I always used to get a good fever every 1-2 years or so when something was going around, even when others didn't - or when they had low-grade fever, mine was always higher. Then when CFS started with the trigger infection, one notable aspect was that I had no fever at all to match these symptoms, maybe mildly elevated temp, but that was already highly unusual. Then I had no fevers for 5 years except towards the tail-end of my recovery a mild one during a stomach virus. I noted though mildly elevated body temp sometimes after using the MAF-314, nothing really mounting to a fever though. I just had the first high fever again like I used to and did not take any meds except for the first night, letting it run its course all the way to 103+ and back. It was awful but only lasted 2-3 days. I take this as a good sign. I still have residual lymphatic issues but otherwise have signed up for my first half-marathon this year. My guess is that there is a connection between the lack of high-grade fevers (low grade may not count that much as the strength of the immune response is tied to the grade of the fever) and the disease state of CFS patients. Hopefully research will find out more soon enough.