Is there any infections that can last over 25 years?

[Booble]

To make things even more complicated, as if they are not already complicated enough. I have chronic congestion, sneezing, and a runny nose and have for years. I think I have Nonallergic rhinitis.

Nonallergic rhinitis doesn't involve the immune system. Yet causes sneezing, congestion, and a runny nose just like a cold, a flu, or a true allergy.

Same here. I have both allergic and non allergic. With the latter my nose gets clogged up feeling not runny. Happens many times throughout the day from various triggers. Primarily one sided (left).

 

[Wishful]

This is why CFS/ME/Fibro is so resistant and difficult to get lasting results.

No, I don't think ME is as simple as a particularly tough microbial infection. If it was, I wouldn't have had so many temporary remissions from various treatments, many of which are not known for being antimicrobial.

I believe that microbial infections can worsen ME, and trigger them in the first place, but that they aren't the core dysfunction. I still think the core dysfunction is a positive feedback loop, which might be inside some cells, or might involve extra-cellular processes as well.