How the UK found the first effective Covid-19 treatment — and saved a million lives

Alvin2

The good news is patients don't die the bad news..
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How the UK found the first effective Covid-19 treatment — and saved a million lives

The United Kingdom is not a pandemic success story. But its massive Covid-19 trials program is.


As the coronavirus pandemic exploded across the world, medical science was starting from scratch. While the long-range goal was an effective vaccine, millions could — and would — die before a shot was approved and widely distributed. The best bet for preventing as many deaths as possible was to find existing drugs that could treat Covid-19.


But doing this would require enormous capacity: Researchers had to test a lot of different therapies simultaneously, which would mean recruiting thousands of patients to participate. In the US, the New York Times’s Carl Zimmer wrote in January 2021: “many trials for Covid antivirals were doomed from the start — too small and poorly designed to provide useful data.”


The United Kingdom’s Recovery Trial was the opposite: massive and simple. It has proven to be the most effective program in the world for delivering desperately needed research results. Pharmaceutical companies sought out partnerships with the Recovery Trial because they see it as the most reliable way to determine whether their drugs can help stop the global outbreak. Since June 2020, when Horby and Landray saw the first results on dexamethasone, the trial has since identified another drug, tocilizumab, that improves mortality rates. It has also done the valuable service of demonstrating that some once-promising treatment candidates don’t work.
Warning, this is a long article
https://www.vox.com/22397833/dexamethasone-coronavirus-uk-recovery-trial
 

nerd

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The article doesn't mention if they tried Ivermectin as well. Tocilizumab isn't effective in the replication phase, so what do you give patients early so that they don't even end up in the hospital?

They weren't the first ones seeing results on dexamethasone. They just had the largest trial. Assuming they still used a negligible dosage of dexamethasone and compared it with a potent dosage of Tocilizumab, I'm not surprised they found that Tocilizumab works better. If you design studies this way that you take a potent dosage of one drug and a less potent dosage of another drug, you easily predetermine the outcome of the study.
 

Booble

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The article doesn't mention if they tried Ivermectin as well. Tocilizumab isn't effective in the replication phase, so what do you give patients early so that they don't even end up in the hospital?

They weren't the first ones seeing results on dexamethasone. They just had the largest trial. Assuming they still used a negligible dosage of dexamethasone and compared it with a potent dosage of Tocilizumab, I'm not surprised they found that Tocilizumab works better. If you design studies this way that you take a potent dosage of one drug and a less potent dosage of another drug, you easily predetermine the outcome of the study.
I think the article was focusing on the trial methodology not the actual medicines.
 
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But its massive Covid-19 trials program is.
I watched a Commercial- on You Tube, it appeared and it was a detailed long story on how Pfizer developed their vaccine.

I was really impressed- watching this. It was compelling, the people working there are heroic. Many never saw their own families for the entire time- they sacrificed alot so that they could possibly save humanity.
 
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How the UK found the first effective Covid-19 treatment — and saved a million lives

The United Kingdom is not a pandemic success story. But its massive Covid-19 trials program is.



Warning, this is a long article
https://www.vox.com/22397833/dexamethasone-coronavirus-uk-recovery-trial
The US doctors from the Covid -19 Critical Care Alliance were calling for cortico steroids to be used well before the Recovery trial. Dr.Pierre Kory testified before the US Senate in May 2020 about the urgent need for steroids to treat patients and he received a hostile reaction from media and medical bodies across the world. As Dr.Kory points out the UK Recovery Trial used a low dose of dexamethasone when the dosage should be higher and instead a much better steroid should be used Methylprednislone.
 

Hip

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The UK's Antiviral Taskforce is aiming to have drugs available by this autumn that people can take at home at the first signs of a coronavirus infection, which will be effective enough to prevent the illness turning serious and requiring hospital treatment.

The taskforce will probably focus on monoclonal antibody-based drugs.
 
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MODERATOR'S NOTE: SEVERAL OF THE POSTS IN THIS THREAD WERE OFF-TOPIC, AND HAVE BEEN MOVED TO 'EFFECT OF IVERMECTIN ON COVID-19 INFECTION AND MORTALITY.'

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