G
EVENT DESCRIPTION Event Type: Seminar (This is an NIH Science event)
Title: Interactions between APOBEC3 proteins, HIV-1, and XMRV
Description: Current advances in our understanding of intracellular immunity conferred by host cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) and the mechanism by which the virally encoded virion infectivity factor (Vif) protein induces their proteasomal degradation provide fresh opportunities for the development of novel antiviral treatments. Interestingly, the Vif A3G and Vif A3F interactions that overcome this host defense mechanism are structurally distinct and provide two potential targets for antiviral drug development.
Recent studies have reported the first gammaretrovirus that infects humans, named xenotropic murine leukemia virus-related virus (XMRV). XMRV was isolated from human prostate cancer tissue and from activated CD4+ T cells and B cells of patients with chronic fatigue syndrome, suggesting an association between XMRV infection and these two disease states. Since APOBEC3G (A3G) and APOBEC3F (A3F), which are potent inhibitors of the murine leukemia virus and Vif-deficient human immunodeficiency virus type 1 (HIV-1), are expressed in human CD4+ T cells and B cells, we sought to determine how XMRV evades suppression of replication by APOBEC proteins. We found that XMRV infectivity is potently inhibited by A3G and A3F, and to a lesser extent, by murine APOBEC3. Overall, these results suggest that the establishment of XMRV infection in patients may be dependent on infection of A3G/A3F-deficient cells and that prostate epithelial cells may provide an ideal target for XMRV replication and spread.
Series Name: Virology Interest Group
Event URL: http://sigs.nih.gov/VIG/Pages/Meetings.aspx
Videocast: Event will not be videocast
Special Instructions: To arrange sign language interpretation for an event go to the Office
of Research Services (ORS) Interpreting Service Requests web page. EVENT DATE/TIME Date/Time: Thursday, April 01, 2010 12:00pm - 1:00pm
EVENT SPEAKER(S) Name: Vinay K. Pathak
Title: Ph.D. Organization: Viral Mutation Section, HIV Drug Resistance Program, CCR, NCI City/Province: Frederick State: Maryland
EVENT SPONSOR(S) Organization(s): [NIH] Virology Interest Group
EVENT LOCATION Location: On the main NIH Campus Building: Building 4 Room: 433 Street Address: 4 Center Drive City: Bethesda State: Maryland Zip Code: 20892
EVENT CONTACT(S) Name: Gaelle Kolb E-mail: kolbg@mail.nih.gov Phone: 301-443-5582
Title: Interactions between APOBEC3 proteins, HIV-1, and XMRV
Description: Current advances in our understanding of intracellular immunity conferred by host cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) and the mechanism by which the virally encoded virion infectivity factor (Vif) protein induces their proteasomal degradation provide fresh opportunities for the development of novel antiviral treatments. Interestingly, the Vif A3G and Vif A3F interactions that overcome this host defense mechanism are structurally distinct and provide two potential targets for antiviral drug development.
Recent studies have reported the first gammaretrovirus that infects humans, named xenotropic murine leukemia virus-related virus (XMRV). XMRV was isolated from human prostate cancer tissue and from activated CD4+ T cells and B cells of patients with chronic fatigue syndrome, suggesting an association between XMRV infection and these two disease states. Since APOBEC3G (A3G) and APOBEC3F (A3F), which are potent inhibitors of the murine leukemia virus and Vif-deficient human immunodeficiency virus type 1 (HIV-1), are expressed in human CD4+ T cells and B cells, we sought to determine how XMRV evades suppression of replication by APOBEC proteins. We found that XMRV infectivity is potently inhibited by A3G and A3F, and to a lesser extent, by murine APOBEC3. Overall, these results suggest that the establishment of XMRV infection in patients may be dependent on infection of A3G/A3F-deficient cells and that prostate epithelial cells may provide an ideal target for XMRV replication and spread.
Series Name: Virology Interest Group
Event URL: http://sigs.nih.gov/VIG/Pages/Meetings.aspx
Videocast: Event will not be videocast
Special Instructions: To arrange sign language interpretation for an event go to the Office
of Research Services (ORS) Interpreting Service Requests web page. EVENT DATE/TIME Date/Time: Thursday, April 01, 2010 12:00pm - 1:00pm
EVENT SPEAKER(S) Name: Vinay K. Pathak
Title: Ph.D. Organization: Viral Mutation Section, HIV Drug Resistance Program, CCR, NCI City/Province: Frederick State: Maryland
EVENT SPONSOR(S) Organization(s): [NIH] Virology Interest Group
EVENT LOCATION Location: On the main NIH Campus Building: Building 4 Room: 433 Street Address: 4 Center Drive City: Bethesda State: Maryland Zip Code: 20892
EVENT CONTACT(S) Name: Gaelle Kolb E-mail: kolbg@mail.nih.gov Phone: 301-443-5582