Jesse2233
Senior Member
- Messages
- 1,942
- Location
- Southern California
Interesting study in "Toxicology and Industrial Health" from 2009. The study is unique in that a comprehensive protocol was used instead of just one intervention. This of course makes it hard to tease out key variables, but does show the potential benefit of a comprehensive approach.
The patients were defined as having mycotoxicosis but many ME / CFS / CIRS / Lyme / POTS patients have an underlying mycotoxin exposure as a driving cause of their symptoms. The patients in this study were greatly incapacitated and would likely qualify for a CFS diagnosis. 27 out of 28 were able to return to work after receiving treatment.
Protocol:
These are now commercially testable via Great Plains MycoTox panel. I myself tested positive for Ochratoxin A and Aflatoxin M1
Note: I've included a poll below to see if anyone here has experienced benefit from a similar protocol. I don't expect many to have tried AIET but there are likely many people who have used some combination of the other treatments. If you respond to the poll, please list your specific protocol and results in a reply.
I've excluded the Shoemaker protocol from this poll as to not add any more confounding variables, but if you've had success with it please comment as well.
Study abstract and link:
More details on the protocol:
And information on their recovery:
The patients were defined as having mycotoxicosis but many ME / CFS / CIRS / Lyme / POTS patients have an underlying mycotoxin exposure as a driving cause of their symptoms. The patients in this study were greatly incapacitated and would likely qualify for a CFS diagnosis. 27 out of 28 were able to return to work after receiving treatment.
Protocol:
- 2 hrs daily supplemental oxygen
- 30 minute sauna, gentle exercise, deep massage
- Anti-fungals (Diflucan / Nystatin)
- Various vitamin / mineral supplementation
- Organic rotational diet / pure water
- Immunotherapy resembling AIET
These are now commercially testable via Great Plains MycoTox panel. I myself tested positive for Ochratoxin A and Aflatoxin M1
Note: I've included a poll below to see if anyone here has experienced benefit from a similar protocol. I don't expect many to have tried AIET but there are likely many people who have used some combination of the other treatments. If you respond to the poll, please list your specific protocol and results in a reply.
I've excluded the Shoemaker protocol from this poll as to not add any more confounding variables, but if you've had success with it please comment as well.
Study abstract and link:
Abstract Twenty-eight incapacitated individuals (average 43 years old, 7 males, 21 females, range 12-70) exposed to molds and mycotoxins were studied and treated with a protocol of cleaning up or changing their environment to be mold free. Injections of the optimum dose of antigens were given as part of the treatment protocol as was oral and intravenous (i.v.) antioxidants; heat depuration (sauna); physical therapy with massage and exercise under environmentally controlled conditions; oxygen therapy at 4-8 L/min for 2 hours with a special woodgrade cellophane reservoir and a glass oxygen container. Many patients were sensitive to plastics; therefore, exposures to these were kept to a minimum. Autogenous lymphocytic factor was given as an immune modulator. Of 28 patients, 27 did well and returned to work. One patient improved but did not return to work during the period of study
http://cyber.sci-hub.hk/MTAuMTE3Ny8wNzQ4MjMzNzA5MzQ4Mjgx/rea2009.pdf
More details on the protocol:
Total body load (Rea, 1997a,b,c) was reduced by having the patients drink less polluted glass bottled spring water and eat organic food with a rotary diet so that the patient would not eat the same food more than once in 4 days. The patients would avoid any food to which they were sensitive.
The patients had to move out of the contaminated building where they lived or worked until it was deemed acceptable to them. The intradermal provocation-neutralization technique (Lee et al., 1969; Rinkel, 1949) was used to test and treat the offending molds and mycotoxins (aflatoxins, ochratoxins, and tricothecenes).
After an appropriate starting dose was found, treatment injections were given subcutaneously every 4 days. Nutritional supplementation (Rea, 1997a,b,c) was given orally consisting of vitamin C, 6000 mgm daily; B1,2,3,5,6 100 mgm daily; B12 1000 mcg two times per week, and folic acid 1 mgm two times per week. Vitamin D3 400-1200 units per day, natural vitamin E 400- 1200 IU daily and vitamin A 5000 units daily.
Minerals were given daily, including calcium citrate 1000 mgm; magnesium citrate and aspartrate 500 mgm; zinc picolinate or orotate 300 mgm; potassium citrate and aspartate 99 mgm; magnesium gluconate 10 mgm; copper gluconate 2 mgm; selenium methionine 200 mg; chromium 200 mgm; and molybdenum 200 mgm. Essential and semi-essential amino acids (600- 2000 mgm) were given daily including L-tryptophan, lysine, leucine, isoleucine, cysteine, valine, threonine, methionine, arginine, and glutathione. Lipids as a source of omega 3 and 6 EPA plus DHA were also given daily. Either three capsules or three teaspoonfuls were used. Salmon oil, cod oil, flax oil, primrose, borages, or black current oil was administered.
Heat depuration was preferred in environmentally controlled saunas either conventional or infrared, whichever the patient could tolerate. Sweating of 20-30 min was allowed; and 20-30 min on an exercycle was followed by 20 min of deep massage – all performed under environmentally controlled conditions (Rea, 1997a,b,c).
All patients had an immune modulator (0.10 of the 1/ 10 dilution of concentrate) made of 30 culture generations of T-lymphocytes and processed according to the method of Griffiths. Each patient had this autogenous lymphocytic factor given every 4 days.
All patients received one course of an anti-fungal drug of either Diflucan 1 tablet (100 mg.) per day for 2 weeks or Nystatin 250,000 units every day for 1 month.
All patients had oxygen therapy using a glass water reservoir, milk-grade tygon tubing, and a woodderived cellophane reservoir 2 hours per day at 6-8 L (von Ardenne, 1990). For 18 days Wood-derived cellophane was used because patients could not tolerate synthetic petrochemicals in other plastics.
And information on their recovery:
All 28 patients (7 males, 21 females, ages 12-70 years, average age 43 years) completed the study. Ninetyfive percent of the patients improved with treatment being able to return to normal function. In all, 24% patients had elevated tricothecene mycotoxins; 80% returned to non-detectable at the end of the study; 6 had elevated aflatoxin and 100% became nondetectable; and 2 had increased ochratoxins and both returned to normal
Last edited: