Learn about series- Learn all about Vitamin D relationship to the Immune System and Gene Transcription

CSMLSM

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I will be presenting videos on this particular subject using quality sources of information that explain, demonstrate and illustrate the data and will help us all visualise the research we all do.

This will serve as a resource for learning about the needed understandings to gain a grasp of the biological situation people with ME/CFS find themselves in.

I hope this may be helpful to those seeking answers of their own.

Daniel
 

CSMLSM

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Groundbreaking Vitamin D & Immune System Trial - YouTube

Dr Brad Stanfield Mar 7, 2022 7.27min

A massive human trial of Vitamin D supplements demonstrated a 22% reduction in the development of new autoimmune diseases. This has profound implications for how medicine thinks about Vitamin D supplements

Here are the links to the research papers referenced in the video:
https://www.ncbi.nlm.nih.gov/books/NB...
https://www.ncbi.nlm.nih.gov/books/NB...
https://www.bmj.com/content/356/bmj.i...
https://www.bmj.com/content/376/bmj-2...
https://www.nejm.org/doi/full/10.1056...
https://www.bmj.com/content/376/bmj.o243
 

CSMLSM

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Vitamin-D: Why Does it 'Work' So Well? - YouTube

DrTrevorMarshall Jun 19, 2018 24.54min

This is a video of a presentation given by Prof. Trevor Marshall at the International Congress on
Autoimmunity in Lisbon, Portugal, on 17 May 2018, in the session "Vitamin-D: To D or not to D." A
copy of the abstract can be found at: https://bit.ly/2yiwobx . A copy of the poster presented at ACA
Leipzig "Immunostimulation, a Treatment Innovation" can be found at
http://mpkb.org/_media/home/publicati...
Colleague presentation on ME/CFS recovery: https://www.youtube.com/watch?v=2IMdA...

Other cited resources are linked below,
1. Paper, Vitamin D - The Alternate Hypothesis http://autoimmunityresearch.org/trans...
2. Paper, Vit-D metabolites as Clinical markers: http://autoimmunityresearch.org/prepr...
3. Paper, Vit-D Discovery Outpaces FDA Decision Making http://trevormarshall.com/BioEssays-F...
4. Paper: The Human Microbiome and Autoimmunity http://autoimmunityresearch.org/prepr...
5. Paper: Inflammatory Disease and the Human Microbiome: http://www.discoverymedicine.com/Amy-...
 
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Noticed this paper that may be also pertinent to us, or worth further consideration:

https://pubmed.ncbi.nlm.nih.gov/35517045/

Genetic Variability of the Vitamin D Receptor Affects Susceptibility to Parkinson's Disease and Dopaminergic Treatment Adverse Events

Abstract
Vitamin D is a lipid-soluble molecule and an important transcriptional regulator in many tissues and organs, including the brain. Its role has been demonstrated also in Parkinson's disease (PD) pathogenesis. Vitamin D receptor (VDR) is responsible for the initiation of vitamin D signaling cascade. The aim of this study was to assess the associations of VDR genetic variability with PD risk and different PD-related phenotypes. We genotyped 231 well characterized PD patients and 161 healthy blood donors for six VDR single nucleotide polymorphisms, namely rs739837, rs4516035, rs11568820, rs731236, rs2228570, and rs1544410. We observed that VDR rs2228570 is associated with PD risk (p< 0.001). Additionally, we observed associations of specific VDR genotypes with adverse events of dopaminergic treatment. VDR rs1544410 (GG vs. GA + AA: p = 0.005; GG vs. GA: p = 0.009) was associated with the occurrence of visual hallucinations and VDR rs739837 (TT vs. GG: p = 0.036), rs731236 (TT vs. TC + CC: p = 0.011; TT vs. TC: p = 0.028; TT vs. CC: p = 0.035), and rs1544410 (GG vs. GA: p = 0.014) with the occurrence of orthostatic hypotension.

We believe that the reported study may support personalized approach to PD treatment, especially in terms of monitoring vitamin D level and vitamin D supplementation in patients with high risk VDR genotypes.
 

CSMLSM

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Cannabidiol improves thyroid function via modulating vitamin D 3 receptor in vitamin D 3 deficiency diet-induced rat model - PubMed (nih.gov)
Abstract
The study was evaluated the impact of cannabidiol (CBD) on thyroid hormones by modulation cannabinoid receptor-2 (CB2) and vitamin D receptor (VDR) in rats fed with vitamin D3 deficiency diet (VDD). CB2-receptors were analyzed by RT-PCR method and others biomarkers by ELISA. The relative expression of CB2 (thyroid ~ 4 folds), VDR protein (liver, 151.72%), and (kidney, 66%) was significantly increased in CBD-60 compared to VDD. Vitamin D3 metabolites were significantly increased serum (189.42%), kidney (73.84%), and liver (58.11%) in CBD-60 than VDD. Increased thyroxine (59.9%) and calcitonin (213.59%); while decreased thyroid-stimulating hormone (36.15%) and parathyroid hormone (38.64%) was observed CBD treatment in VDD rats. In conclusion, CBD treatment improves CB2 and VDR expression and the level of vitamin D3 metabolites, along with improved thyroid hormones, including calcitonin. This is the first report with an improved CB2 and VDR expression after CBD treatment in VDD induced animals. Thus, CBD can be considered to use in hypothyroidism conditions and to maintain bone health.