Gondwanaland
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I recently experienced salicylate sensitivities and recovered my ability to detox phenols by supplementing magnesium oxide and Saccharomyces boulardii.
These were the pieces of my puzzle:
This reference is also useful because at the same time I experienced intermittent goiter:
You can read all about magnesium here, here and here. Especially here, including warnings and toxicity.
Free download booklet: the 2nd chapter includes a list of magnesium depleting drugs and the last chapter mentions allergies related to magnesium deficiency.
Mercola recently stated that Clostridia helps prevent sensitization to food allergens. In this case beware of overdoing S. boulardii, which is recommended to fight Clostridia strains.
Since I don't know my SNPs, I am navigating through symptoms.
I hope this info can help someone.
izzy
These were the pieces of my puzzle:
- urea and uric acid above range in blood
- urine pH low (4.5 - 5.0)
- magnesium in urine very low below range
THE LANCET, MARCH 20, 1982, P. 691
WHAT DOES PHENOLSULPHOTRANSFERASE DO?
SIR,- Your interesting editorial on phenolsulphotransferase
(Feb. 27, p. 490) states that this enzyme has no clear physiological
function. In view of the widespread distribution of this enzyme in
gut mucosa, liver, platelets and brain,(1) it is surely reasonable to
conclude that its function is to render phenols non-toxic.
Indeed Miller at al.(2) demonstrated this in the cat, an animal that is highly
susceptible to phenol poisoning because it lacks a glucuronidation
mechanism. There may be some humans who are sensitive to phenol
poisoning.(3)
Phenols occur in tea, coffee, and various foods and are
produced by gut bacteria, and the body has to inactivate 300 mg
phenols every day. Their potential toxicity is great. The quinols can
cause uncoupling of oxidative phosphorylation. Phenols are known
to cause convulsions and coma.(4)
It is likely that the enzyme is especially important in patients with acute
hepatic damage and in uraemia. Free phenols can appear in hepatic
coma and they inhibit a variety of enzymes and mechanisms, such as
sodium-potassium ATPase, (5) aminolaevulinic acid dehydratase, malic
and a-ketoglutarate dehydrogenase and the uptake of phosphate by
cells. Their ability to chelate magnesium ions and to interfere with
Mg-ATP and phosphate transfer may be especially important for
neurones.
A rather more restricted set of phenols appear to make
some contribution to uraemic toxicity.(6)
It may be disappointing that no specific role in cerebral function has yet
been identified, but the enzyme nevertheless has general biological importance.
E. N. WARDLE
33 Hawthorn Gardens,
Kenton, Newcastle upon Tyne NE3 3DE
(1) Anderson RJ, Weinshilboum RM Phenolsulphotransferase in human tissue. Clin Chim Acta 1980; 103: 79-90.
(2) Miller JJ, Powell GM, Olavesen AH, Curtis CG. Metabolism and toxicity of phenols in cats. Biochem Soc Trans 1973; 1: 1163-65.
(3) Caldwell J, Davies S, Smith RL. Individual differences in the conjugation of paracetamol with glucuronic acid and sulphate. Br J Pharmacol 1980, 70: 112P.
(4) Matsumoto J, Kiyano S, Nishi H, Kioki J, Ichohoshi T. The convulsive mechanism of phenol derivatives Med J Osaka Univ 1963; 13: 313-24.
(5) Wardle E. N. Phenols, phenolic acids and ATPases. J Mol Med 1978; 3: 319-27.
(6) Niwa T. A. GC-MS analysis of phenols in uraemic sera. Chn Chim Acta 1981; 110:
51-57.
This reference is also useful because at the same time I experienced intermittent goiter:
You can read all about magnesium here, here and here. Especially here, including warnings and toxicity.
Free download booklet: the 2nd chapter includes a list of magnesium depleting drugs and the last chapter mentions allergies related to magnesium deficiency.
Mercola recently stated that Clostridia helps prevent sensitization to food allergens. In this case beware of overdoing S. boulardii, which is recommended to fight Clostridia strains.
Since I don't know my SNPs, I am navigating through symptoms.
I hope this info can help someone.
izzy