• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To become a member, simply click the Register button at the top right.

Genetic and Genomics Studies in ME

Pyrrhus

Senior Member
Messages
4,172
Location
U.S., Earth
Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study (Perez et al., 2019)
https://forums.phoenixrising.me/thr...-me-cfs-a-pilot-study-perez-et-al-2019.76400/
A genomics pilot study from the team of Nancy Klimas and Lubov Nathanson, using 23andME data provided by patients.


Re-analysis of Genetic Risks for Chronic Fatigue Syndrome From 23andMe Data Finds Few Remain (Bedford and Tzvoras, 2021)
https://www.frontiersin.org/articles/10.3389/fped.2021.590040/full
A critical re-analysis of the above (Perez et al., 2019) pilot study finds problems.



Genetic risk factors of ME/CFS: a critical review (Dibble et al., 2020)
https://academic.oup.com/hmg/article/29/R1/R117/5879704
"Here we critically review existing evidence that genetic factors alter ME/CFS risk before concluding that most ME/CFS candidate gene associations are not replicated by the larger CFS cohort within the UK Biobank."



UK Biobank Genetic Study - Commentary from Decode ME (2021)
https://forums.phoenixrising.me/threads/uk-biobank-genetic-study-commentary-from-decode-me.85204/
An ambitious Genome-Wide Association Study (GWAS) called DecodeME, led by Dr. Chris Ponting, will seek to look at a very large number of patients to answer unresolved questions regarding possible genetic contributions to ME. Whereas DecodeME will focus on looking for common genetic variants, a separate study by the UK Biobank looked for uncommon genetic variants in self-reported CFS patients. DecodeME issues a commentary on the UK Biobank study. The UK Biobank study can be found here: https://www.nature.com/articles/s41586-021-03855-y
 
Last edited:

Pyrrhus

Senior Member
Messages
4,172
Location
U.S., Earth
Last edited:

Pyrrhus

Senior Member
Messages
4,172
Location
U.S., Earth
Genetic association study in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) identifies several potential risk loci (Hajdarevic et al., 2022)
https://forums.phoenixrising.me/thr...al-potential-ris-hajdarevic-et-al-2022.87325/

In this study, we have analyzed three ME/CFS cohorts: a Norwegian discovery cohort (N=427), a Danish replication cohort (N=460) and a replication dataset from the UK biobank (N=2105). To the best of our knowledge, this is the first ME/CFS genome-wide association study of this magnitude incorporating 2532 patients for the genome-wide analyses and 460 patients for a targeted analysis. Even so, we did not find any ME/CFS risk loci displaying genome-wide significance.
 
Messages
11
The Major one I have is GS224 I havent gone through much of the rest of the genome as Im focusing on things I can treat first.

https://pubmed.ncbi.nlm.nih.gov/12003346/

its interesting that they mention red hair. I once tried to lighten my hair and it went bright red ( ginger) and I keep finding the odd red hair scattered in my beard and eyebrows. Ive found three upto now ( natural ) I have dark brown almost black hair.