KdPT Attenuates DSS-Induced Colitis
In the first set of experiments,
the effect of i.p.-administered KdPT was investigated.
For evaluation of the prophylactic potency,
mice received 10 μg of KdPT i.p. beginning 2 days before DSS application for 13 days until the end of the experiment, and control animals received PBS
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157275/
for mg/kg it would be divdied by 12 to get mg/kg for humans
At the beginning of the experiment,
the mean ± SE body weight of all the animals was 20.4 ± 0.53 g
So lets say the animals were 35grams.
That would be 10mcg per 35grams. that would be 280mcg per kg correct?
So human dosage 23mcg/kg for injection ->
1.6mg per 70kg bodyweight as injection.
Animals treated with 5, 10, or 25 μg of KdPT i.p. daily showed a significantly reduced loss of body weight and
recovered significantly earlier from colitis than did controls.
Treatment with 0.5 μg of KdPT i.p. daily did not attenuate the course of DSS-induced colitis,
whereas the group treated with 50 μg of KdPT i.p. daily even developed significantly higher loss of body weight than did control animals (data not shown).
The sweet spot seems to be between 10mcg and 25mcg daily in mice. (10-25mcg per 35grams body weight)
They also tested Oral intake in mice and found dosages below 100mcg per 35grams uneffective. Suggesting oral intake needs at least a ten-fold dosage. Same was indicated by the human oral trial.