LMAO! Seriously, that gave me a hearty, well-needed chuckle.
HOT! Coffin, Sharma, and Goff@ Conference on Retroviral Infections...
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Well, I don't like cruelty to animals. However, a test they might have employed to see if the monkeys were sick, would be an exercise test such as the Lights did, to check for post exertional maiaise indicators. Of course, with animals, they would push them harder, like the test done on lab mice re the results when they exercised to exhaustion.
Sing
Sing
I've had "exercise intolerance" as a google alert for a long time. There is rarely an alert for humans. Maybe most clinicians and researchers think that it's impossible for humans to have exercise intolerance, and if the humans would just practice GET...
But exercise intolerance alerts for animals are fairly common. Veterinarians don't think twice about diagnosing an animal with exercise intolerance. They don't even have to test the animals or force them to exercise; apparently they can just observe the intolerance. (They don't even have to ask the animals to fill out questionnaires.)
So I, too, am hoping that the Emory researchers collected some exercise data on the monkeys they infected with XMRV.
But exercise intolerance alerts for animals are fairly common. Veterinarians don't think twice about diagnosing an animal with exercise intolerance. They don't even have to test the animals or force them to exercise; apparently they can just observe the intolerance. (They don't even have to ask the animals to fill out questionnaires.)
So I, too, am hoping that the Emory researchers collected some exercise data on the monkeys they infected with XMRV.
G
UMMM, actually I think, according to these papers that all the monkeys are dead. They had four males and 1 female. Females are more expensive than males so they were pretty serious about this study. If Abbot Labs does another infection on an additional set of monkeys then you can take that as real excitement from the Pharma people. (grins) They don't infect those monkeys with just anything!
( I live a few miles from a monkey lab where my neighbor use to work taking care of them)
( I live a few miles from a monkey lab where my neighbor use to work taking care of them)
A
Well, their VO2 Max is going to suck, then.
I believe (and hope) this was so. I too know people who work with animals in research and they do observe them carefully. The center I know of socializes its primates - i.e. they get playtime in a large area with other primates so if these animals were sick, they might observe something then. I think these researchers were more interested in prostate cancer since they chose mostly male animals but I'll take whatever results we can get.
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It appears these animal experiments were done before the Science paper came out. So were they were just investigating the virus without regard to CFS? Or did they know about it beforehand (unlikely due to scientific embargo)?
I'm crying about the monkeys. 
I was okay about it before but I feel so sad now. Wasn't there any other way for them to study XMRV?
I was okay about it before but I feel so sad now. Wasn't there any other way for them to study XMRV?
Retrovirology Conference Webcasts
Apologies if this has already been posted, but I don't remember seeing anyone post a link to the actual retrovirology conference webcasts:
http://www.retroconference.org/2010/data/files/webcast_2010.htm
The webcasts are divided by day (Tue, Wed, Thu, Fri). If you click on Friday the main talk of interest is by Stephen Goff entitled "Mouse to Man? XMRV and Human Disease"
Let me know if there are any other good talks in there.
Apologies if this has already been posted, but I don't remember seeing anyone post a link to the actual retrovirology conference webcasts:
http://www.retroconference.org/2010/data/files/webcast_2010.htm
The webcasts are divided by day (Tue, Wed, Thu, Fri). If you click on Friday the main talk of interest is by Stephen Goff entitled "Mouse to Man? XMRV and Human Disease"
Let me know if there are any other good talks in there.
Here are some more direct links to XMRV talks:
Prevalence of Xenotropic Murine Leukemia Virus in Prostate Cancer - Walid Heneine
XMRV: Examination of Viral Kinetics, Tissue Tropism, and Serological Markers of Infection - John Hackett
Cellular Determinants Required for Infection of XMRV, a Novel Retrovirus Associated with Human Familial Prostate Cancer - Hinh Ly
Organ and Cell Lineage Dissemination of XMRV in Rhesus Macaques during Acute and Chronic Infection - Prachi Sharma
Host Regulation of XMRV in Prostate Cancer - Robert Silverman
Prevalence of Xenotropic Murine Leukemia Virus in Prostate Cancer - Walid Heneine
XMRV: Examination of Viral Kinetics, Tissue Tropism, and Serological Markers of Infection - John Hackett
Cellular Determinants Required for Infection of XMRV, a Novel Retrovirus Associated with Human Familial Prostate Cancer - Hinh Ly
Organ and Cell Lineage Dissemination of XMRV in Rhesus Macaques during Acute and Chronic Infection - Prachi Sharma
Host Regulation of XMRV in Prostate Cancer - Robert Silverman
G
Hi Garcia .
I have seen the conference XMRV lives most of its life in our DNA and can be inherited.it is very real.Only recently jumped from mouse.can infect any mammal with XRM1 receptor It needs its tail to replicate essentially a region called U3 and there is a small part of U3 called the GRE sequence that is vital for ita replication.The science looks really good as you would expect.It is one hell of a mother to find if there is anything else you want to know I,ll feed it through
I have seen the conference XMRV lives most of its life in our DNA and can be inherited.it is very real.Only recently jumped from mouse.can infect any mammal with XRM1 receptor It needs its tail to replicate essentially a region called U3 and there is a small part of U3 called the GRE sequence that is vital for ita replication.The science looks really good as you would expect.It is one hell of a mother to find if there is anything else you want to know I,ll feed it through
G
Hi Garcia .
I have seen the conference XMRV lives most of its life in our DNA and can be inherited.it is very real.Only recently jumped from mouse.can infect any mammal with XRM1 receptor It needs its tail to replicate essentially a region called U3 and there is a small part of U3 called the GRE sequence that is vital for ita replication.The science looks really good as you would expect.It is one hell of a mother to find if there is anything else you want to know I,ll feed it through
I have seen the conference XMRV lives most of its life in our DNA and can be inherited.it is very real.Only recently jumped from mouse.can infect any mammal with XRM1 receptor It needs its tail to replicate essentially a region called U3 and there is a small part of U3 called the GRE sequence that is vital for ita replication.The science looks really good as you would expect.It is one hell of a mother to find if there is anything else you want to know I,ll feed it through
Prof Ly's presentation showed that actually prostate epithalial cells were infected although didn't express this receptor! They are looking at alternative receptors/ways of entry as we speak. (My bet is on the CCR2 and/or CCR5 watch this space)
Abbot's lab guy presentation was fascinating in that they could only detect antibodies in 3 or 4 samples out of nearly 900 (ok healthy blood donors, but still....). Means what? it is present in much less than 4%, or even 1%? or that antibodies are produced only periodically, or not at all... or?
watch this space)Abbot's lab guy presentation was fascinating in that they could only detect antibodies in 3 or 4 samples out of nearly 900 (ok healthy blood donors, but still....). Means what? it is present in much less than 4%, or even 1%? or that antibodies are produced only periodically, or not at all... or?
To me this is alarming...we already no how many people are testing positive on this forum alone, and its a lot!! So this is a CFS illness!
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I had pain in my groin too at the early stages of ME diagnosis and illness, hurt the most when i was ill. I told my hospital consultant this around 1995, Not sure if it means anything, easy to pick out the bits that seem to fit, but at least worth mentioning, just incase patterns do happen. Interesting about the reproductive infection, and groin involvement when ill though isnt it ? also seemed somewhat enlarged i remember.
Still waiting for the UK wpi study to start. to know if im positive or not
Still waiting for the UK wpi study to start. to know if im positive or not
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Groin pain may represent 'chronic pelvic pain syndrome' - or interstitial cystitis, which may overlap with the former. I had this. At times I had pain from my knees up to my mid-back, plus I had to go to the bathroom 2x an hour. I am cured of it thanks to the Wise & Anderson approach developed at Stanford.