I have not tried. Generally, the rationale I propose for use of interferon suppositories is detailed in this post. I think that technique could keep ME/CFS patients in remission. Interferon therapy results in dramatic improvements in around half of all enterovirus ME/CFS patients who try it. But they relapse some months later. So my idea is after interferon therapy, you then take daily interferon suppositories as a maintenance dose, to prevent relapse.