Do any of your Drs have anything to say about the elevated IGM and or level of your ANA titre? what is the pattern of yours? mine is speckled.
@justy, My ANA pattern is "speckled" like yours and the titer is 1:160 (at least it was in March 2016, I have not tested it since). My main doctor felt the titer was reflective of me having 11 autoantibodies vs. some random coincidence or even a "false positive" like the rheumy said. I only saw the rheumy 2x b/c he was unable to help me. My main doc has never been concerned with the elevated IgM, not sure why.
If the Dr I see has anything to say about them I will let you know for sure.I don't know what they mean for me - ive had autoantibody testing for lupus and RA - both ruled out, but never had any other antibodies looked for. Schirmer test for sjorgrens was negative on one eye and positive on the other so they said it wasn't that.
I am negative for RA and lupus and never tested for Sjogrens but do not have the symptoms of it. I have Hashimoto's (and have been positive for the two Hashi's autoantibodies since 2013 but probably earlier) but my other autoantibodies are more obscure, although I think the GAD65 autoantibody is probably fairly common. I wish you could test for Cell Trend or paraneoplastic autoantibodies to see if you are positive for any of them.
Prior to IVIG, I had the muscle weakness of LEMS, and I also have one of the calcium channel autoantibodies that go with LEMS, yet I also fit partial criteria for other diagnoses, too. My two diagnoses with absolute 100% confirmation are POTS and MCAS and the rest are B-cell autoantibody driven per my doctor but overlap w/several different illnesses. I am like a freak diagnostically

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I was in so MUCH PAIN on IVIG. I honestly thought IVIG was going to kill me.
My very first IVIG in July 2016 was infused at WAY too fast of a rate and I got an excruciating headache/intracranial pressure that by the 10th day, I went to the ER and was given Decadron infusion to reduce the pressure. Ever since then, my MCAS doctor reduced the infusion speed so it takes a minimum of 6-7 hours. So each infusion is an all-day production but I have never gotten a headache like that again and I had IVIG every three wks for 10 months. Infusion speed is absolutely critical in someone with MCAS to avoid third spacing and pulmonary edema (of any fluid, not just IVIG) but especially w/IVIG b/c it is a very thick substance and a slow infusion speed reduces risk of blood clots, too.
You have nine cavities? Do they hurt Ginger? I can't even imagine.
I have absolutely zero pain and would not even know that I had cavities if new dentist did not tell me. I had a great dentist but he retired and his son took over his practice. His son was terrified to treat me b/c of MCAS and basically fired me as a patient and said I could only do dental work in a hospital (which was insane b/c my MCAS has been in remission for 10 months). I think he just did not want any liability if I had an allergic reaction but the reality is that any patient could have an allergic reaction to dental work and you cannot predict vs. I would be taking every precaution known to man and had done extensive research.
So I found a new dentist who I really like and she is the one who said I have nine cavities. The guy who fired me said I have five but he really was not thorough like new one. I have no reason to believe she is lying and I had not seen a dentist in over two yrs b/c my MCAS had been so reactive (prior to IVIG) that it was not possible. Now it is possible and I did a test of the anesthesia w/her recommended by TMS (masto society) and was not allergic. However, the dental adhesives/fillings she uses have yellow dyes (which I am allergic to) so I need to figure out what to do. I got the MSDS (material safety data sheets) thanks to another member of PR and e-mailed them to my new dentist to see how she wants to proceed. I also contacted a holistic dentist and hoping for a call back. Am hoping this info is helpful to you or Justy and I have a whole thread about it where I explain more.