Hesperidin Methyl Chalcone: potent neuro-anti-inflammatory and pain relief.


Senior Member
I’ve been trialling Doctor’s Best Hesperidin Methyl Chalcone (HMC) on and off more than a month. This product is remarkably potent against brain fog and neck pain, in fact I’d say HMC is as effective as naltrexone for me (which I use concurrently). HMC is by far the most impressive supplement I’ve tried. I’m hoping it proves helpful for other members too. Chalcone derivatives could prove useful in ME/CFS, I really hope more options become available.

What is Hesperidin Methyl Chalcone?
Hesperidin is a flavone found in citrus fruit, on its’ own has had no reported benefit on PR. However, as a ‘chalcone methylated derivative’ it possibly has enhanced anti-inflammatory potential that appears ideal for ME/CFS. There is another product, Cyclo 3 Fort, containing Ruscus aculeatus, hesperidin-methyl-chalcone and ascorbic acid, which is prescribed for chronic venous disease in Europe.

The science of Chalcone Derivatives
A number of natural and (semi-) synthetic chalcone derivatives have demonstrated admirable anti-inflammatory activity due to their inhibitory potential against various therapeutic targets like Cyclooxygenase (COX), Lipooxygenase (LOX), Interleukins (IL), Prostaglandins (PGs), Nitric Oxide Synthase (NOS), Leukotriene D4 (LTD4), Nuclear Factor-κB (NF- κB), Intracellular Cell Adhesion Molecule-1 (ICAM-1), Vascular Cell Adhesion Molecule-1 (VCAM-1), Monocyte Chemoattractant Protein-1 (MCP-1) and TLR4/MD-2, etc.
Read here: eurekaselect.com/155594/article

[Chalcones and their] significance as antidiabetic, anticancer, anti-inflammatory, antimicrobial, antioxidant, antiparasitic, psychoactive, and neuroprotective agents.
Read here: frontiersin.org/articles

Hesperidin Methyl Chalcone in research:
HMC protects against metabolic syndrome [1]
HMC inhibits joint pain and inflammation via NFkB [2]
HMC enhances cartilage tissue repair [3]
HMC protects against inflammation and pain in mice (TRPV1, OS, NFkB) [4]
Hesperidin as a neuroprotective [5] [6]

How to use HMC (and avoid the side effects):
  • Take single dose 250mg – 500mg with breakfast (feel effect within 30-45min). Note: taken without food may cause abdominal pain or discomfort, and any later dose may likely cause insomnia.
  • HMC comes as 500mg. Personally, I think 250mg – 300mg is as good, certainly good to start with.
  • HMC may cause stomach pain on day 3-4, if so suspend using for 2 days then resume, pain should not recur.
  • HMC didn’t interact well with CBD Oil for me. HMC taken morning and CBD at night is OK, but even then, I would overheat at night. Strange interaction with CBD Oil for me.
  • HMC may warrant caution with meds for blood pressure, thinners and cholinesterase inhibitors.
  • HMC seems to last 24 hours, maybe more depending on dosage. Effectiveness is reduced ~30% with continuous use, maybe experiment with pulsing (eg. day-on day-off, or 5 days-on 2-off, etc).

The noted side effects of HMC are abdominal pain, diarrhea, gastritis.
I got abdominal pain day 3 or 4, but this did not recur after a two-day suspension. I did not get diarrhea and I didn’t aggravate the gastritis I have had with ME.

HMC is relatively cheap and worth a try, available at iHerb, Amazon and Douglas Labs. If you do try HMC, could you please report your experience on this thread to help other members learn how this product worked for you, thanks.
Thanks for posting about this. I took 500mg daily with breakfast for a little over a month, and it didn't improve any of my symptoms. I didn't experience any side effects while I was on it. Hope more people find it helps them. :)
United Kingdom
Thanks for the reply. I've decided to stick with orovitoics and try lactoferrin instead. A forum member who's only on twitter now said she's still using it and it really helps her fatigue. So I'm gonna give that a go first as probiotics are helping me loads.