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High blood level of vitamin b6

Messages
10
Hello,

after a recent blood test, my Vitamin B6 levels came out really high:
Vitamin B6 (Pyridoxal) 228 nmol/L (Ref. Range: 20 - 121)

I never took much B6, only what's in the Thorne Research Stress B-Complex:
Vitamin B6 25 mg (Pyridoxine HCL) and 3,4 mg (P-5-P)

Should i switch to the only active form? Or completly ditch the B6?

Thank you.
 

YippeeKi YOW !!

Senior Member
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16,064
Location
Second star to the right ...
Should i switch to the only active form? Or completly ditch the B6?
Hi @hberg ....
For some reason a lot of us in these threads are reactive to B vits, in varying degrees of severity.

I finally just gave up and cut all B-vits out of my supplements entirely, except for the small amounts in my multi which I could just barely tolerate, and substituted desiccated liver caps, which are high in a lot of critical vitamins, including B's. I've only recently (about 3 years or so after dropping them out of rotation) started thinking about adding back very small amounts of B-12 and Folate, but haven't worked up my courage yet.

There's a lot of info posted by @Freddd about SNPS, genetic mutations, and other info revolving around B vits and methylation. If you go up to the 'Search' button at the top right of every page (in the dark blue band across the top of all pages) and enter Freddd's user name, or even just 'B-vitamins', you'll probably find several hundred posts.

In the meantime, you might want to go with whatever your gut is telling you. You may have to forego B vits for awhile, if they really make you feel rough, but who knows? We're all so different in our reactions to this dismal little dump-truck of an illness that there's no one-size-fits-all.


I know there are tons of people on these threads who know a lot about this, and am hoping they'll be posting here for you :):) :thumbsup: ....
 

LINE

Senior Member
Messages
862
Location
USA
I have a CFS friend who did blood tests for B12/Folate and tested quite high. She stopped them but then reverted back to symptoms such as tingling. She is going back on the B12/Folate. YippeeKi brings up some interesting points. There is obvious dysregulated responses in the ME patient, so anything goes.

One thing I have thought about is that perhaps the b vitamins are not reaching inside the cell so it spills out in the blood thus the high levels. High triglycerides are an example, does this happen because there is too much bad fats consumed or that the triglycerides are not being burned as energy? The first example is the most common thought (caused by too many bad fats, or genetic etc) while the second idea is not thought about.

Dr. Majid Ali is a ME doctor and quite an informed one, he states that he gives IVs of magnesium and potassium and brought up a good point where he defined something called "leaky Cell syndrome". The idea is that the cell membranes are damaged and can not retain the magnesium and potassium. The cells are damaged via oxidative stress.
 
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YippeeKi YOW !!

Senior Member
Messages
16,064
Location
Second star to the right ...
One thing I have thought about is that perhaps the b vitamins are not reaching inside the cell so it spills out in the blood thus the high levels. High triglycerides are an example, does this happen because because there is too much bad fats consumed or that the triglycerides are not being burned as energy? The first example is common thought while the second
Interesting hypothesis, and at least to me, it feels right on ....

Could you maybe add what was left out after "The first example is common thought while the second ......"

I'm on tenterhooks about what " ....the second ...." is :nervous::nervous::nervous: :jaw-drop::jaw-drop: :):).....
 

LINE

Senior Member
Messages
862
Location
USA
Interesting hypothesis, and at least to me, it feels right on ....

Could you maybe add what was left out after "The first example is common thought while the second ......"

I'm on tenterhooks about what " ....the second ...." is :nervous::nervous::nervous: :jaw-drop::jaw-drop: :):).....

Oh, a ME moment :) Let me know if I need to clarify.

One thing I have thought about is that perhaps the b vitamins are not reaching inside the cell so it spills out in the blood thus the high levels. High triglycerides are an example, does this happen because there is too much bad fats consumed or that the triglycerides are not being burned as energy? The first example is the most common thought (caused by too many bad fats, or genetic etc) while the second idea is not thought about.
 

LINE

Senior Member
Messages
862
Location
USA
Dr. Majid Ali is a ME doctor and quite an informed one, he states that he gives IVs of magnesium and potassium and brought up a good point where he defined something called "leaky Cell syndrome". The idea is that the cell membranes are damaged and can not retain the magnesium and potassium. The cells are damaged via oxidative stress.

If I may add something to the above comment. Some researchers such as Patricia Kane believe that supplying fats will help repair the cell membrane, when the cell membrane has integrity, the cells behave correctly.

There are a number of ideas which fats will help including phosphatidylcholine which I used. There are varying amounts of PC in different products. I use sunflower lecithin (not lecithin from soy). Others have claimed that other healthy oils have helped as well. Antioxidants help protect the cell membranes from oxidative stress, I am a big fan of natural vitamin E* and also use full spectrums such as Vitamin C, polyphenols etc.

*α-Tocopherol, Vitamin E, is an important lipid peroxidation antioxidant found in cell membranes. It acts as an antioxidant by donating a hydrogen atom to a lipid-peroxyl radical.
www.sigmaaldrich.com/life-science/cell-culture/learning-center/media-expert/vitamin-e.html
 
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