LDN is an immunomodulator; should it be pulsed?

[Hip]

Low-dose naltrexone (LDN) can be considered to be an immunomodulator. Should it be pulsed?

Many immunomodulators (such as Imunovir, Nexavir, artesunate, and azithromycin) are best used on a pulsed, on/off basis. Dr Cheney often makes the point that these immunomodulators lose their effect if you do not take regular breaks from them. Regular breaks means taking them on an on/off regimen, such as for example: on for 5 days, off for 2 days; and/or on for 3 weeks, off for 1 week.

However, other immunomodulators like oxymatrine (this is assumed to be an immunomodulator) should not be stopped if you are deriving benefit from it, as according to Dr Chia, stopping oxymatrine if it is working for you generally causes relapse of symptoms.

Anyway, I wonder if there is any advice given for pulsing LDN, and whether anyone has tried a pulsed LDN regimen, and found it better than taking LDN continuously?

Note that LDN may not work unless you also take vitamin D3.

 

[alex3619]

Hi Hip, that is a good question. I have wondered about it myself. So far I have not tested this. Bye, Alex

 

[Ninan]

For me it stopped working after taking it every day for a few weeks. Maybe it would have lasted longer with pulsing.

 

[nsdn]

Up!

 

[Sushi]

Anyway, I wonder if there is any advice given for pulsing LDN, and whether anyone has tried a pulsed LDN regimen, and found it better than taking LDN continuously?

I've inadvertently pulsed it over the years when I have occasionally run out. The "gap" just brought back symptoms. I seem to do best with daily dosing.

 

[Seven7]

Same for me. Doctor never told me to pulse it. Also the start up is brutal. No way I could tolerate pulsing. My brain swells and I cannot stay awake when increasing dose. So I am basically unconscious for 3 days ( wake up to eat and bathroom but that is about it)

 

[denlander]

Low-dose naltrexone (LDN) can be considered to be an immunomodulator. Should it be pulsed?

Many immunomodulators (such as Imunovir, Nexavir, artesunate, and azithromycin) are best used on a pulsed, on/off basis. Dr Cheney often makes the point that these immunomodulators lose their effect if you do not take regular breaks from them. Regular breaks means taking them on an on/off regimen, such as for example: on for 5 days, off for 2 days; and/or on for 3 weeks, off for 1 week.

However, other immunomodulators like oxymatrine (this is assumed to be an immunomodulator) should not be stopped if you are deriving benefit from it, as according to Dr Chia, stopping oxymatrine if it is working for you generally causes relapse of symptoms.

Anyway, I wonder if there is any advice given for pulsing LDN, and whether anyone has tried a pulsed LDN regimen, and found it better than taking LDN continuously?

Note that LDN may not work unless you also take vitamin D3.

WE Use Hepapressin which seems to act well on the methylation cycle in the immune system
Derek Enlander MD

 

[panckage]

I'm still having trouble finding the best LDN dosing schedule but so far I have found 2 weeks on followed by 2 weeks off to be the best compromise. I always thought it was tolerance that lead to its reduced effect but perhaps it is pulsing instead