GSTP1 and Vitamin E

[Peyt]

Hi,
I am trying to figure out if I should take Vitamin E to help with my fatty liver and Preferal Nuropathy.
However, there seems to be some studies that says people with GSTP1 (either AG or GG) will have a negative effect when taking Vitamin E because it will increase inflammation. Study below:
https://www.snpedia.com/index.php/Rs1695

Now my question is: Does anyone know if this problem applies to both forms of Vitamin E (α-tocopherol and tocotrienol)?
The reason I ask is the study above was done with only the α-tocopherol, so I am wondering if the other form is okay, or at least there has not been any studies on it being a problem. Does anyone know if there is any information regarding increase in inflammation and usage of the tocotrienol form of Vit E?
Thanks so much,

 

[lenin]

Hi,

I can say that the only thing that has worked for me is vitamin E 400UI, dl-alfa-tocoferil acetato. It has reduced the pain in my legs a lot. I dont whether can cause more inflamation or not

 

[pamojja]

However, there seems to be some studies that says people with GSTP1 (either AG or GG) will have a negative effect when taking Vitamin E because it will increase inflammation

Most of these vitamin studies make the mistake of testing one nutrient in high doses in isolation. Especially with high alpha-tocopherol it is known that it reduces the other isomers of beta-, gamma-, and delta tocopherols. That alone could account for most negative effects of alpha-tocopherol supplementation. Or worse but very common, they even used the synthetic form of dl-alpha tocopherol. Therefore always best to also supplement the other tocopherols when supplementing natural l-alpha tocopherol.

I'm not aware of any study showing increased inflammation with yet another form of vitamin E, the tocotrienols.

 

[Peyt]

Especially with high alpha-tocopherol it is known that it reduces the other isomers of beta-, gamma-, and delta tocopherols. That alone could account for most negative effects of alpha-tocopherol supplementation.

Interesting, thanks