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If there is a factor in the serum, why is plasma exchange not working?

Messages
65
Well, how would you even remove something if you don't know what it is in the first place, where it is, and how much? You can't remove something if you don't even know if it's in the sample of blood that you took. What if it's an mRNA that's constantly produced by a virus? Then it doesn't really matter how many plasma exchanges you do. The "new" blood will carry the "factor." And you also can't remove all of the plasma from the human body, otherwise you'd die.
 

bread.

Senior Member
Messages
499
Well, how would you even remove something if you don't know what it is in the first place, where it is, and how much? You can't remove something if you don't even know if it's in the sample of blood that you took. What if it's an mRNA that's constantly produced by a virus? Then it doesn't really matter how many plasma exchanges you do. The "new" blood will carry the "factor." And you also can't remove all of the plasma from the human body, otherwise you'd die.

Well, that does not add up to me, you should definitely see some improvement with PLEX .Also, you do not have to remove a specific factor in isolation when you per definition remove the fluid that holds the factor. Also it is an EXCHANGE of Plasma, you do not just take Plasma out.
 

JES

Senior Member
Messages
1,335
Immunoabsorption (which is a specific form of plasma exchange) did show results in a pilot study (source), although a bit of a limitation was that they relied on self-reported symptom changes.
 

bread.

Senior Member
Messages
499
Immunoabsorption (which is a specific form of plasma exchange) did show results in a pilot study (source), although a bit of a limitation was that they relied on self-reported symptom changes.

that is weak stuff,... to me it is actually a negative outcome,...
 
Messages
11
That is because CFS/Fibro is not in the blood. The effects of CFS are in the blood but if you were to exchange your whole blood with an identical you(twin?) who did not have CFS then the effects would disappear so quickly that it would not be noticeable IMO.
 
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Wishful

Senior Member
Messages
5,852
Location
Alberta
I agree with Not_ME: the factor might be produced too quickly by cells not exchanged in the plasma to notice any effects. Furthermore, while the factor might be measurable via nanoneedles, that doesn't mean that it's producing significant effects on the patient. It's an identifiable factor, but what it means for the patient is still unknown.
 
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