Folic Acid, FIGLU, and Thiamine

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Hi guys,

So I have been doing so much better these last two weeks after integrating benfotiamine in place of thiamine HCL. I had been taking 100 - 150mg of Thiamine HCL for over a year and my recent Nutreval test showed high thiamine deficiency, high biotin deficiency, and high folate deficiency (through very elevated FIGLU, which I believe means folinic acid deficiency, not methylfolate). I also did a comprehensive blood panel through Wellnessfx which showed very high Folic Acid levels (16.1 ng/mL). I am homozygous 677t MTHFR mutation and homozygous SLCA1 mutation (folate carrier) and had been taking methylfolate at the time (1000mcg/day). I have been riding the rollercoaster of experimenting with folate with its countless side effects. I have noticed as of late that if I take the benfotiamine in the morning and then wait to take all the other Bs at lunch (methylfolate + folinic acid product, b6 as p5p, active riboflavin, and then adeno hydro b-12), I do not get the brain fog. I have studied the other thread about thiamine and methylation, but could this be a fix? Dr. Lonsdale who spent his career on thiamine brought up a connection about unbalanced thiamine levels and high folic acid in the blood. Not very much info on b1 as a cofactor for folate.

https://epidemicanswers.org/the-folic-acid-paradox-and-the-importance-of-vitamin-balancing/

"The chemist explained that vitamin B-1 is a co-factor in utilizing folate. Perhaps, if B1 were deficient, the underutilized folic acid would back up in the blood. Dr. Lonsdale confirmed the theory by prescribing a large dose of B1, along with a B-complex.Not only were the youngster’s folic acid levels normal upon retesting, but also his lymphatic condition significantly improved."

Thoughts?

Thanks!