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I just read the SNP Interpretation guide and the 4R gut rebuilding program and although I am overwhelmed and wondering how I can possible do all the listed suggestions, I am also amazed by how many of my health problems have been addressed by those documents.
I want to make a sincere thank you to @caledonia and heartfixer for putting together those guides and I am going to try and decide on the best first steps. Any advice or corrections would be hugely appreciated. Please please, don't let me misunderstand this stuff. I can hardly keep it all straight.
There is a long list of things suggested for my particular situation: (ACAT1 02 (+/-), SHMT --, BHMT-02 (+/-), BHMT-08 (+/+), CBS C699T (+/-), CBS A360A (+/-), VDR BSM (+/+), MAOA (+/-), MTHFR C677T (+/-), MTHFR A1298C (+/-), MTHFR P93P (+/-), MTR A2576G (+/-), PEMT (+/+), APOE4 (+/+).
Sources: AMRI Heartfixer
Snps interpretation guide by caledonia
Wow you read to the bottom. Thanks. I appreciate it!!
Sleepingbeautycan (I think I can I think I can)
I want to make a sincere thank you to @caledonia and heartfixer for putting together those guides and I am going to try and decide on the best first steps. Any advice or corrections would be hugely appreciated. Please please, don't let me misunderstand this stuff. I can hardly keep it all straight.
There is a long list of things suggested for my particular situation: (ACAT1 02 (+/-), SHMT --, BHMT-02 (+/-), BHMT-08 (+/+), CBS C699T (+/-), CBS A360A (+/-), VDR BSM (+/+), MAOA (+/-), MTHFR C677T (+/-), MTHFR A1298C (+/-), MTHFR P93P (+/-), MTR A2576G (+/-), PEMT (+/+), APOE4 (+/+).
- Given that I have limited time and resources I have to pair down the list to the essentials but at this point they all seem to have the same priority.
- I think I should stop the methyls until I get some stuff cleaned up.I am not sure when the CBS gene allows me to take methyls.
- The SNP interpretation guide starts with ACAT1-02 and SHMT C1420T(which 23andme stopped testing) and I think I have had a leaky gut in the past but it seems to be in a pretty good state right now. I had a GI Effects Stool test done about 2 years ago and it showed me being in the green for almost every test. It has only gotten better since then. I was in the yellow for a few of the levels of bacterias but I feel like my gut is in the best shape of 20 years. So I think I am going to use the opportunity to fix some of my poor habits and move on. I will be removing sugars again and add back in my homemade sauerkraut. I will also add back in Gastro_ULC, and Pepcix, as well I will stay on Vitamins A, E, and C. I think I will have to buy ox salts and folinic acid ($45)
- The next snp addressed is CBS. I think for me this is pretty clearly expressed. I have always had problems with sulfa drugs (I assume that they have sulfur in them) and I have had anxiety since taking the Methylfolate. As well, I don't react well to luncheon meat and the like.
- There was a comment about the trapezius muscles. I have had this pain between my shoulder blades (which is where the diagram said the trapezius might be) off and on for the last 3 years and it is hard to take. I have been on some pretty strong pain killers when it is flaring. Could this be caused by ammonia?? If so Hallelujah!!
- I am going to try and follow the free thiol list that @caledonia recommended. I found a copy of the foods you can't have here (the first list). So, no high thiols and l-ornithine l-aspartate ($90)
- I also have at least one snp on the SUOX gene and may cause my PCOS. Or it could be that the CBS is taking all the molybdenum and none is left to the SUOX reaction. So I guess adding molybdenum, vitamin E succinate, and hydroxy-b12 (my amazon bill for all the above supplements is 195 +shipping)
- There is some interaction between CBS, VDR and COMT. I am (-/-) for COMT, (+/+) for VDR and (+/-) for CBS and I think that means that my dopamine is low and I can fix it with CoEnzyme Q10, carnitine and ribose but I am not sure. I am also (+/-) on every single MAOA allele and maybe that impacts things too? I ordered ribose and NAD+.
- I think since I am sensitive to methyls I will pass on the trimethylglycine to support my BHMTs.
- I think since I am sensitive to soy products I am going to pass on Phosphatidylcholine but I will add creatine in order to add back some SAMe.
- Yucca root on any protein. Charcoal at night.
- No b6 (but can add p5p). I don't know what to do with this so I am leaving it off my list.
- I have a PEMT (+/+) and it says that this means I have trouble creating choline. Should I take choline?
Sources: AMRI Heartfixer
Snps interpretation guide by caledonia
Wow you read to the bottom. Thanks. I appreciate it!!
Sleepingbeautycan (I think I can I think I can)