Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection

[SWAlexander]

Abstract
A proportion of patients surviving acute coronavirus disease 2019 (COVID-19) infection develop post-acute COVID syndrome (long COVID (LC)) lasting longer than 12 weeks. Here, we studied individuals with LC compared to age- and gender-matched recovered individuals without LC, unexposed donors and individuals infected with other coronaviruses. Patients with LC had highly activated innate immune cells, lacked naive T and B cells and showed elevated expression of type I IFN (IFN-β) and type III IFN (IFN-λ1) that remained persistently high at 8 months after infection. Using a log-linear classification model, we defined an optimal set of analytes that had the strongest association with LC among the 28 analytes measured. Combinations of the inflammatory mediators IFN-β, PTX3, IFN-γ, IFN-λ2/3 and IL-6 associated with LC with 78.5–81.6% accuracy. This work defines immunological parameters associated with LC and suggests future opportunities for prevention and treatment.
more at: https://www.nature.com/articles/s41590-021-01113-x

 

[godlovesatrier]

To examine biomarkers associated with LC, we assessed 28 analytes in the serum of patients from the LC, MC, HCoV and UHC groups at month 4 after infection using a bead-based assay. Six proinflammatory cytokines (interferon β (IFN-β), IFN-λ1, IFN-γ, CXCL9, CXCL10, interleukin-8 (IL-8) and soluble T cell immunoglobulin mucin domain 3 (sTIM-3)) were elevated in the LC and MC groups compared to the HCoV and UHC groups (Fig. 1), with no difference observed in the 22 other analytes, including IL-6 and IL-33 (Extended Data Fig. 1).

 

[SWAlexander]

My dr. report just came in. Diagnosis: Antiphospholipid syndrome.

Seeking help for more information.
I couldn't find much on Google.
Thank you.

 

[perrier]

My dr. report just came in. Diagnosis: Antiphospholipid syndrome.

Seeking help for more information.
I couldn't find much on Google.
Thank you.

https://my.clevelandclinic.org/health/diseases/21685-antiphospholipid-syndrome

 

[SWAlexander]

https://my.clevelandclinic.org/health/diseases/21685-antiphospholipid-syndrome

Thank you very much.
Now I found, in addition to your link, a YouTube presentation by Associate Professor Dr. Michael Linenberger, who explains Antiphospholipid syndrome. There are many more related illnesses such as brain white matter (memory), nephropathy and and. Most of them remain undetected if not specifically tested for.