Investigators Discover Key Parkinson’s Disease Protein “Toggle Switch”

Wishful

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https://scitechdaily.com/investigators-discover-key-parkinsons-disease-protein-toggle-switch/

"The authors describe alpha-synuclein as a “toggle switch” that regulates two very distinct functions: transport of vesicles and gene expression. In disease states, the balance is broken."

News about alpha-synuclein catches my attention because cumin (so effective for me as a PEM-blocker) inhibits the agglomeration of this protein, and is thus a possible explanation for why it worked for me. I also consider ME to be a 'toggled state' that we can switch into and out of, so any sort of neuro-molecular toggle switch catches my attention.

Hardly a breakthrough for ME, but I thought the potential connection was interesting. BTW, baicalin, which some members here find beneficial for their ME, also inhibits A-syn agglomeration.
 

hapl808

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Interesting. I've restarted a version of Buhner (skullcap, knotweed, cat's claw, andrographis) that has helped me in the past. I always hit a plateau, but it seems to help with some of the physical and mental PEM crashes. Or at least raises my threshold a bit.
 

GreenEdge

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From a another study:
Cross-Reactivity and Sequence Homology Between Alpha-Synuclein and Food Products: A Step Further for Parkinson's Disease Synucleinopathy
Results: While the antibody made against recombinant α-synuclein reacted significantly with 86/180 specific food antigens, the antibody made against α-synuclein epitope 118-123 reacted with only 32/180 tested food antigens. The food proteins with the greatest number of peptides that matched with α-synuclein were yeast, soybean, latex hevein, wheat germ agglutinin, potato, peanut, bean agglutinin, pea lectin, shrimp, bromelain, and lentil lectin.

Conclusions: The cross-reactivity and sequence homology between α-synuclein and frequently consumed foods, reinforces the autoimmune aspect of Parkinson's disease.
Above, I underlined the foods to avoid.