IMD Berlin, My test for inflammation/ IL-1 beta, IL-1ra, BDNF, RANTES, AGE, help!

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There is a study that shows that what you have tested is elevated in ME/CFS patients. It shows you that you have an inflammation. I don’t think you have to visit a dentist because of RANTES
 

pattismith

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High IL-1 and low IL-1ra are consistent with inflammation, but you probably already know this!
Yes I do, but I'm not used to these tests, and I don't have knowledge about consensus on reference ranges.:)

I'm also a bit concerned because I did test my blood one month before in a french lab and they found my IL-1beta was less than 5 pg/ml (normal).

On the other hand low IL-1ra/high IL-1 beta would match well with my brain neuroinflammation, so I guess it's a logical target to improve my illness.:thumbsup:

There is a study that shows that what you have tested is elevated in ME/CFS patients. It shows you that you have an inflammation. I don’t think you have to visit a dentist because of RANTES
thank you for your reply Martin, :hug:
before testing, I was curious about my IL-8, because it was found high in some studies, but mine seems ok.
 
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Yes I do, but I'm not used to these tests, and I don't have knowledge about consensus on reference ranges.:)

I'm also a bit concerned because I did test my blood one month before in a french lab and they found my IL-1beta was less than 5 pg/ml (normal).

On the other hand low IL-1ra/high IL-1 beta would match well with my brain neuroinflammation, so I guess it's a logical target to improve my illness.:thumbsup:


thank you for your reply Martin, :hug:
before testing, I was curious about my IL-8, because it was found high in some studies, but mine seems ok.
Really? Didn't find any study. Mine is high. But RANTES BDNF etc are low except IL-1beta... Shows how much we differ
 

Hip

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no, but maybe it would be a good idea to do a checkup with a dentist
A regular dentist is unlikely to be able to help. For jawbone cavitation infections, it is only a handful of dentists who know how to test for these. Some info in the jawbone cavitation section of my roadmap.

Typically a jawbone cavitation occurs when wisdom teeth are removed, and the periodontal ligament is not properly cleaned out.


Some papers of interest:
 

pattismith

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Really? Didn't find any study. Mine is high. But RANTES BDNF etc are low except IL-1beta... Shows how much we differ
So we have common IL-1beta upregulation.

Down regulation can be target by TLR2 inhibition or Caspase 1 inhibition.

Naltrexone can inhibit TLR2 (the dose needed to achieve it is higher than the LDN), Azithromycin, Doxycycline, ..



1623698285512.png
 

pattismith

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A regular dentist is unlikely to be able to help. For jawbone cavitation infections, it is only a handful of dentists who know how to test for these. Some info in the jawbone cavitation section of my roadmap.

Typically a jawbone cavitation occurs when wisdom teeth are removed, and the periodontal ligament is not properly cleaned out.
Thank you @Hip , I didn't have any teeth removed so not a good candidate for this affection, but I read RANTES can rise with glucose intolerance and diabete type 2.

This is probably my case, as I realized yesterday my post prandial glycemia was very high. It's probably driven by my modafinil intake, so it's just one more drug I have to stop because of the side effects...
 

mitoMAN

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To quote the ME/CFS CYTOKINE study in my previously started thread:
The association of plasma cytokines with diagnosis and symptoms of ME: .... diagnosis of ME/CFS is significantly associated with increased plasma content of IL-10, MIP-1β, and RANTES and lower PDGF, IL-6, eotaxin, MIP-1α and VEGF. ...... higher plasma values of IL-1β, IL-8, IL-10, IP-10, and RANTES were significantly associated with higher Chalder Fatigue scores i.e. greater perceived fatigue"


https://forums.phoenixrising.me/thr...nts-with-myalgic-encephalomyelitis-cfs.81197/


RANTES is now heavily found in long covid too and doesnt seem to be related to any jawbone damage but rather damage of blood vessles.