Heavy Brain fog and energy fluctuation - history of depression and anxiety

Santino

Senior Member
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209
The standard protocol (which find on the official LDN website) is start with 4.5mg (adults).

Other protocols I only find used from other doctors or patients who wrote about LDN...

hmm. I will look at some videos...


edit:

Yeah, I also found one who had to stop because he experienced manic symptoms on bipolar disorder. Although LDN worked well for all his conditions, he had to stop forever because it induced mania...

So yes...I should start low. I think I will start at 1,5 or 2mg for 2 weeks, then 3mg for 2 weeks and then 4.5.
 

Santino

Senior Member
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209
I feel like LDN is my last hope and at this moment the only alternative to drugs like immunesuppressants.

At this moment I eat a diet which I do not find healthy. Plus I feel the fluctuation of energy all the time because of carbohydrates. On the ketogenic diet I felt much more even and at peace. Now it is going up and down again. I have too much energy, then too less. Switching all the time.

And the "allergy"-Symptoms do not go away. I had the impression that my midday coffee today led to a flare up.

I have no idea what to do further. I see people jogging in the park and am frustated and afraid, that I never can be the "old" one, running through the park, lifting weights and doing fighting...

Please god, help me....
 

Gondwanaland

Senior Member
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5,105
Also, have you considered trying another form of magnesium? The citrate might have become detrimental to you.
 

Santino

Senior Member
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209
The problem with any product (probiotic, magnesium etc) is, that I am sensitive to nealry every filler. It have to be pure magnesium oxide and pure probiotics...

Maybe you know a product?! Ich found one which is in MCT oil and maybe I will try it (probiotic).

Do you use a pure powder? And what are the benefits of oxide? I alway read that this form is bad absorbed compared to other forms...

I tried a lot to get food which would act like resistant starch or are resistant starch: Bimuno, Lactulose, fodmaps, inulin, FOS.

They either trigger the allergy symptoms (bimuno and Lactulose) or they give me heavy brain fog, depression and constipation (inulin, FOS and fodmaps)
 

Gondwanaland

Senior Member
Messages
5,105
I use pure magnesium oxide powder - the oxide just becomes hydroxide or water. Sodium bicarbonate in foot baths also helped me with food intolerances. I found that just tiny bits of MgO and bicarbonate were very effective.

BUT such alkalizing interventions are known to trigger terrible candida flares in people dealing with this problem. It could also benefit other pathogens, who knows.

The best thing I found so far for my gut is dairy from the alps. Unfortunately I don't have access to it here where I live.

So now I am going to try another probiotic (from Japan) to raise Clostridium butyricum in my gut. I hope the customs in my country will not confiscate it.

There are also butyrate supplements, but one person reported an allergic reaction to it.

You can read more about it in the latest 5 pages of the topic I linked above and make up your mind.
 

Santino

Senior Member
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209
If you want to get butyrate, then eat Ghee self made from gras fed butter. This worked wonders for me. "Unfortunately" it is high in vitamin a and I get a reaction to it. Otherwise Ghee would be everyday food for me!

I guess there is no better probiotic or prebiotic than FMT done in Taymount clinic.

It would be money wasting for me to get tiny effects on my gut flora.

When it is fixed once, I hope that I can tolerate the resistant starch without having these allergy like symptoms...
 

Gondwanaland

Senior Member
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5,105
In the first page of this thread Brenda suggested, in addition to LDN, Magnesium L-Threonate, which could also be a good option.
 

Santino

Senior Member
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209
Citrate has really good bioavailability. But maybe I will try oxide once my citrate is used up...

I had diarrhea with blood this morning...since I cannot eat low carb/ketogenic (which is found to be best for IBD), my inflammation seems to come back. It was in remission always on the ketogenic diet...

At this moment, the LDN really is something like my last hope preventing me from typical western medicine (cortisone), which would treat my symptoms and make me sick long term...
 

Gondwanaland

Senior Member
Messages
5,105
I stopped it for 3 weeks and in principe all symptoms got worse....
I see 4 possibilities:

a) the citrate is becoming too acidic for you
b) the magnesium is inducing an electrolyte imbalance in relation to potassium, sodium, calcium
c) all of the above
d) none of the above
 

Santino

Senior Member
Messages
209
Why do you think that all this has something to do with magnesium?

By the way: Citrate is alkalic.

I feel very bad today. I woke up in the morning too early. Had diarrhea with bloody stool. I just can eat rice and chicken with flax seed oil.

The allergy symptoms are better now because I ate like this, but my gut flares up because I leaved out the probiotics.

I therefore took my probiotics a few minutes ago because I think better allergy symptoms than gut inflammation.

But this all leads no where...

I was by the rheumatologist and he found again my creatinine was too high although I don´t do any sport since 3 weeks.

Also one liver marker was little to high.

And last but not least he said that I would have a fatty liver which is unexplainable.

Ketogenic diet is used to treat fatty liver...

I have 2 options now:

Going to a clinic a maybe take cortisone...
Taking LDN on my own which I think is too risky because of my liver and renal markers....
 

Santino

Senior Member
Messages
209
interesting. But I lastly (2 weeks ago) checked minerals in blood (serum and cells) and my magnesium was precisely in optimal range. Calcium slighty too high. Selenium high deficient, zinc little deficient.

Today I am totally sick. Yesterday i took my probiotics again + GABA.

I think that had an allergic reaction to GABA. And this really would mean, that I develope MCS. Because GABA really is not comparable to Vitamin C etc. The only thing all these things have in common is that they are synthetic.

I don´t know why I then react to the vitamin C in food.

I really don´t know anything. Fact is that I either have really heavy reaction to my probiotics which I could take maybe 2 months without adverse reaction (there is amylase in it) or I have a heavy reaction to GABA, which I could take ca. 1.5 years without any adverse reaction...

That is crazy. I would say it is from the probiotics, but the reaction is so damn heavy that I have to think about GABA, as I took 2g yesterday (which is my max dose) The reaction is really so heavy that it cannot come just from the probiotics...
 

Gondwanaland

Senior Member
Messages
5,105
I don´t know why I then react to the vitamin C in food.
Foods high in vit C are usually high in histamines. Citrate = citric acid = histamine
The reaction is really so heavy that it cannot come just from the probiotics...
Many strains increase histamines.

There is a tipping point for histamines, after this point, you react heavily to minimal amounts. And MCS can be turned on.

I don't remember where I read that Saccharomyces boulardii reduces histamines, but I found out to be true when I took it.

Here is an study about Histamine and histamine intolerance:
http://ajcn.nutrition.org/content/85/5/1185.full.pdf

There is a huge amount of info on histamine intolerance, and probiotics here at the boards. For instance:
http://forums.phoenixrising.me/index.php?threads/rethinking-probiotics.24643/
 

Santino

Senior Member
Messages
209
Hi gond,

this reaction I have is definitively not histamine induced.

I have reaction to histamine but it is very different and never that heavy, even if I eat very high histmamine foods for 2 weeks. Also never that heavy if i eat histamine liberating foods.

This reaction I have is either allergic or something like MCS.

I understand that it is difficult for you to differentiate between my several reactions.

My histamine reaction is peanuts when compared to this "allergic" (or whatever) reaction.

Histamine leads to heat sensations at my chest, depression, flush, anxiety...And I only have this reaction when eating very high histamine foods or when eating after drinking alcohol. Long time ago I drank any alcohol...

best regards...
 

Gondwanaland

Senior Member
Messages
5,105
One thing is certain: you will have to try different things, because your current protocol is not working right now.

I can only say that when I had MCS oral magnesium oxide, transdermal sodium bicarbonate and Saccharomyces boulardii helped.

I think digestive enzymes could help you.

Calcium slighty too high. Selenium high deficient, zinc little deficient
  • Calcium is high because it has been mobilized by vit A and is also needed to neutralize histamines
  • Selenium is deficient because it is needed for glutathione (high amounts can convert too much T3 and be excitatory though)
  • I suppose a little zinc supplementation would also help
 
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