@Hip 's $40 setup seems to be fine for the transdermal method. But it seems to me that this transdermal method, while relatively safe with just 3 gamma and nitrogen-risk-free, will have limited effect on pathogens. Therapeutic gamma per treatment is in the 30-60 range in up to 80 CC doses. Gamma can go as high as 80 (but should never exceed that). At these levels, you will most certainly will feel things happening to your body.
I have never tried any ozone therapy other than my transdermal ozone water method, so unfortunately I cannot compare its efficacy (in terms of my subjective sense of how it helps my symptoms) to other methods. I came up with my transdermal method after hearing about ozone gas applied via a body bag that covers you whole body, and hoped that transdermal ozonated water would get similar results as a body bag.
But if anyone like yourself that has experience with other methods would like to try this transdermal ozone water approach, then you would be in a position to subjectively judge its efficacy against other methods.
It would certainly be much cheaper and much more convenient to administer ozone at home by this transdermal method.
Note also that that in ozone autohemotherapy, although you are applying 80 gamma ozone to around 100 ml of blood extracted from the body, there are around 50 liters of water in the body in total, so once this treated blood is returned to the body, the ozone in it gets diluted down by a factor of 50,000 / 100 = 500 times.
The ozone has done wonders. In the day leading up to my first treatment I couldn't sleep, was in miserable pain, and was expecting to die very soon. I was at rock bottom. Zero %. The ozone made a difference by the second treatment and I've improved tremendously ever since. A few days ago I felt as good as 90% back to normal. I was able to smile, joke around with my wife, whistle songs, and get back to my good old chipper form.
Or did ozone not make much overall improvement to your ME/CFS, but just helped particular symptoms such as pain or sleep?
Ozone helps kill the organisms (fungal and bacterial) that are roaming around my blood vessels, but it cannot penetrate into tissues with poor blood supplies (like infected bone) to kill the source infection sites.
It's possible that ozone might stimulate the immune system in a way that helps fight pathogens; that however is an indirect means of killing pathogens. But ozone may offer other benefits not related to pathogens.