Inflamed dorsal root ganglion-- spinal disc herniation worsen the symptoms?

lauluce

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This thread is split from Donating our bodies to ME Science.

I am a member of the UK post-mortem research group and the results on some of the post mortems that have been carried out so far here in the UK have been published - see below

However, none of the post-mortems carried out so far have found the sort of widespread and significant neuroinflammation that would be consistent with an encephalomyelitis (ie inflammation of brain and spinal cord)

The dorsal root ganglion (where inflammation has been found) forms part of the peripheral nervous system

We are continuing to carry out post-mortems when the opportunity arises

If you live in the UK you can use our 'Statement of Intent' form on the MEA website to register your permission for body parts and tissues to be used for post mortem research into ME/CFS:

http://www.meassociation.org.uk/wp-content/uploads/MEA-RRF-Statement-of-Intent-2015.pdf

I am not aware of any ME/CFs charities outside the UK who are doing this kind of research

This work is not yet directly linked to the work of the ME/CFS Biobank that we fund at the Royal Free Hospital in London. The ME/CFS Biobank is currently only dealing with collection, storage and distribution of blood samples with the anonymised clinical data attached

Dr Charles Shepherd
Hon Medical Adviser, MEA

Pathology of Chronic Fatigue Syndrome: Pilot Study of Four Autopsy Cases
DG O’Donovan1, 2, T Harrower3, S Cader2, LJ Findley2, C Shepherd4, A Chaudhuri2
1Addenbrooke’s Hospital Cambridge UK
2Queen’s Hospital Romford Essex UK
3Royal Devon & Exeter Hospitals UK
4Honorary Medical Advisor to ME Association UK

Chronic Fatigue Syndrome / Myalgic Encephalomyelitis is a disorder characterised by chronic exercise induced fatigue, cognitive dysfunction, sensory disturbances and often pain. The aetiology and pathogenesis are not understood.

We report the post mortem pathology of four cases of CFS diagnosed by specialists.

The causes of death were all unnatural and included: suicidal overdose, renal failure due to lack of food and water, assisted suicide and probable poisoning.

Selected portions of tissue were made available by the various Coroners in the UK and with the assent of the persons in a qualifying relationship.

The cases were 1 male, and 3 female. Ages (years) M32, F32, F43 & F31.

One case showed a vast excess of corpora amylacea in spinal cord and brain of unknown significance but Polyglucosan Body Disease was not supported by clinicopathologial review. No ganglionitis was identified.
One case showed a marked dorsal root ganglionitis and two other cases showed mild excess of lymphocytes with nodules of nageotte in the dorsal root ganglia.

This raises the hypothesis that dysfunction of the sensory and probably also the autonomic nervous system may lead to abnormal neural activity eg hyperalgesia & allodynia rather than anaesthesia and may explain some of the symptoms of CFS / ME such as pain, hypotension, hyperacusis and photophobia. However, the syndrome may be heterogeneous.

Nevertheless, the precise relationship of fatigue, which may be either peripheral or central, to abnormalities in the peripheral nervous system (PNS) needs to be studied.

The differential diagnosis of ganglionitis should be investigated in CFS / ME patients hence Varicella Zoster, Lyme disease, HIV, Sjogren’s disease, paraneoplastic sensory ganglionopathy should be excluded by appropriate history and tests.

Thorough histopathological study of cases coming to autopsy may help to confirm or refute the hypothesis, that CFS is a disease process, and whether the symptomatology may be explained by inflammation of the sensory and autonomic divisions of the PNS.

A specific CFS / ME brain and tissue bank in the UK is proposed.

Dorsal root ganglion anatomy:

I've got a question about this... if ME where related to inflammation in these dorsal root ganglion, would it be possible for a a spinal disc herniation to worsen the symptoms of the disease? thanks!
 
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I've got a question about this... if ME where related to inflammation in these dorsal root ganglion, would it be possible for a a spinal disc herniation to worsen the symptoms of the disease? thanks!
Interesting question!

I'm afraid I cannot go any further than to say it is a theoretical possibility

I am not aware of any ME/CFS post mortems where disc herniation has been reported in addition to dorsal root ganglionitis

CS
 

lauluce

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Interesting question!

I'm afraid I cannot go any further than to say it is a theoretical possibility

I am not aware of any ME/CFS post mortems where disc herniation has been reported in addition to dorsal root ganglionitis

CS
My ME/CFS clearly worsened after suffering disk herniation, which after nerve conductivity studies proved to be severeley afecting my nerves downwards from the lessons. If you think about it, there's no way to tell what exactly was the damage I suffered at that area besides the herniated disc, other structures in the area could have been affected. Is there a way to study the condition of these root ganglions on a live person?
 

lauluce

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I think that anything that activates the immune system, which includes physical cell damage, is likely to worsen CFS symptoms.
I think exactly the same, my friend, ANYTHING that produces inflammation worsens ME/CFS. I have poor dental hygiene precisely because I found a little exhausting to wash my teeth properly... anybody has this problem? regarding the spinal issue, I was thinking about buying a device that stretches the spine, that might have some potential to improve the condition of damaged espinal disks , it is this one, sorry that it is in spanish, but in the middle of the video it is shown how it works:
what do you thing about a device like this? could it be any good?
 

lauluce

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here I am again... three days ago I started having the same pain the herniation I mentioned in this post caused, but higher up in my spine, I think I suffered another disk herniation, but in a different disk. I just wish this doesn't worsen my symptoms! I'll keep you updated