Bloopy, These are from previous discussions in this same thread
More recent post
Remember that TMG is a big methyl so I'm not sure it would be wise to start that right off the bat and skip all the others. Caledonia and I have listed several basic things that most people seem to need. The methyls come later. As for Juniemarie adding yucca, or butyrate, or something else, this really depends on how sick you are, whether you need more gut support, and other factors. I don't see how those two would hurt though.
PLEASE READ: I guess the bottom line is that instead of adding in B-12 and methylfolate right away, its about getting the basics like B complex, digestive enzymes, antioxidants, some minerals, and stuff like that on board before you start methylation up. Usually, B-12 and methylfolate go together for best effects but the dosing is completely different for everyone. I know my doc likes injectables for people with MCS who can't tolerate B12 any other way but uses a variety of types for others. I don't know all that goes into her decision making but it sure is individualized.
First post about this from this thread
P5P isn't good right now cuz of the CBS, but maybe you could use low doses of 10mg
DMG shouldn't be used before TMG. You have to get the short route up and running with the BHMTs before you can fix the MTRR problem.
I'd say molyb sounds right and you need basic B vitamins and digestive enzymes to start. Then maybe a little hydroxy B 12 and vit c for free radicals. Then maybe some low dose SAMe to get rolling a little more. Unless your super type A and sympathetic dominant, niacin will just eat up more methyls so I'm not sure about even adding that one.
The goal is clean up not fixing the genes just yet. If you go after the genes first, you make more garbage. And when were sick, were already overflowing with garbage. This is the reason Yasko has so many foundation sups so there is a method to her madness although i don't think you need that whole list she gives. I think Caledonia may have some good input here. Remember that we dn't know who you are or what you've been thru or been exposed to so this changes things too. I would start low and go slow on some more benign stuff before your dumping in a bunch of methyls.
Remember that TMG is a big methyl so I'm not sure it would be wise to start that right off the bat and skip all the others. Caledonia and I have listed several basic things that most people seem to need. The methyls come later. As for Juniemarie adding yucca, or butyrate, or something else, this really depends on how sick you are, whether you need more gut support, and other factors. I don't see how those two would hurt though. I guess the bottom line is that instead of adding in B-12 and methylfolate right away, its about getting the basics like B complex, digestive enzymes, antioxidants, some minerals, and stuff like that on board before you start methylation up. Usually, B-12 and methylfolate go together for best effects but the dosing is completely different for everyone. I know my doc likes injectables for people with MCS who can't tolerate B12 any other way but uses a variety of types for others. I don't know all that goes into her decision making but it sure is individualized.