https://journals.sagepub.com/doi/full/10.1177/1178646920936279
The title is: Potential Role of Neuroactive Tryptophan Metabolites in Central Fatigue: Establishment of the Fatigue Circuit
The paper is about what causes central fatigue, and there's a nice explanation of the three types of fatigue and why serotonin and lactic acid are not the cause of fatigue. Their conclusion: "Neuroactive tryptophan metabolites are a major cause of central fatigue." This is a lengthy paper (tough for us with central fatigue) but I think it's a must-read for those interested in central fatigue and the role of kynurenines in ME.
I admit I'm biased about the paper because it fits what I've observed with my ME, and the vague hypotheses I'd arrived at.
The title is: Potential Role of Neuroactive Tryptophan Metabolites in Central Fatigue: Establishment of the Fatigue Circuit
The paper is about what causes central fatigue, and there's a nice explanation of the three types of fatigue and why serotonin and lactic acid are not the cause of fatigue. Their conclusion: "Neuroactive tryptophan metabolites are a major cause of central fatigue." This is a lengthy paper (tough for us with central fatigue) but I think it's a must-read for those interested in central fatigue and the role of kynurenines in ME.
I admit I'm biased about the paper because it fits what I've observed with my ME, and the vague hypotheses I'd arrived at.