738
Acutely transforming retrovirus expressing Nras generated from HT-1080 fibrosarcoma cells infected with the human retrovirus XMRV
Metzger MJ, Miller AD.
August 2010
Journal of Virology
http://jvi.asm.org/cgi/content/full/84/15/7908?view=long&pmid=20504941
Characterization of antibodies elicited by XMRV infection and development of immunoassays useful for epidemiologic studies
Xiaoxing Qiu, Priscilla Swanson, Ka-Cheung Luk, Bailin Tu, Francois Villinger, Jaydip Das Gupta, Robert H Silverman, Eric A Klein, Sushil Devare, Gerald Schochetman, John Hackett Jr
17 August 2010
Retrovirology 2010
http://www.retrovirology.com/content/pdf/1742-4690-7-68.pdf
Evolution of Functional and Sequence Variants of the Mammalian XPR1 Receptor for Mouse Xenotropic Gammaretroviruses and the Human-Derived Retrovirus XMRV
Yuhe Yan, Qingping Liu, Kurt Wollenberg, Carrie Martin, Alicia Buckler-White, and Christine A. Kozak
1 September 2010
Journal of Virology, Nov. 2010
http://jvi.asm.org/cgi/reprint/84/22/11970
Common Inbred Strains of the Laboratory Mouse That Are Susceptible to Infection by Mouse Xenotropic Gammaretroviruses and the Human-Derived Retrovirus XMRV
Surendranath Baliji, Qingping Liu,, and Christine A. Kozak
December 2010
Journal of Virology
http://jvi.asm.org/cgi/content/full/84/24/12841?view=long&pmid=20943975
Characterization of retroviral and lentiviral vectors pseudotyped with xenotropic murine leukemia virus-related virus envelope glycoprotein
Sakuma T, De Ravin SS, Tonne JM, Thatava T, Ohmine S, Takeuchi Y, Malech HL, Ikeda Y.
December 10, 2010
Human Gene Therapy
http://www.liebertonline.com/doi/abs/10.1089/hum.2010.063
Severe Restriction of Xenotropic Murine Leukemia Virus-Related Virus Replication and Spread in Cultured Human Peripheral Blood Mononuclear Cells
Chawaree Chaipan, Kari A. Dilley, Tobias Paprotka, Krista A. Delviks-Frankenberry, Narasimhan J. Venkatachari, Wei-Shau Hu, and Vinay K. Pathak*
2011 J. Virol. doi:10.1128/JVI.00046-11
Journal of Virology
http://jvi.asm.org/cgi/content/abstract/JVI.00046-11v1
Infection, viral dissemination and antibody responses of Rhesus macaques exposed to the human gammaretrovirus XMRV
Nattawat Onlamoon, Jaydip Das Gupta, Prachi Sharma, Kenneth Rogers, Suganthi Suppiah, Jeanne Rhea, Ross J. Molinaro, Christina Gaughan, Beihua Dong, Eric A. Klein, Xiaoxing Qiu, Sushil Devare, Gerald Schochetman, John Hackett Jr., Robert H Silverman, and Franois Villinger
2011 J. Virol. doi:10.1128/JVI.02411-10
http://jvi.asm.org/cgi/content/abstract/JVI.02411-10v1
NF-kB Activation Stimulates Transcription and Replication of Retrovirus XMRV in Human B-Lineage and Prostate Carcinoma Cells
Shuhei Sakakibara, Kaori Sakakibara,, and Giovanna Tosato
26 January 2011
Journal of Virology, April 2011, p. 3179-3186, Vol. 85, No. 7
http://jvi.asm.org/cgi/content/short/85/7/3179
Human APOBEC3 proteins can inhibit xenotropic murine leukemia virus-related virus infectivity
Hal P. Bogerd, Fengwen Zhang, Paul D. Bieniasz and Bryan R. Cullen
5 February 2011
Virology
http://www.sciencedirect.com/science/article/pii/S0042682210007270
Purify First: Rapid expression and purification of proteins from XMRV
William K. Gillette, Dominic Esposito, Troy E. Taylor, Ralph F. Hopkins, Rachel K. Bagni and James L. Hartley
April 2011
Protein Expression and Purification
http://www.sciencedirect.com/science/article/pii/S1046592810003414
Xmrv Infection Induces Host Genes That Regulate Inflammation And Cellular Physiology
Michael Lee, Elona Gusho, Jaydip Das Gupta, Eric Klein, Robert Silverman
April 2011
The Journal of Urology
(Unpublished abstract - presented at the American Urological Association meeting)
http://www.jurology.com/article/S0022-5347(11)00620-3/fulltext
Antibody Responses against Xenotropic Murine Leukemia Virus-Related Virus Envelope in a Murine Model
Natalia Makarova, Chunxia Zhao, Yuanyuan Zhang, Sushma Bhosle, Suganthi Suppiah, Jeanne M. Rhea, Natalia Kozyr, Rebecca S. Arnold, Hinh Ly, Ross J. Molinaro, Tristram G. Parslow, Eric Hunter, Dennis Liotta, John Petros, Jerry L. Blackwell
April 6, 2011
PLoS ONE
http://www.plosone.org/article/info...onid=159E155669BA4FC9765C02D8E1CDCFD3.ambra01
Xenotropic Murine Leukemia Virus-related Virus-associated Chronic Fatigue Syndrome Reveals a Distinct Inflammatory Signature
VINCENT C LOMBARDI, KATHRYN S HAGEN, KENNETH W HUNTER, JOHN W DIAMOND, JULIE SMITH-GAGEN, WEI YANG, and JUDY A. MIKOVITS
May-June 2011
in vivo 25: 307-314 (2011
http://iv.iiarjournals.org/content/25/3/307.abstract?etoc
Sexual transmission of XMRV:a potential infection route
Prachi Sharma, Kenneth Rogers, Suganthi Suppiah, Ross Ross Molinaro Ross J. Molinaro, Nattawat Onlamoon, J. Hackett Jr., G. Schochetman, Eric A. Klein, Robert Silverman, and F. Villinger
25 May 2011
Advances in Virology
http://www.hindawi.com/journals/av/aip/965689/
Naturally occurring polymorphisms of the mouse gammaretrovirus receptors CAT-1 and XPR1 alter virus tropism and pathogenicity
Christine A. Kozak
12 July 2011
Advances in Virology
http://www.hindawi.com/journals/av/aip/975801/
Frequent detection of infectious xenotropic murine leukemia virus (XMLV) in human cultures established from mouse xenografts
Yu-An Zhang, Anirban Maitra, Jer-Tsong Hsieh, Charles M. Rudin, Craig Peacock, Collins Karikari, Rolf A. Brekken, Victor Stastny, Boning Gao, Luc Girard, Ignacio Wistuba, Eugene Frenkel, John D. Minna and Adi F. Gazdar
October 1, 2011
Cancer Biology & Therapy Volume 12, Issue 7
https://www.landesbioscience.com/journals/5/article/15955/
https://www.landesbioscience.com/journals/cbt/ZhangCBT12-7.pdf
XMRV & CFS Patients - Published negative studies
Failure to Detect the Novel Retrovirus XMRV in Chronic Fatigue Syndrome
Otto Erlwein, Steve Kaye, Myra O. McClure, Jonathan Weber, Gillian Wills, David Collier, Simon Wessely, Anthony Cleare
January 6, 2010
PloS One
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0008519
Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome
Harriet CT Groom, Virginie C Boucherit, Kerry Makinson, Edward Randal, Sarah Baptista, Suzanne Hagan, John W Gow, Frank M Mattes, Judith Breuer, Jonathan R Kerr, Jonathan P Stoye, Kate N Bishop
15 February 2010
Retrovirology
http://www.retrovirology.com/content/7/1/10
Prevalence of xenotropic murine leukaemia virus-related virus in patients with chronic fatigue syndrome in the Netherlands: retrospective analysis of samples from an established cohort
Frank J M van Kuppeveld, Arjan S de Jong, Kjerstin H Lanke, Gerald W Verhaegh, Willem J G Melchers, Caroline M A Swanink, Gijs Bleijenberg, Mihai G Netea, Jochem M D Galama, Jos W M van der Meer
25 February 2010
BMJ
http://www.bmj.com/content/340/bmj.c1018.full
Absence of evidence of Xenotropic Murine Leukemia Virus-related virus infection in persons with Chronic Fatigue Syndrome and healthy controls in the United States
William M Switzer, Hongwei Jia, Oliver Hohn, HaoQiang Zheng, Shaohua Tang, Anupama Shankar, Norbert Bannert, Graham Simmons, R Michael Hendry, Virginia R Falkenberg, William C Reeves and Walid Heneine
1 July 2010
Retrovirology
http://www.retrovirology.com/content/7/1/57
Failure to detect Xenotropic murine leukaemia virus-related virus in Chinese patients with chronic fatigue syndrome
Ping Hong, Jinming Li, Yongzhe Li
13 September 2010
Virology Journal
http://www.virologyj.com/content/pdf/1743-422x-7-224.pdf
Xenotropic murine leukemia virus-related virus prevalence in patients with chronic fatigue syndrome or chronic immunomodulatory conditions
Henrich TJ, Li JZ, Felsenstein D, Kotton CN, Plenge RM, Pereyra F, Marty FM, Lin NH, Grazioso P, Crochiere DM, Eggers D, Kuritzkes DR, Tsibris AM.
2010 Nov 15
The Journal of Infectious Diseases
http://www.ncbi.nlm.nih.gov/pubmed/20936980
No Evidence for XMRV in German CFS and MS Patients with Fatigue Despite the Ability of the Virus to Infect Human Blood Cells In Vitro
Oliver Hohn, Kristin Strohschein, Alexander U. Brandt, Sandra Seeher, Sandra Klein, Reinhard Kurth, Friedemann Paul, Christian Meisel, Carmen Scheibenbogen, Norbert Bannert
December 22, 2010
PLoS ONE
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015632
Serologic and PCR testing of persons with chronic fatigue syndrome in the United States shows no association with xenotropic or polytropic murine leukemia virus-related viruses
Brent C Satterfield, Rebecca A Garcia, Hongwei Jia, Shaohua Tang, HaoQiang Zheng, and William M Switzer
22 February 2011
Retrovirology
http://www.retrovirology.com/content/8/1/12
Investigation into the Presence of and Serological Response to XMRV in CFS Patients
Otto Erlwein, Mark J. Robinson, Steve Kaye, Gillian Wills, Shozo Izui, Simon Wessely, Jonathan Weber, Anthony Cleare, David Collier, Myra O. McClure
March 9, 2011
PLoS ONE
http://www.plosone.org/article/info...onid=D53FC24B8C7988B2019B952378A8CB06.ambra02
No association of xenotropic murine leukemia virus-related virus with prostate cancer or chronic fatigue syndrome in Japan
Rika A Furuta, Takayuki Miyazawa, Takeki Sugiyama, Hirohiko Kuratsune, Yasuhiro Ikeda, Eiji Sato, Naoko Misawa, Yasuhito Nakatomi, Ryuta Sakuma, Kazuta Yasui, Kouzi Yamaguti, and Fumiya Hirayama
17 March 2011
Retrovirology
http://www.retrovirology.com/content/8/1/20
Analysis of cerebrospinal fluid from chronic fatigue syndrome patients for multiple human ubiquitous viruses and xenotropic murine leukemia-related virus
Steven E Schutzer MD, Megan A Rounds M, Benjamin H Natelson MD, David J Ecker PhD, Mark W Eshoo PhD
6 April 2011
Annals of Neurology
http://onlinelibrary.wiley.com/doi/10.1002/ana.22389/abstract
Absence of XMRV and other MLV-related viruses in patients with Chronic Fatigue Syndrome
Clifford H. Shin, Lucinda Bateman, Robert Schlaberg, Ashley M. Bunker, Christopher J. Leonard, Ronald W. Hughen, Alan R. Light, Kathleen C. Light, and Ila R. Singh
4 May 2011
Journal of Virology
http://jvi.asm.org/cgi/content/abstract/JVI.00693-11v1
No Evidence of Murine-Like Gammaretroviruses in CFS Patients Previously
Identified as XMRV-Infected
Konstance Knox, Donald Carrigan, Graham Simmons, Fernando Teque,Yanchen Zhou, John Hackett Jr.,Xiaoxing Qiu, Ka-Cheung Luk, Gerald Schochetman, Allyn Knox, Andreas M. Kogelnik, Jay A. Levy
31 May 2011
Sciencexpress
http://www.sciencemag.org/content/early/2011/05/31/science.1204963.full.pdf
Failure to detect XMRV-specific antibodies in the plasma of CFS patients using Highly Sensitive Chemiluminescence Immunoassays
Brendan Oakes, Xiaoxing Qiu, Susan Levine, J. Hackett Jr., and Brigitte Huber
10 June 2011
Advances in Virology
http://www.hindawi.com/journals/av/aip/854540/
Xenotropic murine leukemia virus-related virus in monozygotic twins discordant for chronic fatigue syndrome
Jerome KR, Diem K, Huang ML, Selke S, Corey L, Buchwald D.
Diagnostic Microbiology and Infectious Disease
doi:10.1016/j.diagmicrobio.2011.06.003
26 July 2011
http://www.ncbi.nlm.nih.gov/pubmed/21795004
Inconclusive studies & studies that add some knowledge about XMRV
No Association of Xenotropic Murine Leukemia Virus-Related Viruses with Prostate Cancer
William M. Switzer, Hongwei Jia, HaoQiang Zheng, Shaohua Tang, Walid Heneine
May 4, 2011
PLoS ONE
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0019065#abstract0
("Also, the finding of a viral strain in three prostate cancer patients that is distinct from the XMRV seen in previous studies is significant and demonstrates a broader viral diversity. This would be an expected result consistent with virus evolution during spread and persistence.")
Overviews of XMRV Research
A Scientific Journey Through the 2-5A/RNase L System
Robert H. Silverman
2007
Cytokine Growth Factor Rev. 2007
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075094/pdf/nihms30420.pdf
http://www.ncbi.nlm.nih.gov/pubmed/17681844
Implications for XMRV Infections In Prostate Cancer
Seunghee Hong
January, 2010
Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy
Department of Molecular Biology and Microbiology
Molecular Virology Program
Case Western Reserve University
http://etd.ohiolink.edu/send-pdf.cgi/Hong Seunghee.pdf?case1251739728
The human retrovirus XMRV in prostate cancer and chronic fatigue syndrome
Robert H. Silverman, Carvell Nguyen, Christopher J. Weight & Eric A. Klein
1 June 2010
Nature Reviews Urology
http://www.nature.com/nrurol/journal/v7/n7/abs/nrurol.2010.77.html
Biology and pathophysiology of the new human retrovirus XMRV and its association with human disease
Alice Rusmevichientong and Samson A. Chow
August 18, 2010
Immunological Research
http://www.springerlink.com/content/w07qx0236q801q39/
The mouse xenotropic gammaretroviruses and their XPR1 receptor
Christine A Kozak
30 November 2010
Retrovirology 2010
http://www.retrovirology.com/content/pdf/1742-4690-7-101.pdf
Of mice and men: on the origin of XMRV (Article)
Antoinette Cornelia van der Kuyl, Marion Cornelissen and Ben Berkhout
17 January 2011
Frontier in Virology
http://www.frontiersin.org/virology/10.3389/fmicb.2010.00147/full
XMRV Discovery and Prostate Cancer Related Research
David Kang, Michael Lee, Jaydip Das Gupta, Eric A. Klein, and R. H. Silverman
25 May 2011
Advances in Virology
http://www.hindawi.com/journals/av/aip/432837/
http://downloads.mts.hindawi.com/MTS-Files/AV/papers/XMLV/432837.v2.pdf
Human infection or lab artifact: will the real XMRV please stand up? (Abstract only)
Silverman
6 June 2011
Presentation from the "15th International Conference on Human Retroviruses: HTLV and Related Viruses"
http://www.retrovirology.com/content/8/S1/A241
http://www.retrovirology.com/content/pdf/1742-4690-8-S1-A241.pdf
Testing Strategies for Detection of Xenotropic Murine Leukemia Virus Related Virus (XMRV) Infection
Shixing Tang and Indira K. Hewlett
10 June 2011
Advances in Virology
http://www.hindawi.com/journals/av/aip/281425/
Phylogeny-directed search for murine leukemia virus - like retroviruses in vertebrate genomes, and in patients suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Prostate Cancer
J. Blomberg, Ali Sheikholvaezin, Amal Elfaitouri, Fredrik Blomberg, Anna Sjsten, Johan Mattson Ulfstedt, Rudiger Pipkorn, Klas Kllander, Christina hrmalm, and Gran Sperber.
22 June 2011
Advances in Virology
http://www.hindawi.com/journals/av/aip/341294/
Reviews
Distribution of Xenotropic Murine Leukemia Virus-Related Virus (XMRV) Infection in Chronic Fatigue Syndrome and Prostate Cancer
Judy A.Mikovits, Ying Huang, Max A.Pfost, Vincent C.Lombardi, Daniel C.Bertolette, Kathryn S.Hagen, and Francis W.Ruscetti.
2010
AIDS Review
http://www.aidsreviews.com/files/2010_12_3_149-152.pdf
Detecting Retroviral Sequences in Chronic Fatigue Syndrome
Ila R. Singh
3 November 2010
Viruses 2010
http://www.mdpi.com/1999-4915/2/11/2404/pdf
Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples
J. M. Coffin and Oya Cingz
Advances in Virology
7 July 2011
http://www.hindawi.com/journals/av/aip/940210/
Letters to Scientific Journals
Mouse viruses and human disease (Letter)
Gkikas Magiorkinis
April 2011 doi:10.1016/S1473-3099(11)70081-0
The Lancet Infectious Diseases
http://www.thelancet.com/journals/l...lsca1=TLID-290311&elsca2=email&elsca3=segment
Mouse viruses and human disease (Letter)
Alexandre FR Stewart, D William Cameron
April 2011 doi:10.1016/S1473-3099(11)70082-2
The Lancet Infectious Diseases
http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(11)70082-2/fulltext
Blood Related Studies & Reviews
Xenotropic murine leukemia virusrelated virus (XMRV) and blood transfusion: report of the AABB interorganizational XMRV task force
Harvey G. Klein, Roger Y. Dodd, F. Blaine Hollinger, Louis M. Katz, Steven Kleinman,
K. Kimberly McCleary, Robert H. Silverman, and Susan L. Stramer
- for the AABB Interorganizational Task Force on XMRV
51, March 2011
Transfusion
http://www.aabb.org/pressroom/Documents/xmrvcommrpt011811.pdf
The Blood Xenotropic Murine Leukemia VirusRelated Virus Scientific Research Working Group: mission, progress, and plans
Graham Simmons, Simone A. Glynn, Jerry A. Holmberg, John M. Coffin, Indira K. Hewlett, Shyh-Ching Lo, Judy A. Mikovits, William M. Switzer, Jeffrey M. Linnen, Michael P. Busch
- for the Blood XMRV Scientific Research Working Group
1 March 2011
Transfusion
http://onlinelibrary.wiley.com/doi/10.1111/j.1537-2995.2011.03063.x/abstract
XMRV, Q fever and other emerging infections: impact on management of blood safety
R. Y. Dodd
2011
2011 International Society of Blood Transfusion,
ISBT Science Series (2011) 6, 11912
http://onlinelibrary.wiley.com/doi/10.1111/j.1751-2824.2011.01454.x/pdf
AABB XMRV information sheet:
http://www.aabb.org/resources/bct/eid/Documents/xmrvfactsheet.pdf
PCR Master Mixes Harbour Murine DNA Sequences. Caveat Emptor!
Philip W. Tuke, Kate I. Tettmar, Asif Tamuri, Jonathan P. Stoye, Richard S. Tedder.
May 25, 2011
PLoS ONE
http://www.plosone.org/article/fetc...icleURI=info:doi/10.1371/journal.pone.0019953
No Evidence of XMRV or MuLV Sequences in Prostate Cancer, Diffuse Large B-Cell Lymphoma, or the UK Blood Donor Population
Mark James Robinson, Philip William Tuke, Otto Erlwein, Kate I. Tettmar, Steve Kaye, Kikkeri N. Naresh, Anup Patel, Marjorie M. Walker, Takahiro Kimura, Ganesh Gopalakrishnan, Richard S. Tedder, and Myra O. McClure
31 March 2011
Advances in Virology doi:10.1155/2012/782353
http://www.hindawi.com/journals/av/2011/782353/
Patents applied for
Compositions And Methods Relating To Xmrv-Related Diseases And Conditions
Singh, Ila Ramnaresh; (US). Thaker, Harshwardhan Manohar; (US). Schlaberg, Robert; (US). Shin, Clifford; (US)
The University Of Utah Research Foundation
(XMRV in breast cancer)
Patent:
http://www.wipo.int/patentscope/search/en/WO2010132886
Info:
http://www.facebook.com/notes/xmrv-...s-on-xmrv-breast-cancer-prostate/472237776796
Diagnosis And Treatment Of Diseases Or Disorders Associated With Xenotropic Murine Leukemia Virus-Related Virus
MIKOVITS, Judy, A.; (US). LOMBARDI, Vincent, C.; (US). RUSCETTI, Sandra, K.; (US). RUSCETTI, Francis, W.; (US)
WPI
Methods of detecting XMRV, and diagnosing XMRV-related illnesses etc.
http://www.wipo.int/patentscope/sea...lter=&sortOption=&queryString=&tab=PCT+Biblio
Detection Of Xenotropic Murine Leukemia Virus
Mikovits; Judy A.; (Reno, NV) ; Lombardi; Vincent; (Reno, NV) ; Ruscetti; Sandra; (New Market, MD) ; Ruscetti; Francis; (New Market, MD) ; Silverman; Robert; (Beachwood, OH)
WPI
"Methods of detecting, diagnosing, monitoring or managing an XMRV-related neuroimmune disease such as chronic fatigue syndrome or XMRV-related lymphoma such as mantle cell lymphoma in a subject are disclosed."
June 23, 2011
http://www.freepatentsonline.com/y2011/0151431.html
http://appft.uspto.gov/netacgi/nph-...ND&d=PG01&s1=mikovits&OS=mikovits&RS=mikovits
Positive XMRV Prostate Cancer studies
Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant.
Urisman A, Molinaro RJ, Fischer N, Plummer SJ, Casey G, Klein EA, Malathi K, Magi-Galluzzi C, Tubbs RR, Ganem D, Silverman RH, DeRisi JL.
31st March 2006
http://www.ncbi.nlm.nih.gov/pubmed/16609730?dopt=Abstract&holding=f1000,f1000m,isrctn
(XMRV was first discovered in 2006 in prostate cancer patients. This is the original XMRV paper)
(Results: XMRV in QQ genotype = 40%, XMRV in RQ + RR genotypes = 1.5%, Healthy controls = not tested.)
XMRV is present in malignant prostatic epithelium and is associated with prostate cancer, especially high-grade tumors
Robert Schlaberga, Daniel J. Choeb, Kristy R. Browna, Harshwardhan M. Thakerb and Ila R. Singh,
September 8, 2009
PNAS
http://www.pnas.org/content/early/2009/09/04/0906922106.abstract
(Results: XMRV in prostate cancer tissue by IHC = 23%. XMRV in benign tissue controls by IHC = 4%)
XMRV infection in patients with prostate cancer: novel serologic assay and correlation with PCR and FISH.
Arnold RS, Makarova NV, Osunkoya AO, Suppiah S, Scott TA, Johnson NA, Bhosle SM, Liotta D, Hunter E, Marshall FF, Ly H, Molinaro RJ, Blackwell JL, Petros JA.
April 2010
Urology
http://www.goldjournal.net/article/S0090-4295(10)00117-2/abstract
(Results: XMRV in QQ genotype tested for XMRV antibodies = 40%, XMRV in either RQ or RR genotype = 15%, Healthy controls = not tested.)
Detection of xenotropic murine leukemia virus-related virus in normal and tumor tissue of patients from the southern United States with prostate cancer is dependent on specific polymerase chain reaction conditions
Danielson BP, Ayala GE, Kimata JT.
Nov 2010.
The Journal of Infection Diseases
http://www.ncbi.nlm.nih.gov/pubmed/20936978
(Results: XMRV detected in 22% of prostate cancer patients, in normal and tumour prostate tissue, independent of genotype. Healthy controls not tested.)
Unpublished Positive XMRV Prostate Cancer studies
Xenotropic Murine Leukemia Virus Related Virus (Xmrv) Is Present In Malignant Prostate Tissue But Does Not Affect Pathological Or Clinical Outcome
Chad Ritch, Ruslan Korets, Mireia Castillo-Martin, Josep Domingo-Domenech, Mitchell Benson, Carlos Cordon-Cardo
April 2011
The Journal of Urology (Abstract presented at the American Urological Association meeting)
http://www.jurology.com/article/S0022-5347(11)01618-1/fulltext
Immunofluorescence: XMRV detected in 33/65 (51%) of malignant samples, and in only 5/42 benign samples (12%).
PCR: XMRV detected 14/65 (21%) of prostate cancer samples, and 2/42 (5%) in benign tissue
Combined PCR and IF: XMRV was detected in at least 17% of malignant samples and rarely found in benign tissue.
A Preliminary Screening Of Xenotropic Murine Leukemia Virus-Related Virus In Japanese Prostate Cancer Patients
Tsukasa Igawa, Yoshinao Kubo, Katsura Kakoki, Naoki Yamamoto, Hideki Sakai
April 2011
The Journal of Urology (Abstract presented at the American Urological Association meeting)
http://www.jurology.com/article/S0022-5347(11)01208-0/fulltext
(MLV sequences were detected in four out of sixty one patients (6.7%))
Inconclusive & No Association XMRV Prostate Cancer studies (Some XMRV detected)
Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer.
Fischer N, Hellwinkel O, Schulz C, Chun FK, Huland H, Aepfelbacher M, Schlomm T.
2008 Nov (published online 29 September 2008)
J Clin Virol. 2008 Nov;43(3):277-83. Epub 2008 Sep 27.
http://www.journalofclinicalvirology.com/article/S1386-6532(08)00301-6/abstract
(Results: XMRV in prostate cancer = 0.95% XMRV in healthy controls = 1.4%)
Identification of viral infections in the prostate and evaluation of their association with cancer
Martinez-Fierro ML, Leach RJ, Gomez-Guerra LS, Garza-Guajardo R, Johnson-Pais T, Beuten J, Morales-Rodriguez IB, Hernandez-Ordoez MA, Calderon-Cardenas G, Ortiz-Lopez R, Rivas-Estilla AM, Ancer-Rodriguez J, Rojas-Martinez A.
24 June 2010
BMC Cancer
http://www.biomedcentral.com/1471-2407/10/326/
(Results: XMRV in prostate cancer tissue=0. XMRV in normal controls = 1.3%)
Prevalence of human xenotropic murine leukemia virus-related gammaretrovirus (XMRV) in Dutch prostate cancer patients.
Verhaegh GW, de Jong AS, Smit FP, Jannink SA, Melchers WJ, Schalken JA.
March 2011
http://www.ncbi.nlm.nih.gov/pubmed/20878949
(Results: XMRV sequences were detected in 3 out of 74 (i.e., 4%) PrCa specimens.)
No association of xenotropic murine leukemia virus-related virus with prostate cancer or chronic fatigue syndrome in Japan
Furuta RA, Miyazawa T, Sugiyama T, Kuratsune H, Ikeda Y, Sato E, Misawa N, Nakatomi Y, Sakuma R, Yasui K, Yamaguti K, Hirayama F.
17th March 2011
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065418/
No evidence of XMRV in prostate cancer cohorts in the Midwestern United States
Toshie Sakuma, Stphane Hu , Karen A Squillace , Jason M Tonne , Patrick R Blackburn , Seiga Ohmine , Tayaramma Thatava , Greg J Towers and Yasuhiro Ikeda.
29 March 2011
Retrovirology 2011, 8:23doi:10.1186/1742-4690-8-23
http://www.retrovirology.com/content/8/1/23
No Association of Xenotropic Murine Leukemia Virus-Related Viruses with Prostate Cancer
William M. Switzer, Hongwei Jia, HaoQiang Zheng, Shaohua Tang, Walid Heneine
May 4, 2011
PLoS ONE
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0019065#abstract0
(Results: XMRV in prostate cancer = 1.9%)
continued in next post.....
