Genetic Genie Results. Any Help Would be Appreciated

[Murpcmnz]

Hi Guys,

Just got my 23andme results back. Any help or recommendations would be appreciated

Homozygous:

MAO A R297R
MTRR A664A

Heterozygous:

VDR Bsm
VDR Taq
MTRR A66G
BHMT-08
CBS C699T

Thanks

 

[Murpcmnz]

My homocysteine is high (13) but my MMA is low indication that my B12 is fine but it sounds like the MTRR indicates I need B12?

 

[Valentijn]

My homocysteine is high (13) but my MMA is low indication that my B12 is fine but it sounds like the MTRR indicates I need B12?

No, that MTRR variation has very little impact. Your SNPs listed here look quite normal.

Other MTRR and MTHFR mutations are listed at:
http://forums.phoenixrising.me/index.php?threads/interesting-mtrr-variations.24551/
http://forums.phoenixrising.me/index.php?threads/interesting-mthfr-variations.24543/

Typically only missense mutations will have a significant impact on function.

 

[Murpcmnz]

Thank you very much for your response. I had an HDRI panel done and waiting on those results but any speculation why homocysteine would be so high with mostly normal genes?

 

[Valentijn]

Thank you very much for your response. I had an HDRI panel done and waiting on those results but any speculation why homocysteine would be so high with mostly normal genes?

Avoiding meat and/or vegetables might cause low folate or B12, which I suppose might result in high homocysteine.

But there are also hundreds of other SNPs on the MTHFR gene and MTRR gene which are not tested by 23andMe - it's possible there is some dysfunction elsewhere on those genes.