Improvement of cognitive function in ... Alzheimer´s disease mouse models by the immunomodulatory properties of menthol inhalation; Casares, 4/23

[Mary]

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1130044/full

, , , repeated short exposures to menthol odor enhanced the immune response against ovalbumin immunization. Menthol inhalation also improved the cognitive capacity of immunocompetent mice but not in immunodeficient NSG mice, which exhibited very poor fear-conditioning. This improvement was associated with a downregulation of IL-1β and IL-6 mRNA in the brain´s prefrontal cortex, and it was impaired by anosmia induction with methimazole. Exposure to menthol for 6 months (1 week per month) prevented the cognitive impairment observed in the APP/PS1 mouse model of Alzheimer. Besides, this improvement was also observed by the depletion or inhibition of T regulatory cells. Treg depletion also improved the cognitive capacity of the APPNL-G-F/NL-G-F Alzheimer´s mouse model. In all cases, the improvement in learning capacity was associated with a downregulation of IL-1β mRNA. Blockade of the IL-1 receptor with anakinra resulted in a significant increase in cognitive capacity in healthy mice as well as in the APP/PS1 model of Alzheimer´s disease.

I think this is a fascinating - the capacity of menthol to improve cognitive capacity in healthy mice as well as those with Alzheimer's - maybe it would help with brain fog?


https://www.msn.com/en-us/news/othe...1&cvid=997c50e51471490b91afa760dadb43ea&ei=26