Busson
Senior Member
- Messages
- 102
It's a common recommendation that if you have a methylfolate trap (an accumulation of unprocessed methylfolate which exits the cell to leave a state of folate deficiency) then it can be broken by taking very large quantities of methylfolate.
(This approach assumes you have dealt with any B12 problem which might have been causing the methylfolate to accumulate.)
My own experience is that taking a lot of methylfolate when you have a methylfolate trap only makes things much worse. I wasn't willing to risk the gargantuan doses that I sometimes read about, such as 10 or 20 mg, but I found that my folate trap symptoms would resolve on their own after several days if I took no folate.
Is there any scientific research or biological explanation to support the idea that very large doses of folate can break a methylfolate trap? My Googling hasn't found anything.
(This approach assumes you have dealt with any B12 problem which might have been causing the methylfolate to accumulate.)
My own experience is that taking a lot of methylfolate when you have a methylfolate trap only makes things much worse. I wasn't willing to risk the gargantuan doses that I sometimes read about, such as 10 or 20 mg, but I found that my folate trap symptoms would resolve on their own after several days if I took no folate.
Is there any scientific research or biological explanation to support the idea that very large doses of folate can break a methylfolate trap? My Googling hasn't found anything.