Lessons from CROI 2010, a Clinical Context Report
[if: I wonder if this is a mis-quote: Coffin: "But this is very clear evidence that this virus was in fact infecting people" . I can't imagine him saying this. Also, this is the first I've heard of XMRV being investigated in HIV. What did I miss?]
This report is part of a 12-month Clinical Context series.
By Michael Smith, North American Correspondent, MedPage Today
Published: April 09, 2010
Reviewed by Barry S. Zingman, MD; Professor of Clinical Medicine, Albert Einstein College of Medicine, Bronx, NY.
SAN FRANCISCO -- In this exclusive video report, two of the planners of the 2010 Conference on Retroviruses and Opportunistic Infections discuss the major research findings reported here and explain what impact those findings will have on daily clinical practice.
John W. Mellors, MD, chief of the division of infectious diseases at the University of Pittsburgh, and John Coffin, PhD, of the department of microbiology at Tufts University in Boston, sat down with MedPage Today's Michael Smith.
and from the medpage summary:
[if: I wonder if this is a mis-quote: Coffin: "But this is very clear evidence that this virus was in fact infecting people" . I can't imagine him saying this. Also, this is the first I've heard of XMRV being investigated in HIV. What did I miss?]
This report is part of a 12-month Clinical Context series.
By Michael Smith, North American Correspondent, MedPage Today
Published: April 09, 2010
Reviewed by Barry S. Zingman, MD; Professor of Clinical Medicine, Albert Einstein College of Medicine, Bronx, NY.
SAN FRANCISCO -- In this exclusive video report, two of the planners of the 2010 Conference on Retroviruses and Opportunistic Infections discuss the major research findings reported here and explain what impact those findings will have on daily clinical practice.
John W. Mellors, MD, chief of the division of infectious diseases at the University of Pittsburgh, and John Coffin, PhD, of the department of microbiology at Tufts University in Boston, sat down with MedPage Today's Michael Smith.
Coffin: ....XMRV.......Potentially a very exciting result because for any number of reasons; one is because chronic fatigue syndrome has been a very mysterious disease, the other is that the association of prostate cancer was a little unsatisfying in some ways -- that I can get into if you want. But this is very clear evidence that this virus was in fact infecting people and also that in both the prostate cancer study and this one there was a significant fraction of normal controls, uninfected people showed, also showed signs of infection with this virus.
The number being on the order of 4% in the two studies, which if you take that over the whole population of the United States or the whole population of the world that actually turns out to be a very large number of infected individuals.
More, much more, for example in the United States than the total number of HIV infected individuals, and so the possibility of this virus might be associated with this or perhaps other kinds of diseases is a very real one and one that really needs to be investigated and nailed down.
The number being on the order of 4% in the two studies, which if you take that over the whole population of the United States or the whole population of the world that actually turns out to be a very large number of infected individuals.
More, much more, for example in the United States than the total number of HIV infected individuals, and so the possibility of this virus might be associated with this or perhaps other kinds of diseases is a very real one and one that really needs to be investigated and nailed down.
6. A new virus, XMRV, has been implicated in prostate cancer and chronic fatigue syndrome and is being investigated in HIV.