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Copy of tweets from Clevland Clinic, Start reading from the bottoms first.
9/08
John Coffin: "Until we have a good way to assess the virus, it's premature." #xmrv #mecfs
Wed Sep 08 2010 18:03:30
Q: When are we going to try drugs therapies? #xmrv #mecfs
Wed Sep 08 2010 17:52:44
Jonathan Stoye: "There will be defined assays in a short period of time, around the nucleus of the Blood Working Group." #xmrv #mecfs
Wed Sep 08 2010 17:45:44
The lack of a standard is a theme of the past few days. The Blood Working Group is working to achieve this. #xmrv #mecfs
Wed Sep 08 2010 17:36:21
Question: What are the plans for ensuring researchers test the same ways? #xmrv #mecfs
Wed Sep 08 2010 17:34:30
@bob_cowjuice don't have them, but seems they will be published when the researchers submit the paper shortly.
Wed Sep 08 2010 17:21:47 in reply to bob_cowjuice
@Shhh528 They are reporting the assays used. There have been many and they are not household terms.
Wed Sep 08 2010 17:19:48 in reply to Shhh528
Q&A panel members are Donald Blair, NCI-NIH; John Coffin, Tufts; Jerry Holmberg; US HHS Judy Mikovits, WPI #XMRV #MECFS
Wed Sep 08 2010 17:07:07
Wrap-up Q&A session 5:15 p.m. ET. Webcast:
http://ow.ly/2BohM #XMRV #MECFS
Wed Sep 08 2010 17:06:20
Jonas Blomberg from Uppsala University: No evidence for MLV-related viruses in Sweden. #XMRV #MECFS
Wed Sep 08 2010 17:03:04
Bannert: None of the 36 CFS patients or 27 healthy controls tested positive for XMRV. #XMRV #MECFS
Wed Sep 08 2010 16:48:11
Norbert Bannert from Robert Koch-Institut: Based on his sequencing, he could not find XMRV in CFS or ME patients in Germany. #XMRV #MECFS
Wed Sep 08 2010 16:45:29
Kearney: It detects XMRV with great sensitivity & distinguishes background mouse DNA contamination "with 100% accuracy.” #XMRV #MECFS
Wed Sep 08 2010 16:18:21
Mary Kearney from NCI/NIH discussing an assay they've developed and tested. #XMRV #MECFS
Wed Sep 08 2010 16:17:03
Mikovits says her research on UK patients was just unblinded & she’s working on a manuscript for publication w/more details #XMRV #MECFS
Wed Sep 08 2010 14:42:25
More Mikovits: she’s confirmed #XMRV in CFS patients in UK population (previous studies didn’t find the retrovirus in UK patients) #MECFS
Wed Sep 08 2010 14:40:55
Mikovits: "We know this is a hormone-related virus, that's why we see it in younger patients [around puberty]." #XMRV #MECFS
Wed Sep 08 2010 13:14:01
Judy Mikovits of Whittemore Peterson Institute calling this HMRV (Human MLV-Related Viruses) to describe this class of viruses #XMRV #MECFS
Wed Sep 08 2010 13:13:13
Dr. Lo: “All I can say is that we detected it on the first PCR (polymerase chain reaction)." #XMRV #MECFS
Wed Sep 08 2010 13:07:36
Dr. Shyh-Ching Lo from FDA: “Several conditions make the difference in being able to detect the virus in samples.” #XMRV #MECFS
Wed Sep 08 2010 13:06:46
Audience members commenting that the samples in this study involved heperinized blocks; it would impact the ability to detect. #XMRV #MECFS
Wed Sep 08 2010 12:41:43
Huber: "When we sequenced this sample, it was a false positive. In this one cohort, we cannot see XMRV."
Wed Sep 08 2010 12:40:28
Huber: "Out of 111 patients (selected based on CDC criteria), one of the samples was positive for XMRV."
Wed Sep 08 2010 12:40:11
Huber: When we tested our samples, we found a shocking correlation: no CFS samples were XMRV positive &also negative for the 2 mouse probes.
Wed Sep 08 2010 12:39:37
Huber: "We felt compelled to test for mouse contamination. We used a mitochondrial assay to detect mouse DNA."
Wed Sep 08 2010 12:38:29
This time, 2/3 CFS patients were positive, healthy controls had 17/36 positive. Most samples contained multiple viruses. #XMRV #MECFS
Wed Sep 08 2010 12:36:57
Huber: All samples were processed in our lab with a new isolation protocol. #XMRV #MECFS
Wed Sep 08 2010 12:35:53
Last fall, she started to collect new samples, taken in 2009. It’s very few samples (3 CFS and 36 healthy controls). #XMRV #MECFS
Wed Sep 08 2010 12:35:22
Her first cohort, all samples were negative. Her second test found 1 out of 111 samples were positive, using different assays. #XMRV #MECFS
Wed Sep 08 2010 12:34:39
Brigitte Huber of Tufts – her patient samples were taken in 2005 and selected based on the Fukuda/CDC criteria. #XMRV #MECFS
Wed Sep 08 2010 12:33:50
Ruscetti: “This is the last talk I'm going to give on detection. I'm now going to work on pathogenesis." #XMRV #CFS
Wed Sep 08 2010 12:17:40
Ruscetti: "XMRV research is in its infancy; there is no evidence yet for pathogenesis.” #XMRV #CFS
Wed Sep 08 2010 12:16:23
Dr. Frank Ruscetti from NCI: "We identified both polytropic MLV and XMRV in some CFS patient samples."
Wed Sep 08 2010 12:14:51
‘World Class Virus Hunter’ To Head Up the Latest XMRV Study - Health Blog - WSJ
http://ow.ly/2B8lI #XMRV #MECFS
Wed Sep 08 2010 10:38:05
CFS Central's blog entry on the first day of the #XMRV workshop
http://ow.ly/2B8jA
Wed Sep 08 2010 10:29:04
Singh taking measures to avoid contamination & ensure consistency; handle only 1 patient sample at a time to avoid contamination #XMRV #CFS
Wed Sep 08 2010 09:40:50
Patient & control samples are processed in identical manner; all samples freshly collected. Other studies haven't done so. #XMRV #CFS
Wed Sep 08 2010 09:38:33
Both patients & controls in Singh's study are from the same geographic area -- will help find minor variations in the virus. #XMRV #CFS
Wed Sep 08 2010 09:37:09
Singh is doing a study w/200 healthy volunteers and 105 #CFS patients. #XMRV
Wed Sep 08 2010 09:36:00
Singh found it interesting that one fourth of #CFS cases from Nevada developed a lymphoma. #XMRV
Wed Sep 08 2010 09:34:22
The amount of #XMRV infection in the prostate can vary based on how deep you look at the tumor tissue, Singh says
Wed Sep 08 2010 09:33:19
Singh: 27% of prostate cancers have XMRV; the higher the Gleason score, the higher the likelihood of finding #XMRV
Wed Sep 08 2010 09:32:28
Singh's lab started studying #XMRV after @ClevelandClinic discovery
Wed Sep 08 2010 09:31:08
Up next at #XMRV workshop: Dr. Ila Singh, Associate Professor, Department of Pathology, University of Utah to address prostate cancer & #CFS
Wed Sep 08 2010 09:30:05
that is noninvasive, rapid, and easy to perform, avoiding the difficulty of obtaining blood or tissue biopsies. #XMRV
Wed Sep 08 2010 09:14:29
Klein: The presence of XMRV RNA in urine is significant because such data can provide the basis for a urine-based #XMRV detection assay …
Wed Sep 08 2010 09:13:52
There is a strong likelihood that there is a family of #XMRV viruses
Wed Sep 08 2010 08:57:02
The technique you use to find #XMRV largely impacts your ability to detect it, thus why there have been conflicting studies, Klein says
Wed Sep 08 2010 08:55:51
Klein: We no longer believe that #XMRV only infects men
Wed Sep 08 2010 08:54:37
Klein: It’s not out of the realm of possibility that prostate cancer could be an infectious disease #XMRV
Wed Sep 08 2010 08:46:53
An estimated 20% of all cancers worldwide are caused by infectious agents & it’s not unlikely that prostate cancer could be as well #XMRV
Wed Sep 08 2010 08:45:14
We need to be able to sort out aggressive vs. non-aggressive prostate cancer, and #XMRV potentially could help do that, Klein says
Wed Sep 08 2010 08:44:08
About 90% of men choose to be treated for prostate cancer, but all therapies have significant side effects, Klein says #XMRV
Wed Sep 08 2010 08:43:42
Klein: Clinicians face the challenge of trying to identify aggressive prostate cancer versus non-aggressive #XMRV
Wed Sep 08 2010 08:42:02
Dr. Eric Klein, chairman of Cleveland Clinic’s urological institute, presenting data on detection of #XMRV in prostatic secretions.
Wed Sep 08 2010 08:37:47
@juneholley thanks. Yes, more updates to come today from the #XMRV workshop.
Wed Sep 08 2010 08:31:42 in reply to juneholley
Cleveland Clinic-led study: Exercise protects against Alzheimer's
http://ow.ly/2B2Yg
Wed Sep 08 2010 08:12:32
Cleveland Clinic researcher helps organize international #XMRV meeting
http://ow.ly/2B2J9
Wed Sep 08 2010 08:03:24
9/07
Here’s link to Web cast for wrap-up Q&A session scheduled for 5:15 p.m. ET Wednesday
http://ow.ly/2AMK8 #XMRV
Tue Sep 07 2010 17:31:02
Much discussion today of prostate cancer and #XMRV -- CFS will be hot topic at workshop tomorrow.
Tue Sep 07 2010 17:27:11
Over 200 people in attendance, including researchers from around the world. #XMRV
Tue Sep 07 2010 16:52:52
Reps from CDC, FDA, NIH/NCI and more are in attendance at #XMRV workshop
Tue Sep 07 2010 16:52:08
#XMRV is associated with prostate cancer and CFS in some, but not all studies
Tue Sep 07 2010 16:32:01
This research suggests that the prostate is an easy place for #XMRV to grow
Tue Sep 07 2010 16:31:09
Silverman: Another factor causing #XMRV to infect the prostate is hormone levels; higher androgen levels correlate to more XMRV infection
Tue Sep 07 2010 16:30:35
Dr. Robert Silverman of @ClevelandClinic discussing findings that suggest how #XMRV might contribute to prostate cancer development.
Tue Sep 07 2010 16:09:51
Much discussion about the possibility of contamination in samples, populations – it’s a very tricky virus to test for. #XMRV
Tue Sep 07 2010 16:07:25
#XMRV is only the third retrovirus known to infect humans.
Tue Sep 07 2010 16:06:10
It raises the question whether protease inhibitors for HIV (antiretroviral drugs) would be effective in treating #XMRV.
Tue Sep 07 2010 16:05:03
From XMRV workshop: We now know what #XMRV looks like – its structure is similar to HIV but it’s in the details where it’s different.
Tue Sep 07 2010 16:04:24
@kdebelic we'll have more updates soon.
Tue Sep 07 2010 15:49:54 in reply to kdebelic
Collins asked participants at #XMRV workshop to ask penetrating questions.
2:59 PM Sep 7th
NIH director Francis S. Collins opened workshop saying this is timely moment to look at possible roles of #XMRV in CFS and prostate cancer.
2:58 PM Sep 7th
An international group of scientists, physicians and epidemiologists is gathered to discuss the #XMRV virus and present research findings.
2:06 PM Sep 7th
Watch here for updates this afternoon from the 1st International Workshop on #XMRV in Bethesda, Md.
2:06 PM Sep 7th
