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Interactions of several mutations in Methylation

Many of us have read on the effects of the individual mutation, but the systemic effects of the several mutations remain puzzling with all the debates about Yasko. Does anyone have sources on the interaction effects? I am very confused about the interpretation of just four mutations in bold below. What do you think the interaction effects are?

Gene & Variation rsID Alleles Result
COMT V158M rs4680 AG +/-
COMT H62H rs4633 CT +/-
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 CC -/-
VDR Taq rs731236 AA +/+
MAO A R297R rs6323 T +/+
ACAT1-02 rs3741049 GG -/-
MTHFR C677T rs1801133 AA +/+
MTHFR 03 P39P rs2066470 GG -/-
MTHFR A1298C rs1801131 TT -/-
MTR A2756G rs1805087 AA -/-
MTRR A66G rs1801394 GG +/+
MTRR H595Y not found n/a not genotyped
MTRR K350A rs162036 AA -/-
MTRR R415T not found n/a not genotyped
MTRR A664A rs1802059 GG -/-
BHMT-02 rs567754 CC -/-
BHMT-04 not found n/a not genotyped
BHMT-08 rs651852 CC -/-
AHCY-01 rs819147 TT -/-
AHCY-02 not found n/a not genotyped
AHCY-19 rs819171 TT -/-
CBS C699T rs234706 GG -/-
CBS A360A rs1801181 AA +/+
CBS N212N not found n/a not genotyped
SHMT1 C1420T not found n/a not genotyped


Senior Member
Boston, Massachusetts
Try going to @caledonia's profile page, click on her 'Information' and from there, in her 'Signature', go to her Methylation Links. #2 is her SNPs Interpretation Guide, which will give you some basic information, particularly on the SNPs you've highlighted. They're some of the standard ones we examine. You might also head to the Phoenix Rising Forums, and under 'Treatment and Therapy,' click on 'Genetic Testing and Snps,' where there are innumerable threads dealing with snps. @Valentijn has also compiled some very useful information about snps, focussing on the scholarly work behind the practices that many working on methylation have found invaluable.

There's a wealth of information here if you know where to look for it!

Best wishes!