How much is your Mean Platelet Volume? MPV correlates with hypoxia

[pattismith]

 

[pattismith]

My MPV is above 13 and the upper limit for my lab is 10

 

[Nine lives]

My lab ranges are (7.5-12.5) - I have a Sept 2020 reading of 12.1 and May 2021 of 11.8. All technically in range but toward top end.(I do not have PDW measurements).

 

[dylemmaz]

i have had elevated mean platelet volume in every one of my labs (10+ draws since being sick). i have asked doctors multiple times what it could mean, but i am never taken seriously.

i also have clear evidence of tissue hypoxia. my central venous oxygen saturation was very low (36%) when i was experiencing a severe episode of PEM.

my red blood cell distribution width has been consistently low, as well. something weird is happening with my blood.

i am waiting on a referral to a hematologist to address these things, but alas i expect to be dismissed

 

[pattismith]

@dylemmaz

high MPV is normal if you have some bleeding disorder. Once you have rule out any bleeding, high MPV means activated platelets: It can be related to hypoxia or inflammation or diabetes;

Do you have classic inflammatory markers?

If you don't have these markers, if you don't have diabetes, then you have to look for chronic or intermittent hypoxia.

Chronic hypoxia can happen with breathing obstruction for example.

Intermittent hypoxia can happen with bradypnea/hypopnea/apnea.

Do you have high bicarbonates in your blood (I mean bicarbonates close to the upper limit?)

 

[dylemmaz]

@dylemmaz

high MPV is normal if you have some bleeding disorder. Once you have rule out any bleeding, high MPV means activated platelets: It can be related to hypoxia or inflammation or diabetes;

Do you have classic inflammatory markers?

If you don't have these markers, if you don't have diabetes, then you have to look for chronic or intermittent hypoxia.

Chronic hypoxia can happen with breathing obstruction for example.

Intermittent hypoxia can happen with bradypnea/hypopnea/apnea.

Do you have high bicarbonates in your blood (I mean bicarbonates close to the upper limit?)

my ESR and CRP are completely normal. no signs of an inflammatory condition. my tumor necrosis factor is elevated however, not sure if that’s sensitive enough as an inflammatory marker

no diabetes. i also don’t believe i have breathing obstruction. i’ve had many x-rays and ct scans of my chest that were all normal. no lung function testing however, but i’m not sure anything would show there (never suffered with any symptoms that would lead me to pursue this avenue).

my carbon dioxide level is normal in every lab. pretty sure all bicarbonate testing has been normal (not even high normal)

 

[pattismith]

my carbon dioxide level is normal in every lab. pretty sure all bicarbonate testing has been normal (not even high normal)

You had carbon dioxide from venous or arterial blood?

 

[bob800]

My MPV is 12.1. Platelets 183 tho/uL. Normal ESR / CRP.

 

[pattismith]

interestingly, they also found higher MPV in patient with orthostatic intolerance and found it correlated with sympathetic activation. (but orthostatic intolerance also correlates with some degree of brain hypoxia to my understanding).

Art. 1.1475/ringraziamenti (europeanreview.org)

In another study in Fibro patients, they found negative correlation between vitamin D status and MPV.

(note that low iron and low vitamin D are frequent in inflammatory bowel diseases)

Relationship between mean platelet volume and vitamin D deficiency in fibromyalgia | Request PDF (researchgate.net)

 

[Learner1]

MPV has ranged from 8.9 to 11.4 over past 4 years. No correlation with symptoms including POTS, inflammation markers, HBOT usage, and I'm not vitamin D deficient.