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Hmm.
I think we know what the disease is when B cells get into the brain and cause inflammation. It is called multiple sclerosis and has pretty little similarity in terms of pathology to ME. B cells are not inflammatory cells until they turn into plasma cells, as they do in MS and produce oligoclonal antibodies. When they do get into brain they tend to cause clear cut damage with demyelination. And as someone pointed out, the time scale does not fit for Younger's theory. My impression is that Younger is dipping his toe into a complex field that he is not very familiar with.
Interesting to see the group led by Steve Hauser talking of B cells as drivers of MS (@Never Give Up). When I talked about this at a meeting in California some years ago he and his friends poo-pooed the idea that this was B cell driven - they were stuck with T cells. But they will learn!! He may yet to learn that the B cells are working through the very antibodies they have been studying, or maybe he has even worked that out already.
I think we know what the disease is when B cells get into the brain and cause inflammation. It is called multiple sclerosis and has pretty little similarity in terms of pathology to ME. B cells are not inflammatory cells until they turn into plasma cells, as they do in MS and produce oligoclonal antibodies. When they do get into brain they tend to cause clear cut damage with demyelination. And as someone pointed out, the time scale does not fit for Younger's theory. My impression is that Younger is dipping his toe into a complex field that he is not very familiar with.
Interesting to see the group led by Steve Hauser talking of B cells as drivers of MS (@Never Give Up). When I talked about this at a meeting in California some years ago he and his friends poo-pooed the idea that this was B cell driven - they were stuck with T cells. But they will learn!! He may yet to learn that the B cells are working through the very antibodies they have been studying, or maybe he has even worked that out already.