High Heartrate and anxiety after folic acid and Hydroxy-B12 Injections

[Ricahrd777]

Hello,
I had low folic acid (4.63) and low B12 (315) Holo TC (58.1).
My cfs doc told me to take 5mg of folic acid which i didnt do for obvious reasons.
I started with 400 mcg and went to 800 mcg. Yes i am talking about folic acid.
Then I injected 4000 mcg of Hydroxy-B12 over the course of 2 weeks.
My B12 is at 1500+.
The folic acid has been helping me a lot with anxiety.
Now I have A high heart rate (120 resting) and anxiety.
I tried Magnesium, it helps but I crash from it.
I cant tell whether Potassium is helping but I have been taking 4x750 mg of potassium a day and nothing changed, I also drink 2 liters of orange juice per day (for the last 3 years).
Interestingly, my folic acid dropped even further after B12 injections to 3 which doesnt make any sense since I have been taking 800 mcg for 2 weeks prior to the blood work. My anemia also improved on folic acid so it makes even less sense.
Does B12 lower folic acid?
What do I do?
Blessings,
Richard

 

[linusbert]

b12 kickstarting methylation, your demand on folate increasing. can make a lot of sense, actually i would have expected this.
so you actually might need much more, so why not take the 5mg?

did you doc measure homocystein? thats related to b12 and folate.

if you fear the folic acid, you can take folinic acid. its also not methylated , just spares a required enzyme in metabolic processing.
the other thing you can try is methylfolate. but i would go slow as it can lead to a methylation block.

as b12 is putting demands on methylation, i would consider taking stuff which aides with this, this can be cholin for example from egg yolks.
or betain.

also b6 and biotin are tightly related to this processes. you might want to take those too , biotin in higher dose like 1mg+. also b2 might be.
you also should take a whole b complex with all vitamins in daily RDA range.


this is a case study of a similiar topic, talking about the stuff i talked above:
"B12 damaged by nitrous oxide require megadosed folic acid rather than normal levels of folate?"

a few videos regarding this topic:

"Methylation, MTHFR, and Histamine with Chris Masterjohn, PhD"

"Does Methylfolate Make You Angry or Depressed? | Chris Masterjohn Lite #96"

"Sometimes Synthetic Folic Acid is Better Than Natural Food Folate | Chris Masterjohn Lite"

 

[Ricahrd777]

b12 kickstarting methylation, your demand on folate increasing. can make a lot of sense, actually i would have expected this.
so you actually might need much more, so why not take the 5mg?

did you doc measure homocystein? thats related to b12 and folate.

if you fear the folic acid, you can take folinic acid. its also not methylated , just spares a required enzyme in metabolic processing.
the other thing you can try is methylfolate. but i would go slow as it can lead to a methylation block.

as b12 is putting demands on methylation, i would consider taking stuff which aides with this, this can be cholin for example from egg yolks.
or betain.

also b6 and biotin are tightly related to this processes. you might want to take those too , biotin in higher dose like 1mg+. also b2 might be.
you also should take a whole b complex with all vitamins in daily RDA range.


this is a case study of a similiar topic, talking about the stuff i talked above:
"B12 damaged by nitrous oxide require megadosed folic acid rather than normal levels of folate?"

a few videos regarding this topic:

"Methylation, MTHFR, and Histamine with Chris Masterjohn, PhD"

"Does Methylfolate Make You Angry or Depressed? | Chris Masterjohn Lite #96"

"Sometimes Synthetic Folic Acid is Better Than Natural Food Folate | Chris Masterjohn Lite"

Thanks a lot. But what about the heart rate? I guess i need more potassium then?

 

[linusbert]

i dont know, there are a lot of reasons for this.
and it mustnt be just potassium. it can be though.

it can be also any electrolyte imbalance. like sodium, calcium, phosphor.
or anemia.
didnt your doc take the blood work?

maybe check back with your doc and get a full electrolyte panel and also check the homocystein.

we also have methylation threads in this forum, and about refeeding i would check those.
there is freddd's methylation protocoll, its quite sophisticated. or the simple methylation protocol.
you really should read into that.

 

[JES]

When you face a problem from a supplement, adding more of another supplement is very risky in my opinion. I tried this a few times and failed as the biochemistry is way too complicated to predict the response especially when you start "compensating" for one supplement with another.

The only safe solution IMO is to lower the dose of the supplement that you think is causing your anxiety and high heart rate. In my case I never got around the anxiety from B12, folate and certain other B-vitamins despite trying them several times in combination and individually.

Did you get blood tests done for B12 and folate?

 

[Ricahrd777]

When you face a problem from a supplement, adding more of another supplement is very risky in my opinion. I tried this a few times and failed as the biochemistry is way too complicated to predict the response especially when you start "compensating" for one supplement with another.

The only safe solution IMO is to lower the dose of the supplement that you think is causing your anxiety and high heart rate. In my case I never got around the anxiety from B12, folate and certain other B-vitamins despite trying them several times in combination and individually.

Did you get blood tests done for B12 and folate?

Unfortunately I already injected the B12. No recent bloodwork no.

 

[Judee]

I don't know if it would be helpful but at one point we had a doctor from Italy join just so he could post in some of the methylation threads.

I don't think he's on the site anymore but these are his listings: https://forums.phoenixrising.me/members/bodymindspirit77.37961/#recent-content

I would go back to the earliest ones on page 2.

IIRC he thought that we should take the folate daily but the b12 only once in a while because it stores in the body for a long time. ??? IDK.

I believe Post #9 here is where he made some suggestions to the OP of that thread: https://forums.phoenixrising.me/thr...working-cant-find-the-missing-cofactor.76310/ but I still would go back and read some of his earlier posts where he explains his reasoning more.

He also recommended in one of those threads (and I've heard this from a YT doctor as well) that a person should treat the SIBO (if they have that) first before doing methylation. The YT doctor said that's because SIBO bacteria also use methylation, taking the supplements (orally) will just basically fertilize them. (I wonder if that's why so many get anxiety from it. Again, IDK. I'm sorry.)

Anyway, hope this helps somehow.
(I also agree with JES' recommendations.)

 

[Ricahrd777]

I don't know if it would be helpful but at one point we had a doctor from Italy join just so he could post in some of the methylation threads.

I don't think he's on the site anymore but these are his listings: https://forums.phoenixrising.me/members/bodymindspirit77.37961/#recent-content

I would go back to the earliest ones on page 2.

IIRC he thought that we should take the folate daily but the b12 only once in a while because it stores in the body for a long time. ??? IDK.

I believe Post #9 here is where he made some suggestions to the OP of that thread: https://forums.phoenixrising.me/thr...working-cant-find-the-missing-cofactor.76310/ but I still would go back and read some of his earlier posts where he explains his reasoning more.

He also recommended in one of those threads (and I've heard this from a YT doctor as well) that a person should treat the SIBO (if they have that) first before doing methylation. The YT doctor said that's because SIBO bacteria also use methylation, taking the supplements (orally) will just basically fertilize them. (I wonder if that's why so many get anxiety from it. Again, IDK. I'm sorry.)

Anyway, hope this helps somehow.
(I also agree with JES' recommendations.)

So what about the high heart rate? thats my main symptom

 

[Judee]

Idea 1: In that one thread after Post #9 he went on to say we underestimate the importance of Riboflavin in these protocols.

Idea 2: Also many of the threads on methylation mention the importance of Potassium and that being very much depleted by B12 treatment. (V8 or a similar food solution seems safer to me than than popping potassium pills though. It's probably too easy to go back the opposite direction and get bradycardia with pills. ??)

You can search for posts by Freddd as well as Tina (Though I can't remember her full user name. @linusbert might.) She was also have a hard time with anxiety (and I believe high heartrate). ???

Idea 3: Again the SIBO. If you're possibly increasing bad bacteria I could see where it would have that affect on a person similar to how a person gets high heart rate when they have an infection.

 

[linusbert]

You can search for posts by Freddd as well as Tina (Though I can't remember her full user name. @linusbert might.) She was also have a hard time with anxiety (and I believe high heartrate). ???

@TinaT was her name, but she hasnt been here since may. dont know how her case developed or if she figured it out.