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Integration of DNA methylation & health scores identifies subtypes in myalgic encephalomyelitis/chronic fatigue syndrome.
de Vega WC1,2,Erdman L3,4,Vernon SD5,Goldenberg A3,4,McGowan PO1,2,6,7.
Author information
Abstract
AIM:
To identify subtypes in myalgic encephalomyelitis/chronic fatigue syndrome(ME/CFS) based on DNA methylation profiles and health scores.
METHODS:
DNA methylome profiles in immune cells were integrated with symptomatology from 70 women with ME/CFS using similarity network fusion to identify subtypes.
RESULTS:
We discovered four ME/CFS subtypes associated with DNA methylation modifications in 1939 CpG sites, three RAND-36 categories and five DePaul Symptom Questionnaire measures. Methylation patterns of immune response genes and differences in physical functioning and postexertional malaise differentiated the subtypes.
CONCLUSION:
ME/CFS subtypes are associated with specific DNA methylation differences and health symptomatology and provide additional evidence of the potential relevance of metabolic and immune differences in ME/CFS with respect to specific symptoms.
KEYWORDS:
CFS; DNA methylation;chronic fatigue syndrome; clinical subtyping; complex disease; epigenetics; health survey; myalgic encephalomyelitis; similarity network fusion; symptom heterogeneity
de Vega WC1,2,Erdman L3,4,Vernon SD5,Goldenberg A3,4,McGowan PO1,2,6,7.
Author information
Abstract
AIM:
To identify subtypes in myalgic encephalomyelitis/chronic fatigue syndrome(ME/CFS) based on DNA methylation profiles and health scores.
METHODS:
DNA methylome profiles in immune cells were integrated with symptomatology from 70 women with ME/CFS using similarity network fusion to identify subtypes.
RESULTS:
We discovered four ME/CFS subtypes associated with DNA methylation modifications in 1939 CpG sites, three RAND-36 categories and five DePaul Symptom Questionnaire measures. Methylation patterns of immune response genes and differences in physical functioning and postexertional malaise differentiated the subtypes.
CONCLUSION:
ME/CFS subtypes are associated with specific DNA methylation differences and health symptomatology and provide additional evidence of the potential relevance of metabolic and immune differences in ME/CFS with respect to specific symptoms.
KEYWORDS:
CFS; DNA methylation;chronic fatigue syndrome; clinical subtyping; complex disease; epigenetics; health survey; myalgic encephalomyelitis; similarity network fusion; symptom heterogeneity