Hymecromone- new substance to suppress neuroinflammation

[Hufsamor]

https://www.eurekalert.org/pub_rele...rmKySurleeeDYfeOGgrk2M6H9nHqMmUMW8KBFDxzDcS_w

Biologists from RUDN University confirmed that a well-known spasmolytic drug called hymecromone can suppress the inflammatory response in astrocytes, important glial cells of the central nervous system. Potentially, it could be used to develop medications against Alzheimer's disease and other neurodegenerative conditions.

 

[Hufsamor]

Hymecromone turned out to suppress the production of anti-inflammatory molecules: tumor necrosis factor α and interleukins IL-6 and IL-1β, as well as oxylipins. At the same time, it increased the development of IL-10 that helps stop the inflammation. Having measured the levels of hyaluronic acid, the team confirmed that astrocytes actively produced this substance in response to liposaccharides. However, when a cell culture at the initial stages of the immune response was treated with hymecromone, the levels of hyaluronic acid dropped down. At the same time, hymecromone failed to have the same effect on the cells that did not inflame after contact with the liposaccharide. In these cultures, astrocytes continued to produce hyaluronic acid in regular quantities.
According to the biologists, it is still early to say for sure that the anti-inflammatory properties of hymecromone are rooted in its ability to reduce the production of hyaluronic acid. Still, the team is positive that these processes are connected.
"We managed to confirm that hymecromone is a promising compound that can be used to treat neuroinflammation. The mechanisms of its anti-inflammatory activity require further studies but given that this drug is widely used in clinical practice, the possibilities of such research are vast. Its efficiency can be safely tested when treating many pathologies that require inflammatory response suppression," added Dmitry Chistyakov from RUDN University.

 

[andyguitar]

Well done @Hufsamor in finding that, it's very interesting!

 

[andyguitar]

Hymecromone is also also called 4-MU. Comes from Coumarin which is found in Chamomile and Lovage. Little bit about it here.......

 

[Wolfcub]

Thank you @Hufsamor This is a good find!

And @andyguitar .....Lovage and Camomile tea here I come.....

 

[Rufous McKinney]

And @andyguitar .....Lovage and Camomile tea here I come.....

good reminder: get some chamomile (it is delightful)

 

[raghav]

It says hymecromone is used in bile therapy. It is used as choleretic. How do we get it ?

 

[andyguitar]

It says hymecromone is used in bile therapy. It is used as choleretic. How do we get it ?

Looks like it's available as a supplement. Says so here......

 

[andyguitar]

It says hymecromone is used in bile therapy. It is used as choleretic. How do we get it ?

In France it goes under the brand name "Cantabiline". Have you heard of it @pattismith ?

 

[pattismith]

In France it goes under the brand name "Cantabiline". Have you heard of it @pattismith ?

yes, it's seems available here, I will get it and give it a try

 

[raghav]

Any update @pattismith

 

[pattismith]

Any update @pattismith

yes, I took it a few days (three tablets a day), but unfortunately couldn't tolerate it because of digestive side effects...

 

[raghav]

Hard luck @pattismith